Nearly half of all patients with heart failure have preserved ejection fraction, or HFpEF, yet there is much that is unknown about HFpEF and how to best prevent it and treat it. Northwestern Medicine cardiologist, Sanjiv Shah, MD, leads the world's first clinical program dedicated to the study of heart failure with HFpEF. He discusses latest discoveries on the mechanisms of HFpEF and identifying therapeutic targets for it.