My Longevity Experiment

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Global health regulators have been and are currently looking into whether widely used diabetes drugs may contain unsafe levels of a carcinogen NDMA, which has previously been found in heart and gastric medications. This is true; I know the UAE recently stopped selling Zantac (a heartburn medication) in all their pharmacies.

The FDA said in a statement that the agency is testing samples of Metformin sold in the U.S. for NDMA, and that it will recommend recalls of the medication as appropriate

NDMA is a common contaminant found in water and foods including cured and grilled meats, dairy products and vegetables.

Everyone is exposed to some level of NDMA

The Acceptable Daily Intake (ADI) limit for NDMA in the U.S. is 96 nanograms

NDMA may increase the risk of cancer if people are exposed to it above these levels and over long periods of time

But a person taking a drug that contains NDMA at-or-below the acceptable daily intake limit, every day for 70 years, is not expected to have an increased risk of cancer

Jeremy Kahn, an FDA spokesman said in an e-mail ‘The agency is in the beginning stages of testing Metformin; however, the agency has not confirmed if NDMA in metformin is above the ADI limit of 96 nanograms in the U.S.”

Kahn went on to say diabetes is a serious condition and patients who take metformin shouldn’t stop taking their medication without first talking to their doctors,

The (EMA) European Medicines Agency has also said companies should test for high levels of NDMA in metformin. No dangerous levels have been detected in EU supplies to date, and patients should continue taking their diabetes treatments as prescribed.

Metformin is made globally by numerous generic drug-makers.

NDMA is known to cause cancer in animals and is classified as a possible human carcinogen.

Poland’s health minister, Lukasz Szumowski, said earlier that officials were scrutinizing metformin-containing drugs, but that no products would be pulled from the market as NDMA had been found in only trace amounts.

He also urged patients to continue taking their medications, as the benefit of diabetes treatment outweighed any theoretical cancer risk.

In Singapore health officials have recalled 3 of 46 versions of Metformin marketed there after finding NDMA amounts “above the acceptable level.”

Singapore’s Health Sciences Authority said that the recalled drugs had only been sold locally for a short period of time and the risk to patients who had taken them is low

The FDA go on to explained that ‘These investigations take time. We understand that these issues affect patients’ health and well-being in many ways…the FDA will communicate any information we have scientifically confirmed to ensure the public knows as much as possible as soon as possible.

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Links:

https://www.belmarrahealth.com/is-10000-really-the-magic-number-for-heart-health/#:~:text=Any%20number%20of%20steps%2C%20whether%204%2C000%2C%2010%2C000%2C%20or,risk%20for%20heart%20disease%2C%20heart%20failure%2C%20or%20stroke.

https://www.heart.org/en/news/2021/11/16/is-10000-steps-really-a-magic-number-for-health

https://www.medicinenet.com/script/main/art.asp?articlekey=267125

It's a worthy, healthy goal to take 10,000 steps each day, 10,000 is the go-to number that everyone now uses as “the” standard.

Much like the phrase “breakfast is the most important meal of the day”, neither came from doctors, physical trainers or nutritionists. It was a cereal company, one of many who are now contribute massively to the epidemic of childhood obesity in the world

Japanese Technology

So, where did 10,000 steps come from?

·     Well, in the mid-1960’s, Japanese marketers were trying to sell a pedometer named it manpo-kei, which generally translates to "10,000 step-meter" in English.

·     The Japanese character for "10,000" roughly resembles a person walking.

So more of a marketing gimmick than a medical fact, much like breakfast cereals.

Assistant Professor Amanda Paluch, from the School of Public Health and Health Sciences at the University of Massachusetts said "It's a nice clean number and it makes a good marketing message. You can see why it stuck. But there was not a lot of science behind it."

No magic Number

Professor Amanda Paluch is the lead researcher of a new meta-analysis looking at the link between how many steps people take per day and cardiovascular disease. It reinforces the premise that while there's no ONE magic number when it comes to steps, in that any random number could technically be healthier than the one below it.

 The Analysis

Amanda Paluch’s team analyzed seven previous studies whose participants wore step counters and tracked their cardiovascular health.

The research encompassed 16,906 adults whose incidence of heart disease, heart failure or stroke was monitored for a median period of just over six years.

Professor Paluch explained that "We brought all these studies together for a large diverse sample, what we're seeing is that the more steps you do, the more benefit you get."

Segregation

Professor Paluch's team divided the participants into four groups based on their median number of daily steps: 1,951; 3,823; 5,685; and 9,487.

