Welcome back to the Hot Topics podcast with Neal Tucker.

Finally some hope with an imminent COVID vaccine. But how good is it really and where is the data? Meanwhile general practice has been set up as the saviour of the nation but can we really vaccinate the entire population? The Committee of Horribly Absurd Orders thinks so or is it part of their long-game to say CHAO to GPs? And also some good news that we may not have to store this new vaccine at -70oC after all...

For published research we look at SSRIs for acute COVID in the community, suspect rapid antibody tests and the harm from delayed cancer treatments.

References

NS Vaccine review and report on storage
JAMA SSRI and COVID trial
BMJ Accuracy of Rapid Antibody Tests
BMJ Mortality due to cancer treatment delay

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Hello again! In this podcast Dr Neal Tucker is joined by Dr Philippa Davies, a GP with a special interest in dermatology, to talk about the many and varied skin presentations of COVID-19 and how we might want to carefully scrutinise the rashes we're seeing over the next few months.

To make it as interactive as possible follow along using www.covidskinsigns.com and you'll be able to see exactly what we're talking about!

Also today, comedic one-liners to lighten the mood, rates of Long Covid and who is at risk, QCOVID and the latest from the major journals from the last two weeks.

References

COVID Skin Signs website from the British Association of Dermatologists
Pre-print of Long Covid Rates
Lancet SARS-CoV-2 Antibody Rates in Dialysis Patients
JAMA Editorial on Excess Mortality Rates 2020
BMJ QCOVID Paper 

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Welcome back! In this episode, Dr Neal Tucker talks about the world's biggest news story: President Trump and his treatments. Should we all be getting the same? He also looks at flu vaccinations and appraisals, and challenges the Committee of Pointless S%&t to cut the crap.

In the latest research, we look at newly published data on SGLT2 inhibitor use for heart failure and renal disease in patients without diabetes and the benefits of high intensity training for longevity.

Resources:
J o Hospital Medicine and Dexamethasone study
CEBM Review of REGN-CoV2
BJGP Editorial on Appraisals
NEJM Journal with SGLT2i data
BMJ Paper on Exercise in Older people

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Welcome back to Season 2 of the Hot Topics podcast with Neal Tucker.

In this episode, we discuss THAT letter, whether we can differentiate a Covid cough from a simple URTI, how long SARS-CoV-2 antibodies actually last, plus research on SGLT2 inhibitors, gut instinct and the power of continuity in general practice.

Find us on @gphottopics, Facebook or email [email protected] 

• RCPCH statements on Covid in children
• UK Study Study symptoms in children 
• JAMA Antibody durability study
• Lancet SGLT2i met-analysis
• BJGP Gut Feeling in diagnosing cancer
• BJGP Continuity and mortality
• BJGP Continuity and patient perception of GPs

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In this final podcast for the summer Dr Neal Tucker reflects on the latest news and research in the world of general practice from the past two weeks.

As COVID cases start to rise again we look at the latest research on the transmission of COVID via schools and why we all need a change in mindset about working when ill. We consider the role of GPs in taking away a patient's car keys and giving them a bike. And we look at vaccines with positive news on COVID immunisation and the difficulties of delivering 30 million flu immunisations in the Autumn while donning and doffing PPE.

Back in September, have a good summer everyone!
Neal

Resources:
BMJ paper on physical distancing
JAMA paper on COVID and school transmission

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Welcome to the latest episode of the Hot Topics Podcast with Neal Tucker from NB Medical.

All about coronavirus again! The two big topics this week are immunity and the importance of T cells plus an in-depth look at post-COVID syndrome, how we can anticipate the effects on the population and the resources that can help us manage it.

We've also got research on remdesivir and more on how SARS-CoV-2 affects children, plus why COVID-19 isn't a lifestyle disease but lifestyle medicine still has a role in general practice.

References:
Moving Medicine evidence review
NHS After-care needs of inpatients recovering from COVID-19
Royal Society of Occupational Therapists Fatigue Management Guide
Homerton University Hospitals Post-COVID Patient Pack
NEJM Remdesivir RCT
NEJM Children & COVID 19 Italy Letter
JAMA Persistent Symptoms after Acute COVID

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In our latest Hot Topics podcast, Neal Tucker discusses the latest news and research for primary care.

This week a firm focus on coronavirus once again. We talk about antibody tests and why there seems such discrepancies between the real world results in you and I and the tests' supposed accuracy. We talk about dexamethasone and the implications for primary care. And we discuss the possibility of a 2nd wave of coronavirus, how this will our jobs in primary care and what we can do to keep ourselves happy.

