PedsCrit

This episode is produced in collaboration with WFPICCS (the World Federation of Pediatric Intensive and Critical Care Societies) showcasing the talks you can look forward to at WFPICCS 2026 in Melbourne, September 27–30. 

Dr. Sarah Seaton is an Associate Professor in Perinatal and Paediatric Research at the University of Leicester in the UK. She earned her undergraduate degree in Mathematics from the University of Wales, followed by a MSc in Medical Statistics and a PhD at Leicester. 

Dr. Seaton serves as the co-principal investigator of the Paediatric Intensive Care Audit Network (PICANet), an international audit of all paediatric intensive care delivered in the UK and Ireland. Prior to PICANet, she held three fellowships funded by the National Institute for Health Research, including an Advanced Fellowship in 2024 which aimed to investigate the transition from neonatal to paediatric care.

Reference:

https://www.picanet.org.uk/

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Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Ryan Coleman, MD is an Associate Professor of Pediatrics at Baylor College of Medicine with dual appointments in Critical Care Medicine and Pulmonary Medicine at Texas Children’s Hospital in Houston. He earned his medical degree from the University of Texas Health Science Center at San Antonio School of Medicine, completed pediatric residency and pediatric critical care fellowship training at Baylor College of Medicine, and holds additional training in pediatric bioethics. Dr. Coleman is board-certified in general pediatrics and pediatric critical care medicine and focuses his clinical and research efforts on pediatric extracorporeal membrane oxygenation (ECMO), severe pulmonary hypertension and right heart failure, and bioethical issues in critically ill children.

Learning Objective: By the end of this podcast, listeners should be able to discuss an evidence-based and expert-guided approach to the hemodynamic resuscitation of a child with high-risk pulmonary embolism and acute right heart failure.

References:

Ross C, Kumar R, Pelland-Marcotte MC, Mehta S, Kleinman ME, Thiagarajan RR, Ghbeis MB, VanderPluym CJ, Friedman KG, Porras D, Fynn-Thompson F, Goldhaber SZ, Brandão LR. Acute Management of High-Risk and Intermediate-Risk Pulmonary Embolism in Children: A Review. Chest. 2022 Mar;161(3):791-802. doi: 10.1016/j.chest.2021.09.019. Epub 2021 Sep 26.

Monagle P, Cuello CA, Augustine C, Bonduel M, Brandão LR, Capman T, Chan AKC, Hanson S, Male C, Meerpohl J, Newall F, O'Brien SH, Raffini L, van Ommen H, Wiernikowski J, Williams S, Bhatt M, Riva JJ, Roldan Y, Schwab N, Mustafa RA, Vesely SK. American Society of Hematology 2018 Guidelines for management of venous thromboembolism: treatment of pediatric venous thromboembolism. Blood Adv. 2018 Nov 27;2(22):3292-3316. doi: 10.1182/bloodadvances.2018024786.

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How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Charles Berde, MD, PhD, is the Sara Page Mayo Chair in Pediatric Pain Medicine and a Professor of Anaesthesia at Harvard Medical School. As a co-founder of the Pain Treatment Center at Boston Children's Hospital, he has spent decades at the forefront of pediatric analgesic pharmacology and the development of novel local anesthetics. His extensive translational research focuses on local anesthetic mechanisms and prolonged-duration formulations, making him a preeminent authority on the physiological impacts and safety profiles of these agents in neonates and children. A recipient of the Myron Yaster Lifetime Achievement Award from the Society for Pediatric Anesthesia, Dr. Berde brings unparalleled expertise to the discussion of managing and preventing local anesthetic systemic toxicity (LAST) within the high-stakes environments of the PICU and pediatric operating rooms.

Guest Conflicts of Interest (COI)

• Algavita Bio: Collaborator/Developer of novel, prolonged-duration local anesthetics.
• Quiver Bioscience: Unpaid Scientific Advisor and co-PI on an NINDS-HEAL grant focused on rare disease pain treatments.
• Latigo Biotherapeutics: Scientific Advisor and recipient of past research support for novel analgesics development.
• Algos: Scientific Advisor for non-opioid analgesics development.