The risk of cardiovascular disease fell as the number of steps increased. The most active group had less than half the number of cardiovascular disease events than the least active, 243 events versus 491 cardiovascular disease events.

Possessor Paluch said "The message is to move more, don't get caught up in 10,000 or any other number. It is not an all or nothing situation for cardiovascular health benefits. Just getting incremental increases in your steps could be meaningful in your cardiovascular health."

Dr. Felipe Lobelo, Heads of the Emory University's Exercise is Medicine Global Research and Collaboration Center in Atlanta, said:

"We knew that more walking is associated with better health outcomes, but this specific outcome – incidence of cardiovascular disease – makes it stronger."

Dr. Lobelo, mention that the meta-analysis was also significant because it used step counters to measure activity accurately, he said:

"In previous studies, most of the evidence we have is from self-reporting exercise; we all tend to overestimate what we do."

The Next Step

The next step regarding steps, Paluch said, is to look at how much “the intensity” of exercise matters and the health benefits beyond cardiovascular considerations, she said: "We want to look at other outcomes, like mental health and cancers. There are many ways physical activity works on the body, and that makes it a great tool for promoting our health and staying healthier for longer."

US Federal Guidelines

At present the US Federal physical activity guidelines urge adults to sit less, move more, and to accumulate at least 150 minutes of moderate-intensity aerobic activity each week; just under 22 minutes a day.

Dr Lobelo, broke down the US requirement by saying "This research shows that the number of steps we should be striving for to generate benefits for cardiovascular disease is lower than 10,000, maybe between 5,000 and 6,000 steps per day, which is pretty much the equivalent of 150 minutes per week."

 10,000 too much!

Processor Paluch said, for many people the figure of 10,000 can be intimidating, no matter how appropriate it may be for a marketing campaign. "If you're not there, don't become overwhelmed and throw in the towel. Think about progressive improvements and working them into your lifestyle and your schedule. Park farther from the store. Take the stairs instead of the elevator. The great thing about steps is we can fit them into our daily lives."

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https://www.qmul.ac.uk/media/news/2021/smd/could-your-smart-watch-alert-you-to-risk-of-sudden-death.html

https://cacm.acm.org/news/253247-could-your-smart-watch-alert-you-to-risk-of-sudden-death/fulltext

https://medicalxpress.com/news/2021-06-smart-sudden-death.html?utm_source=nwletter&utm_medium=email&utm_campaign=daily-nwletter

https://www.soundhealthandlastingwealth.com/health-news/could-your-smart-watch-alert-you-to-risk-of-sudden-death/

This is a review of a study I read that was penned by the Queen Mary University of London, where they explain that researchers have developed an algorithm that could ultimately enable smart watches to alert wearers to potentially deadly changes in their heart rhythm. 

Sudden death

·     A research team from the Queen Mary University of London and the University College London presented their findings to the British Cardiovascular Society conference

·     They described how wearers of smart watches could be alerted to potentially deadly changes in their heart rhythm and could help to identify people at risk of sudden death

 Sudden cardiac death

·     Sudden cardiac death or SCD is a sudden, unexpected death caused by loss of heart function (sudden cardiac arrest). Sudden cardiac death is the largest cause of natural death in the United States, causing about 325,000 adult deaths every year. That’s nearly 1,000 deaths a day

·     Sudden cardiac death is a condition where the heart develops a chaotic rhythm that impairs its ability to pump blood correctly around the body. Sudden cardiac death is responsible for half of all heart disease deaths in the United States

·     Usually, identifying people at risk of Sudden cardiac death requires a hospital visits and specific tests. This new algorithm could, in future, enable everyday wearable technology to detect potentially deadly changes in the wearer's heart rhythm, long before the need for a hospital visit.

SCD not a heart attack

·     Sudden cardiac death is not a heart attack, they are very different, one is an electrical issue, and one is a blockage.

Ventricular arrhythmias

·     The team used data from nearly 24,000 participants from the UK Biobank Imaging study, which was part-funded by the British Heart Foundation, to get a reference for normal T waves on an Electrocardiography or ECG.

·     The T wave represents the time it takes the ventricles (the two larger chambers of the heart) to relax once they have pumped blood out of the heart.

·     An abnormal T wave can indicate an increased risk of ventricular arrhythmia, an abnormal heartbeat that begins in the ventricles, the main pumping chambers of the heart. Ventricular arrhythmias are a major cause of sudden death.

