NeuroFrontiers

Patients with Alzheimer's disease—especially APOE4 carriers—show distinct epigenetic immune alterations that may influence disease progression, treatment response, and side effect risk. In this episode, Dr. David Gate, an Assistant Professor of Behavioral Neurology at Northwestern University, dives into his research on this subject and explains how chromatin accessibility in proinflammatory genes and T-cell receptor changes link to neurological pathology.

Multiple sclerosis (MS) presents with far more than just mobility issues—fatigue, spasticity, bladder and bowel dysfunction, cognitive changes, and mood disorders are frequently underrecognized but deeply impactful. Dr. Marisa McGinley, a neurologist at the Cleveland Clinic, explains how to identify subtle clinical changes, utilize patient-reported outcomes, and engage in proactive symptom discussions that support timely interventions.

Multiple sclerosis (MS) treatment has transformed dramatically, with a wide range of high-efficacy options currently available. Dr. Marisa McGinley, a neurologist at the Cleveland Clinic, explores how advancements in drug availability, administration methods, and efficacy are reshaping care, with a focus on sequencing strategies and the growing movement toward early, aggressive treatment. Learn how to integrate patient preferences, comorbidities, and shared decision-making into personalized therapy plans.

Multiple sclerosis (MS) presents a diverse range of symptoms that require coordinated, expert care. Dr. Marisa McGinley, a neurologist at the Cleveland Clinic, provides practical strategies for neurologists to serve as the central point of contact for patients with MS, initiate targeted treatments, and engage a variety of specialty teams in collaborative management.

EEG-guided headphones from Vital Neuro present a new frontier in anxiety management through personalized, real-time neurofeedback and music therapy. Dr. Michael Greenberg speaks with Vital Neuro CEO John Golden about the science behind these devices, their effectiveness in reducing anxiety symptoms, and how they can integrate into daily life.

Neuro-responsive EEG headphones are helping healthcare professionals combat burnout by promoting calm, focus, and resilience. Backed by neuroscience and real-time brain monitoring, this personalized technology blends music and neurofeedback to optimize mental states and reduce stress. Hear from Vital Neuro CEO John Golden as he joins Dr. Michael Greenberg to discuss this device's impact in clinical workflows, from pre-op anxiety management to enhanced physician well-being.

Many patients with multiple sclerosis (MS) experience neurogenic bladder symptoms—ranging from urgency and incontinence to retention and infection risk—but these issues are often underprioritized in care. Based on recent research, remote, commercially available bladder monitoring tools can help address this unmet need and uncover day-to-day fluctuations in bladder function. To learn more about this research, tune in to hear from Dr. Riley Bove. Not only is Dr. Bove a practicing neurologist and clinician scientist in the UCSF Weill Institute for Neurosciences, but she also presented a session on this exact topic at the 2025 Consortium of Multiple Sclerosis Centers Annual Meeting.

The symptom variability, prolonged asymptomatic periods, and inconsistent presentations of generalized myasthenia gravis (gMG) often lead to significant diagnostic delays and misdiagnoses. Based on recent studies, these delays then correlate with increased disease severity, longer time to symptom control, and worsened quality of life. Here to help uncover the hidden toll of diagnostic delays on patients with gMG is Dr. John Morren. He’s the Program Director of the Neuromuscular Medicine Fellowship at Cleveland Clinic and an Associate Professor of Neurology at Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

From pregnancy planning and postpartum relapse risk to the overlapping symptoms of menopause, women with multiple sclerosis (MS) face unique challenges throughout the reproductive lifespan. Here to share key takeaways from her session at the 2025 Consortium of Multiple Sclerosis Centers Annual Meeting that focused on how we can better care for these patients is Dr. Riley Bove, a practicing neurologist and clinician scientist in the UCSF Weill Institute for Neurosciences.

For patients with who struggle with daily activities due to Parkinson's disease or essential tremor, treatment options are mostly limited to medication and invasive surgery. That's why Steadiwear co-founders Mark Elias and Emile Maamary developed an FDA-registered glove engineered to suppress hand tremors. Dr. Jerome Lisk sits down with Mr. Elias and Mr. Maamary to learn more about the device and its potential real-world impacts.