Learning Objective: By the end of this podcast, listeners should be able to discuss an evidence-based and expert-guided approach to the management of local anesthetic systemic toxicity (LAST) in children.

References:

Patient and Doctor Reconcile for Greater Good

Berde CB. Toxicity of local anesthetics in infants and children. J Pediatr. 1993 May;122(5 Pt 2):S14-20. doi: 10.1016/s0022-3476(11)80004-1.

McMahon K, Paster J, Baker KA. Local anesthetic systemic toxicity in the pediatric patient. Am J Emerg Med. 2022 Apr;54:325.e3-325.e6. doi: 10.1016/j.ajem.2021.10.021. Epub 2021 Oct 25. 

Lavonas et al. 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the AHA Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2023 Oct 17;148(16):e149-e184. doi: 10.1161/CIR.0000000000001161. Epub 2023 Sep 18. 

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How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

About our Guests: 

Fran Balamuth, MD, PhD, MSCE, is division chief of Pediatric Emergency Medicine at the Children’s Hospital of Philadelphia. Dr. Balamuth’s research interests focus on pediatric sepsis recognition using epidemiologic and translational approaches, for which she has received NIH and foundation funding. She is the co-PI of the PROMPT BOLUS trial, a multinational pragmatic trial comparing saline vs balanced fluids in pediatric sepsis, which will be the largest acute care pediatric trial in history. In addition, she co-leads the CHOP Pediatric Sepsis Program, which supports and promotes local clinical, research, educational, and quality-improvement initiatives related to sepsis. She is an internationally recognized sepsis leader, and has been invited to serve on the national steering committee for the Improving Pediatric Sepsis Outcomes quality collaborative through the US Children’s Hospital Association, and 2 international task forces focused on defining pediatric sepsis through the US Centers for Disease Control and Prevention and the Society of Critical Care Medicine.

Scott L. Weiss, MD, MSCE, FCCM, is a Professor of Pediatrics & Pathology and Genomic Medicine at Thomas Jefferson University and division chief of Critical Care Medicine at Nemours Children’s Hospital, Delaware. Previously, Dr. Weiss was on the faculty at the Children’s Hospital of Philadelphia, where he earned recognition as an international expert in pediatric sepsis. Dr. Weiss’ NIH-funded research focuses on epidemiology, fluid resuscitation, and mitochondrial dysfunction in pediatric sepsis. Dr. Weiss is an international expert in pediatric sepsis and served as the co-PI of the PRoMPT BOLUS trial.

Nathan Kuppermann, MD, MPH, is Executive Vice President and Chief Academic Officer of Children's National Hospital and Director of the Children's National Research Institute. He also serves as chair of the Department of Pediatrics and associate dean of Pediatric Academic Affairs at the George Washington University School of Medicine and Health Sciences. He is an internationally recognized clinical trialist in pediatric trauma, pediatric DKA, and acute pediatric infections. As the original chair of the Pediatric Emergency Medicine Applied Research Network (PECARN); his research is focused on clinical trials and clinical prediction rules using large cohorts of acutely ill and injured children. Dr. Kuppermann served as the senior investigator of the PRoMPT BOLUS trial.

Selected References:

1. Weiss SL, Balamuth F, Long E, Thompson GC, Hayes KL, Katcoff H, Cook M, Tsemberis E, Hickey CP, Williams A, Williamson-Urquhart S, Borland ML, Dalziel SR, Gelbart B, Freedman SB, Babl FE, Huang J, Kuppermann N; Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS) Investigators of the PECARN, PERC, and PREDICT Networks. PRagMatic Pediatric Trial of Balanced vs nOrmaL Saline FlUid in Sepsis: study protocol for the PRoMPT BOLUS randomized interventional trial. Trials. 2021 Nov 6;22(1):776. doi: 10.1186/s13063-021-05717-4. Erratum in: Trials. 2025 Oct 7;26(1):390. doi: 10.1186/s13063-025-09164-3. PMID: 34742327; PMCID: PMC8572061.
2. Weiss SL, Balamuth F, Thurm CW, Downes KJ, Fitzgerald JC, Laskin BL. Major Adverse Kidney Events in Pediatric Sepsis. Clin J Am Soc Nephrol. 2019 May 7;14(5):664-672. doi: 10.2215/CJN.12201018. Epub 2019 Apr 18. PMID: 31000518; PMCID: PMC6500940.
3. Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, Stollings JL, Kumar AB, Hughes CG, Hernandez A, Guillamondegui OD, May AK, Weavind L, Casey JD, Siew ED, Shaw AD, Bernard GR, Rice TW; SMART Investigators and the Pragmatic Critical Care Research Group. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018 Mar 1;378(9):829-839. doi: 10.1056/NEJMoa1711584. Epub 2018 Feb 27. PMID: 29485925; PMCID: PMC5846085.