Data analysis

·     The research team then applied their algorithm to ECG data to over 50,000 other people in the UK Biobank study.

They did this to look for an association between changes in the shape of the T wave on a resting ECG, and the risk of being hospitalized or dying because of arrhythmia, heart attack or heart failure.

·     They found that, over time, people with the largest changes in their T waves were significantly more likely to be hospitalized or die due to ventricular arrhythmias.

Dr. Julia Ramirez, lecturer at Queen Mary University of London and the researcher who led the study said "Previously, finding warning signs that someone was at risk of arrhythmias and sudden death would have required them to have an ECG while undergoing an exercise test. We've been able to develop this algorithm so it can analyze ECGs from people taken while they're resting.

This will make it much easier to roll this out for everyday use in the general population.”

 Professor Metin Avkiran, associate medical director at the British Heart Foundation said "Identifying people who are at risk of sudden cardiac death is a major challenge. This algorithm could act as a warning sign that someone is at risk of a life-threatening disturbance in their heart rhythm.

"While more work is needed to test the algorithm, this research is a step forward in our ability to identify people who could be at risk of severe arrhythmias and sudden death and take preventive action."

 Dr. Ramirez closed by saying "Our algorithm was also better at predicting risk of arrhythmia than standard ECG risk markers. We still need to test it in more people, including different cohorts, to ensure it works as it is supposed to.

However, once we've done this, we'll be ready to start studying the integration of the algorithm into wearable technology."

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We all know why David Sinclair would drink a RED wine; Resveratrol, but why the whisky…and these comments also got me to thinking, so here are some of the health benefits that may be gained by drinking whisky, and which may go some way to explaining the reason that David Sinclair chooses whisky, over say brandy, vodka or gin .

https://pubmed.ncbi.nlm.nih.gov/9805220/

https://pubmed.ncbi.nlm.nih.gov/24022993/

https://honey-guide.com/2015/03/17/whisky-polyphenols-and-their-potential-health-effects/

https://www.eurekalert.org/news-releases/703432

https://pubmed.ncbi.nlm.nih.gov/31855413/

https://pubmed.ncbi.nlm.nih.gov/23055633/

https://pubmed.ncbi.nlm.nih.gov/26338173/

https://pubmed.ncbi.nlm.nih.gov/24022993/

https://pubmed.ncbi.nlm.nih.gov/12636463/

https://www.dietaryguidelines.gov/

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1530-0277.2010.01286.x?deniedAccessCustomisedMessage=&userIsAuthenticated=false

https://www.sciencedirect.com/science/article/abs/pii/S0939475310001067

https://www.independent.co.uk/life-style/health-and-families/alcohol-small-amounts-live-over-90-study-health-university-california-wine-beer-a8217521.html

https://www.msn.com/en-us/health/medical/one-major-side-effect-of-drinking-whiskey-say-experts/ar-BB1flTBe

https://www.telegraph.co.uk/news/uknews/1489648/Whisky-helps-fight-cancer.html

http://news.bbc.co.uk/2/hi/health/234957.stm

https://www.hsph.harvard.edu/nutritionsource/healthy-drinks/drinks-to-consume-in-moderation/alcohol-full-story/

https://academic.oup.com/eurheartj/article/36/15/939/2293194#abstract-1

http://whiskyscience.blogspot.com/2016/12/sugars-in-whisky.html

https://www.medicaldaily.com/healthy-diet-alcohol-5-best-low-carb-drinks-prevent-weight-gain-398399

https://link.springer.com/article/10.1007/s13213-017-1311-1

https://www.acsh.org/news/2017/12/01/bacteria-can-live-ice-cubes-not-whisky-12196

Whiskey is an alcoholic beverage that is obtained through grain distillation. The alcohol content of whisky is between 40% and 57%; this qualifies it as hard liquor.

For whiskey to yield any health benefits, it should be consumed in moderation and with all the necessary precautions.

There are links in the description below to studies and articles I used to put this presentation together.

 What is moderation?

·     Whiskey, indeed, any alcohol should only be consumed in moderation for it to yield any health benefits.

In simple terms, moderate drinking refers to a balanced level of alcoholic intake, so the advantages outweigh the risks.

·     According to the US Department of Agriculture and the 2015/2020 Dietary Guidelines for Americans, men should not consume more than 1 or 2 drinks a day, whereas women should only take one drink a day.

·     Because whisky is classed as hard liquor, and should therefore be consumed more prudently, the daily measure is 1.5 ounces (44.3 Milliliters); a normal shot of whisky is between 1.25 and 2 ounces.

 Nutrient Content of Whiskey

·     According to the US Department of Agriculture, 100 grams of distilled whiskey contains the following:

·     63.9 grams of Water

·     350 kcal’s, 1 kilo-calorie is equal to 1000 calories

·     0.1 grams of carbohydrates

·     0.02 milligrams of Iron

·     1 milligram of Potassium

·     And 36 grams of Alcohol

 Health benefits

·     The potential health benefits of taking a dram should not compel non-drinkers to start drinking or responsible drinkers to overindulge

·     The principle of moderation in everything especially applies to alcohol, as excessive intake can severely harm your body and your social well-being. I think David Sinclair’s one whisky a night would fall into the category of moderation.

That said, let’s look at the possible benefits that may be gained from a measured intake of whiskey.

Cognitive disorders

·     Drinking whisky may help protect against some cognitive disorders, indeed all types of alcoholic beverages, including whiskey, have been shown to exhibit antioxidant properties.

·     The antioxidant phytochemicals in whiskey positively influence GABA receptors to maintain a healthy chemical balance in the brain.

·     This can help protect against the debilitating ramifications of depression, Alzheimer’s disease, dementia and schizophrenia, but more research is needed to fully establish these claims

 Heart disease

Drinking whisky may also decrease the risk of heart disease.

·     Those who engage in light to moderate drinking (I think David Sinclair’s one whisky a night would fall into this category) tend to have a lower risk of congestive heart failure, stroke, diabetes, coronary artery disease and total mortality.

·     Conversely, people who consume excessive amounts of alcohol are more prone to cardiovascular problems, this is common sense, and is more than likely the reason that David Sinclair specifically said he has ‘a’ whiskey, as in one

 Control urate levels

Drinking whisky may also help control urate levels

·     High uric acid levels are responsible for painful conditions such as gout, this is where the excess uric acid crystallizes and accumulates in the joints.

·     Some clinical studies suggest that light to moderate whiskey consumption can promote the excretion of urate through the urine,

Again, I think David Sinclair’s one whisky a night would fall into the category of light to moderate whiskey consumption.

 Blood sugar levels

·     So, as well as having positive effects on the body, whisky may also be the healthiest alcohol you can drink. It contains no fat and hardly any sugar or carbohydrates. It barely alters the level of sugar in your blood, making it a better choice for diabetics than other alcoholic beverages.

·     A single whisky contains around 90 calories, compared to a standard glass of red wine which contains around 150 calories.

 Stomach enzymes

·     The enzymes found in whisky even help to stimulate the stomach enzymes, which help to break down our food.

Amazingly, whisky can even kill infection-causing bacteria which no other spirit does.

·     The medical journal ‘Springer’ published a study which showed that whisky kills common bacteria found in ice cubes, such as staphylococcus, responsible for some forms of skin infections and food poisoning, and pseudomonas, which can cause skin and lung infections.

Unfortunately, we don’t know if David Sinclair takes his neat or on the rocks.

 Urban Myth

·     Let’s quickly talk about the Hot Toddy, does the whisky help? 

A hot toddy is an anecdotal concoction that is mostly used for relieving the symptoms of the common cold and flu.

·     Typically, a hot toddy is prepared by mixing lemon, honey, and hot water with whiskey, but you can also use green or black tea instead of alcohol.

The immune-boosting properties of this tonic are mostly attributed to the nutrients found in the lemon and honey, rather than whiskey.

The dark side

·     Unchecked alcohol consumption or alcohol abuse not only hampers your overall physical and mental health, but also poses an immediate risk to your safety; as well as the safety of others around you by dulling your senses and effecting your reaction time.

 Long Term Health

·     Many long-term health problems such as

high blood pressure (called hypertension),

inflammation of the liver (called alcoholic hepatitis),

scarring of the liver tissue (called cirrhosis of the liver)

and cardiomyopathy are attributed to long term alcohol abuse.

Long Term Health

·     Alcohol can induce a temporary analgesic effect by blocking certain pain signals to the brain, but excessive dependence on alcohol for managing pain can do more harm than good - and can lead to more serious complications in the long term.

So, I think the main thing to reiterate here is moderation, and for those who cannot drink responsibly, and abstain as a consequence, should not start because of the potential benefits

So, those who don’t drink should not start, and those that do should aim for moderation, for men 2 drinks maximum a day and for women 1 drink a day

And that doesn’t mean, nothing for 6 days and then 7 or 14 on the 7th day

So, those are some of the medical reasons that David Sinclair may drink a whisky, or it may just be something that he likes to do with family and friends at the end of the day. 

