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Editor-in-Chief, Robert Amdur, MD, discusses radiation and chemotherapy programs to use prior to surgical resection of rectal cancer. The main reference for the podcast is a Topic Discussion paper published in the January 2023 issue of PRO titled "Neoadjuvant therapy in the post-German rectal trial era: making sense in the absence of consensus" (2023, Issue 1, January/February). The discussion explains the concepts driving the evolution of neoadjuvant therapy, recommended radiotherapy and chemotherapy programs, and situations where it is acceptable to observe without surgery.