Editor-in-Chief, Robert Amdur, MD, discusses RT before, rather than after, mastectomy in patients with locally advanced breast cancer being treated with neoadjuvant chemotherapy. The discussion is based on a paper published in the July 2023 issue of PRO titled “Pathologic Complete Response and Oncologic Outcomes in Locally Advanced Breast Cancers Treated With Neoadjuvant Radiation Therapy: An Australian Perspective" (2023, Issue 4, July/August, PMID: 36599393).