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So, following my Renue by Science Subscription Service Video, I received this comment form AK asking if I could do an updated David Sinclair Longevity Stack video using the new 15% off prices, AK asked, so here it is… 

So, in this video I will only look at the supplements in David Sinclair’s Stack that can be bought from Renue by Science, so I won’t include aspirin or yogurt as I normally do.

·     As before, I will only cover what he says David Sinclair actually states in his book, or has specifically mentioned on his podcast or when being interviewed on YouTube one-on-one

There are a number of other Health type Blogs etc. that say or assume he takes other things, but I shall not include those.

As we know NMN is used to raise our NAD levels:

·     100 grams of NMN powder from Renue by Science will cost you $114.95

·     Add to that the 15% MYNMNSUB discount and that drops to $97.71

·     That in turn works out at $0.97 a gram

·     Cost per month      = $29.10

·     Cost per year        = $349.20

 Resveratrol

And according to David Sinclair it is accelerator pedal for NMN, it promotes hormesis, and it also activates the sirtuins

He mixes resveratrol powder into his yogurt at breakfast, you can buy it in capsules, but then you would need to break them open to mix with a fatty food, so I have only looked at powder options

·     100 grams of resveratrol powder from Renue by Science will cost you $84.95

·     Add to that the 15% MYNMNSUB discount and that drops to $72.21

·     That in turn works out at $0.72 a gram

·     Cost per month      = $21.60

·     Cost per year         = $259.20

Metformin

As you know David Sinclair uses Metformin, he has mentioned 800mg & 1g as his dose, taken at night, but in many countries, Metformin is a prescription drug, those that can’t get it tend to use Berberine instead, so that is what I have costed

·     90 x 150mg capsules of Liposomal Berberine from Renue by Science will cost you $49.95

·     Add to that the 15% MYNMNSUB discount and that drops to $42.46

·     That in turn works out at $0.47 per capsule

·     Cost per month      = $14.10

·     Cost per year         = $169.20

Vitamins D3/K2

David Sinclair says he takes Vitamin D.

Vitamin D regulates calcium and maintenance of phosphorus levels in the blood. These factors are vital for maintaining healthy bones.

Vitamin D also allows the intestines to stimulate and absorb calcium, and reclaim the calcium that the kidneys would otherwise

·     60 x 2 milliliter doses (that’s 2,500 IU) of Vitamin D3 from Renue by Science will cost you $22.95, it also includes 250 micrograms of Vitamin K2

·     Add to that the 15% MYNMNSUB discount and that drops to $19.51

·     That in turn works out at $0.32 per day

·     Cost per month      = $9.60

·     Cost per year         = $115.20

But why include Vitamin K2?

K2 ensures that the calcium goes to our bones and teeth and not our soft tissue like our kidneys.

TMG

·     After much debate and rumor mongering in an interview with Dr. Mercola David Sinclair did indeed reveal he was taking TMG, he didn’t mention a dose so I shall assume he takes it 1:1 with NMN as that is the maximum ratio I have seen mentioned in various places.

·     90 x 500mg capsules of TMG from Renue by Science will cost you $13.95

·     Add to that the 15% MYNMNSUB discount and that drops to $11.86

·     That in turn works out at $0.26 per gram

·     Cost per month      = $7.80

·     Cost per year         = $93.60

 Quercetin

Quercetin has been shown in some trails to be beneficial at killing off senescent cells

·     David Sinclair on his Podcast explained that he takes his Quercetin every day at breakfast mixed into his yogurt, this is what he calls a maintenance dose as opposed to a ‘big bang’ larger dose once a week, or once a month for a few days

·     90 x 150mg capsules of Liposomal Quercetin from Renue by Science will cost you $47.95

·     Add to that the 15% MYNMNSUB discount and that drops to $40.76

·     That in turn works out at $0.45 per day

·     Cost per month      = $13.50

·     Cost per year         = $162.00

 Fisetin

 Fisetin has been shown in some trails to be beneficial at killing off senescent cells

·     David Sinclair on his Podcast explained that he takes his Fisetin every day at breakfast mixed into his yogurt, this is what he calls a maintenance dose as opposed to a ‘big bang’ larger dose once a week, or once a month for a few days

·     90 x 150mg capsules of Liposomal Fisetin from Renue by Science will cost you $64.95

·     Add to that the 15% MYNMNSUB discount and that drops to $55.21

·     That in turn works out at $0.61 per day

·     Cost per month      = $18.30

·     Cost per year         = $219.60

 Spermidine

Spermidine is a polyamine known for activating autophagy.