References
St George's Antibody Data
Recovery Trial Dexamethasone Results
Lancet Report in Iran's 2nd wave 

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In the latest episode of the Hot Topics Podcast, Neal Tucker discusses the latest news and research relevant to primary care.

Today we talk about race, inequalities and unconscious bias and how this affects decisions about BAME medics in the UK. We also look at a Lancet paper on hydroxychloroquine risks which has been retracted due to suspicious reporting of data, and the 'tsunami' of mental illness anticipated due to coronavirus.

In new research we discuss government recommendations on face masks for the public in light of a new systematic review published in the Lancet on reducing the spread of SARS-CoV-2, use of the NEWS score in primary care and liraglutide as a weight-loss treatment for childhood obesity.

Don't forget to join us for our free Hot Topics Mental Health and COVID-19 webinar. Sign up at:

https://bit.ly/NBMedicalCOVIDMentalHealth

Links:
BJGP Protecting Health of Doctors https://bjgp.org/content/70/695/268
Lancer Retraction of Hydroxychloroquine Paper https://www.thelancet.com/lancet/article/S0140673620313246
Lancet Prevent of spread of SARS-CoV-2 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31142-9/fulltext
RCPsych Report on mental illness and Covid 19 https://www.rcpsych.ac.uk/news-and-features/latest-news/detail/2020/05/15/psychiatrists-see-alarming-rise-in-patients-needing-urgent-and-emergency-care
MIND Coronavirus resources https://www.mind.org.uk/information-support/coronavirus/
NEJM Liraglutide in adolescents study https://www.nejm.org/doi/full/10.1056/NEJMoa1916038?query=featured_home

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In this latest Hot Topics Podcast, Neal Tucker reviews the latest knowledge about coronavirus and non-SARs-CoV2 research relevant to primary care.

We review new reports of Kawasaki-like disease in children with Covid-19 and the implications for children returning to school. We examine data on hydroxychloroquine and azithromycin suggesting it may kill more than it cures. And we have a think about testing and the new antibody tools.

In non-coronavirus research, we look at SGLT2i and renal disease, P2Y12 inhibitors and CVD secondary prevent, whether GPs are successful in helping patients with weight loss and gestational diabetes.

References
Kawasaki-like Disease in Children with Covid-19 https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31103-X/fulltext
Hydroxychloroquine for Covid-19 https://www.bmj.com/content/369/bmj.m1361
Hydroxychloroquine + azithromycin https://jamanetwork.com/journals/jama/fullarticle/2766117
Lopinavir Ritonavir in Covid-19 https://www.nejm.org/doi/full/10.1056/NEJMoa2001282?query=featured_home
BCG vaccination and Covid rates https://jamanetwork.com/journals/jama/fullarticle/2766182?guestAccessKey=a37db46c-11e4-4243-b878-648c9bf2631a&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=051320
Interpreting Test Results https://www.bmj.com/content/369/bmj.m1808
SGLT2i and renal disease https://www.bmj.com/content/369/bmj.m1186
P2Y12 inhibitors and CVD https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30315-9/fulltext
Gestational Diabetes progression https://www.bmj.com/content/369/bmj.m1361
Paid for weight loss programme referrals from GP https://bjgp.org/content/70/694/e348

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In our latest Hot Topics podcast Neal Tucker examines the emerging treatments for Covid-19 including remdesivir, antiplatelets, vitamin D and vaccinations. Do these provide the magic bullet we need to shut down the infection and open up the world?

He also reviews the latest research including data on asymptomatic and pre-symptomatic disease in children, important for when schools re-open, and the elderly, important for managing Covid-19 in care homes. He also looks at some emerging data on the extra-respiratory effects of the disease and how it may present in primary care.

References:

• Children and covid: www.jamanetwork.com/journals/jamapediatrics/fullarticle/2764394
• Children as vectors: www.thelancet.com/journals/laninf/article/PIIS1473-3099%2820%2930236-X/fulltext
• Risk to children BMJ Editorial: https://www.bmj.com/content/369/bmj.m1669
• Care Home Transmission NEJM: https://www.nejm.org/doi/full/10.1056/NEJMoa2008457?query=featured_home
• JAMA Homeless Shelter: https://jamanetwork.com/journals/jama/fullarticle/2765378
• Remdesivir https://www.bbc.co.uk/news/health-52478783
• Antiplatelets: https://www.sciencedirect.com/science/article/pii/S2211383520305529
• ACEi/ARB benefit: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.120.317134
• New Scientiest 4 Coronaviruses: https://www.newscientist.com/article/mg24632800-700-what-four-coronaviruses-from-history-can-tell-us-about-covid-19/

www.nbmedical.com/podcast