According to the CDC’s press release from September 2022, the leading underlying causes of pregnancy-related death include mental health conditions (including deaths to suicide and overdose/poisoning related to substance use disorder), accounting for 23% of cases. The top 2 perinatal, mental health conditions are anxiety and depression. And, although much more rare with an incidence of 1–2/1,000, postpartum psychosis is a major cause of self-harm an infant harm. In this episode, we will review “The College’s” recent clinical practice guidelines on mental health therapies in the perinatal interval. Do you know which 2 classes of medications are most preferred for treating anxiety/depression in the perinatal period? Are SSRIs a leading cause of PPHN? Is Lithium allowed in pregnancy? And what is “neonatal adaptation syndrome”? We will cover all these questions, and more, in this episode.