·     Studies have shown that spermidine may delay ageing in humans, support the reduction of age-related diseases, upregulate sirtuin 1 and provide anti-inflammatory benefits

·     David Sinclair on his Podcast explained that he takes 1 gram of Spermidine a day, but he is only experimenting with this and will wait to see the results, so I shall not include this as a permanent addition just yet.

Total Costs:

The cost of the whole stack of NMN, resveratrol, Berberine, fisetin, quercetin, Vitamin D3/K2 and TMG is:

·     These prices already include the 15% MYNMNSUB discount

·     Monthly: $114.00

·     Yearly: $1,368.00

 Total Daily Costs:

Those numbers may look high to some people, so, what will David Sinclair’s longevity stack cost you per day?

Well, the whole stack will cost:

·     $3.80 a day, again the 15% MYNMNSUB code already applied

·     He says he is just experimenting with Quercetin and Fisetin, so not set in stone just yet, his stack without those then becomes $2.74 per day

·     To put that in context, for me, at my favourite coffee shop when I have an organic Americano it costs me AED 17 that’s around $4.60

So, for me that that's David Sinclair’s “Stack” including Quercetin & Fisetin from Renue by Science, using their subscription service and the 15% MYNMNSUB code at checkout, for less than the cost of 1 cup of coffee a day.

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DON’T TAKE NMN UNTIL YOU HAVE READ THIS

1.   Hi and welcome back, if you are new to the podcast my name is Vince, thanks for tuning in, you are very welcome here indeed. 

 Let’s discuss things to consider before taking NMN as an anti-aging supplement

 Before I started to take NMN as a daily supplement I did a great deal of research and there were some important questions and concerns that kept coming up.

Things I had ponder and ultimately make a decision on, one way or the other as to whether I would or would not start to take NMN to boost my NAD levels.

 In this podcast I will share with you those keys areas and if you are considering taking NMN I hope that they help.

 2.   Let’s talk about the lack of Clinical trials

To date, only clinical trials with mice have produced substantiated results on the efficacy of Nicotinamide Mononucleotide (NMN). Should we trust the results from mice, if so why?

ü 95% of all Lab animals are mice and rats, this is according to the Foundation for Biomedical Research (FBR).

ü They are used mainly because they have a short lifespan - two to three years, so several generations of mice can be observed in a relatively short period of time

ü Mice used in medical trials are inbred so that, other than gender, they are almost genetically identical

ü Their genetic and biological characteristics closely resemble those of humans, and many symptoms of human conditions can be replicated in mice

At the time of this podcast, only data from one human clinical trial into the safety of NMN has been published, I review the safety report in podcast #7 and on my YouTube channel.

Human trails with regard to efficacy are still on-going; so no results have yet been published. 

So, do you want to take a supplement that, at present, has only been successful during animal trials, or will you wait for the human trails to conclude?

3.   So, what’s the recommended daily dose for NMN?

Although NMN is commercially available, there is no official Recommended Daily Allowance, however there are numerous protocols on the back of NMN packaging stating how much to take and how many times to take it during the day, bear in mind that at present all of these companies are guessing!

 No official protocols have yet been established i.e. before food, with food, after food, on an empty stomach, in the morning, just before bed etc. So, we are still at the ‘suck it and see’ stage, as David Sinclair has said, with regard to humans and NMN we are all guessing.

 David Sinclair has explained that he takes one gram of NMN a day in the morning with his coffee. In a show with Joe Rogan, Rhonda Patrick shared a formula from an NMN clinical trial (unfortunately she didn’t discuss which trial) of 24 mg of NMN per kilo of body weight.

 If David Sinclair follows this formula it would make him 42 kilos, anecdotal comments on my YouTube channel put him at around 62 kilos, using Rhonda Patrick’s formula he should be on approximately 1.5 grams a day, why the disparity?

4.   Cost is definitely a metric to consider

The cost of NMN varies vastly depending on the type (powder or capsules) and the seller. In the time I have been taking NMN prices have come down significantly, but it is still relatively expensive, the average cost of NMN powder is between $2 and $5 a gram. If you consider buying your NMN from DoNotAge.org, at the checkout use the code ‘MYNMN’ for a 10% discount on all your purchases.

