In this episode, Catherine C. Coombs, MD, and Toby Eyre, MBChB, MD, discuss key trials presented at ICML 2023 evaluating the use of BTK inhibitors in mantle cell lymphoma (MCL). The discussion includes analyses of: 

• Phase II trial of acalabrutinib with rituximab for older patients with untreated MCL 
• BRUIN: updated results of pirtobrutinib in covalent BTK inhibitor–pretreated MCL 
• IMCL-2015 GELTAMO: 5-year update ibrutinib for untreated indolent MCL 

Presenters: 

Catherine C. Coombs, MD, MS
Associate Clinical Professor
Division of Hematology/Oncology, Department of Medicine
UCI Health
Orange, California

Toby Eyre, MBChB, MD
Honorary Senior Lecturer
Hematology and Cancer
University of Oxford
Consultant Hematologist
Department of Hematology
Hematology and Cancer Centre, Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom