Cathleen McCabe, MD, joins Blake Williamson, MD, MPH, and Gary Wörtz, MD, to discuss the challenges of moving across the country from an existing practice and referral network and starting in a new state. She shares insights into the dynamics of changing ownership and having a clear outline for the type of practice to join. Drs. McCabe, Williamson, and Wörtz further discuss the pros and cons of different business models and pearls for making decisions and taking risks with business in ophthalmology.