5.   You may want to consider independent third party testing of your NMN,

Some people prefer to do this, especially if they buy direct from a supplier such as Alibaba. This extra expense could cost you anywhere between $300 to $500 per batch to test for purity and heavy metals. If you are considering buying NMN, please ensure that the company you use does have independent third party test certificates and that they test for heavy metals.

 Most reputable, trustworthy suppliers will provide you with a third party Certificate of Analysis/Assay (COA), if they can’t/won’t provide you with these certificates it may be advisable to seek out another supplier.

6.   What about medical tests and expenses?

As the benefits and side-effects of Nicotinamide Mononucleotide (NMN) have not yet been officially established in humans, you may wish to consider having medical tests completed so you can monitor any markers you think may be important; a biological age test may be one, muscle mass or wastage, body fat percentage, liver and kidney functions etc.

Taking these tests regualry are a good idea anyway, as an aside, I do these tests every 3 months and after 18 months all my markers are looking good.

7.   So, what of NMN purity and grade?

There are no grades of NMN; there is only one compound (it has the CAS Number: 1094-61-7) and that is NMN. 

NMN suppliers who try to set themselves apart from the competition by using tags or labels such as Pure NMN, or Ultra-pure NMN, Elevated NMN or most bioavailable NMN are misleading you somewhat.

NMN is NMN, the only thing you should consider paying more for is the purity level, even then what is the difference in efficacy for humans between 95% purity and 99.5% purity, nobody knows, nobody will know until countless human efficacy trials have been conducted and the results posted. 

Don’t be lured in by false claims and advertising gimmicks!

 8.   How are you going to take your NMN?

You can take it orally or sublingually, two simple definitions are:

ü   Oral administration, is a route of administration where a substance is taken through the mouth and swallowed; this can be in tablet form or mixed with a liquid

ü   Sublingual administration, is where a tablet or powder is placed under the tongue and allowed to dissolve

There are conflicting views on the best form of application, one study recommends sublingual administration, while David Sinclair, and his mice during the clinical study took their NMN orally. 

Some companies have tried to cut out a niche in the market by only selling sublingual products and casting aspersions on all oral applications, again until a significant number of human clinical trials have been conducted and the results published, nobody really knows!  

9.   Will you buy your NMN monthly or in Bulk to save money?

You may wish to consider reducing the cost of your NMN by buying in bulk directly from a seller such as Alibaba, or subscribing to a compay that offers a yearly subscription service such as DoNotAge.org.

The minimum bulk order from Alibaba is usually around 1 kilo, so to prevent wastage as NMN is considered to have a shelf life of two years, you may wish to consider buying as part of a collective.

The joint purchase option also allows for the cost of independent third party testing to be shared.

There are a lot of charlatans out there, so although companies that sell on Alibaba may look like a cheap option, I would recommend buying forma reputable supplier.

 10. So, Nicotinamide Mononucleotide (NMN) is an exciting molecule that promises exceptional results, however at the time of this podcast only one NMN safety trial has been conducted. 

NMN efficacy trails are still ongoing, even when complete the experts say that to be sure, many long-term efficacy trials will need to be completed before any definite advantages of NMN can be officially published.

This time delay may be too long for some people to wait, so many people, myself included, have taken the plunge and have started to supplement with NMN on the basis of one human safety trail.

 Is time on your side, or will you take ‘the bull by the horns’ on the strength of one safety trial, a couple of mouse studies and my NMN Experiment?  

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NMN Human Safety Trial Concludes in Japan

1.   Hi and welcome back, if you are new to the podcast, thanks for tuning in, you are very welcome here indeed.

 So, a non-blinded clinical trial has been conducted at the Clinical Trial Unit, Keio University’s School of Medicine in Japan, the study was on 10 healthy men aged between 40 and 60, the aim was to ensure that there were no adverse side effects to taking NMN.

 2.   A non-blinded trial describes a clinical trial, or other experiment, in which the researchers know what treatments are being given to each study subject, and the subjects involved know what treatments they are receiving.

 This small human trial of NMN achieved what it set out to establish: to demonstrate that the supplement is safe and well tolerated, at the dosage used, on humans.

 The trial did not set out to demonstrate the efficacy of NMN, and given the small number of trial participants, the single dose, and the short study time, it was never going to do more than establish that the drug is safe for human use.

