Dr. Boghuma Titanji, Assistant Professor of Medicine at the Emory University School of Medicine, joins Javier Guzman to reflect on the ongoing monkeypox outbreak and response. Together they discuss the parallels between monkeypox and previous infectious disease outbreaks such as COVID-19; inequities in access to vaccines and treatments; and the role national, regional, and international entities must play in preparedness and response to avoid making the same mistakes when the next—inevitable—pandemic hits.