 3.   Some volunteers were excluded from the trail, if they fell into the following categories:

·      Previous history of diseases, but nothing specific described in the report

·      Malignant neoplasms, which means a tumor that is cancerous

·      Serious infections, not specified, but maybe infections such as Influenza, an STD, hepatitis, HIV or MRSA

·      Psychiatric disorders, again not specified, but maybe Bipolar disorder, anxiety disorders, PTSD or Schizophrenia

·      Ophthalmic disorders, again not specified, but maybe Conjunctivitis, Cataracts, Glaucoma

·      Allergic disorders, maybe asthma, food allergies, medication allergies

·      Metabolic diseases

 4.   During the study (for 5 hours after the administration) the researchers observed various biomarkers such as:

·      Heart rate

·      Blood pressure

·      Oxygen saturation

·      Body temperature

Urine was collected every 30 to 60 minutes for the first 2 hours after administration and at the end of the study. Blood was collected every 5 to 20 minutes for the first hour, followed by every 30 to 120 minutes for the next 4 hours.

5.   Ophthalmic examinations (on the left eyes) were conducted (by registered op-thalmologists) on the day of intervention, both before and after the administration, covering visual acuity and functional visual acuity; this includes:

·      The sharpness of the retinal focus within the eye,

·      The health and functioning of the retina

·      The sensitivity of the interpretive faculty of the brain

The quality of sleep was also evaluated, it was evaluated using the Pittsburgh Sleep Quality Index (PSQI) before and after the day of intervention.

6.   The researchers could not detect NMN in the blood samples taken during the study, but this is likely due to them being frozen, which may have degraded the NMN.

So, could freezing NMN also cause some degradation, or was it because the blood plasma acted as catalyst? Interesting, as keeping NMN refrigerated or frozen is now the norm in the NMN community. The report also mentions that NMN degrades rapidly in blood that was handled above 80 degrees centigrade (176 F).

 7.   So, onto the results

Results of ophthalmic examination and sleep quality score showed no differences before and after the intervention.

The only notable result was that bilirubin levels rose by 51.3% and glucose fell by 11.7. However, it was concluded that those two changes were most likely associated with the overnight fast prior to taking NMN and the five-hour fast following administration.

 8.   No significant changes were evident following the single dose of NMN, although this was to be expected, as the dosage range used of 100, 250, and 500 mg was fairly low.

 The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant harmful effects.

 So, oral administration of NMN was found to be feasible. These results are fairly unimpressive, but this is a good thing, it means the study was a success, in that NMN is safe for humans to take, well at least in the short term and in the doses used during the clinical trial.

Notable limitations worthy of mention are that this was not a placebo-controlled study and that NAD+ and plasma NMN levels were not measured in this study

9.   In summary, there have been a lot of animal studies; however, the safety and efficacy of NMN in humans was unclear, this trial helps to confirm that, in general, the compound is safe and well tolerated; to that end, the trial can be considered a success.

The next step for researchers will be to investigate the efficacy of NMN; then hopefully a suitable dosage and frequency protocols can be officially established.

 10. Of course, it is certainly possible that NMN may fail during efficacy testing in humans, but this initial safety study has no bearing on that potential outcome.

There is currently an ongoing human trial for NMN at the Brigham and Women’s Hospital in Boston, from which efficacy data should be forthcoming, until that data is posted, no real conclusions, beyond NMN being safe for human consumption, can really be drawn.

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This podcast ‘four more reasons to take NMN’ is the second podcast on this subject, please feel free to check out the first Podcast, ingeniously titled ‘four reasons to take NMN’

So why do we take NMN?

At the time of recording there are two methods of taking Nicotinamide Mononucleotide (NMN), they are:

·      Orally, by ingesting/swallowing NMN in either capsule form or by mixing it into a liquid or food

·      Sublingually, by placing NMN powder under the tongue and allowing it to diffuse into the bloodstream through the soft tissue

Is there any scientific proof that confirms that one method is better that the other?

Why should we take NMN? The only reason is to raise our NAD Levels, but why should we try to raise our NAD levels?

NAD or Nicotinamide Adenine Dinucleotide to give it its full name is present in nearly all of our living cells, and NAD+ is essential for sustaining life.

Unfortunately, our NAD levels decline radically with age; this creates an energy deficit that decreases our body’s ability to maintain effective biological functions.

As a compound NAD is biologically unstable, this makes it unsuitable for oral supplementation.

Fortunately, it may be easy to restore our cellular NAD levels using NAD boosters such as Nicotinamide Mononucleotide (or NMN); NMN is believed to convert into NAD when it has entered the cell.