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How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Learn more about the ACTION learning network at this link.

About our Guest: 

Tanya Perry, DO, is the director of the VAD Program at Cohen Children’s Medical Center. She earned her medical degree from Nova Southeastern University and completed her pediatric critical care fellowship training at Cohen Children’s Medical Center, followed by pediatric cardiology fellowship at Cincinnati Children’s Hospital, where she subsequently practiced for 3 years as a cardiac intensivist. Dr. Perry’s clinical and research efforts are focused on improving outcomes in children supported with mechanical circulatory support. 

Selected References: 

Ventricular Assist Device Therapy - ClinicalKey

Berlin Heart EXCOR and ACTION post-approval surveillance study report - PubMed

ABCs of Stroke Prevention | Circulation: Cardiovascular Quality and Outcomes

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

About our Guest: 

Tanya Perry, DO, is the director of the VAD Program at Cohen Children’s Medical Center. She earned her medical degree from Nova Southeastern University and completed her pediatric critical care fellowship training at Cohen Children’s Medical Center, followed by pediatric cardiology fellowship at Cincinnati Children’s Hospital, where she subsequently practiced for 3 years as a cardiac intensivist. Dr. Perry’s clinical and research efforts are focused on improving outcomes in children supported with mechanical circulatory support. 

Learning Objectives:

By the end of this podcast, listeners should be able to:

1. Describe the common clinical scenarios that warrant VAD 
2. List the clinical factors impacting device selection 
3. Explain the independent and dependent variables associated with each device, as well as the cannulation strategy other important monitoring pearls 

Selected References: 

Ventricular Assist Device Therapy - ClinicalKey

Berlin Heart EXCOR and ACTION post-approval surveillance study report - PubMed

ABCs of Stroke Prevention | Circulation: Cardiovascular Quality and Outcomes

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Robert Pass is Professor of Pediatrics and Chief of the Division of Pediatric Cardiology at the Icahn School of Medicine at Mount Sinai and Mount Sinai Kravis Children’s Hospital. He is Co-Director of the Mount Sinai Kravis Children’s Heart Center and Director of Pediatric Electrophysiology at the Mount Sinai Health System. In addition to his exceptional clinical work as an electrophysiologist, he is the host of the very successful medical education podcast Pediheart: Pediatric Cardiology Today.

Learning Objective: By the end of this podcast, listeners should be able to discuss an evidence-based and expert-guided approach to the evaluation and management of high-grade atrioventricular block in children.

References:

PediHeart Podcast with Robert Pass

https://www.youtube.com/@RobertPassPediheart 

Kusumoto et al. 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. J Am Coll Cardiol. 2019 Aug 20;74(7):932-987.

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

About our Guests: 

Catherine Ross, MD, is a pediatric critical care physician in the Division of Medical Critical Care at Boston Children’s Hospital (BCH) and Assistant Professor at Harvard Medical School. She serves on the joint American Heart Association (AHA) and American Academy of Pediatrics national writing group for Pediatric Advanced Life Support 2025 guidelines as well as the AHA Emergency Cardiovascular Care Science Subcommittee and Pediatric Emphasis Group. Her research interests lie in pediatric resuscitation, specifically in designing and implementing high-quality randomized controlled trials in the pre- and intra-arrest periods. Specific areas of interest include peri-arrest bolus epinephrine, intra-arrest drug management, and massive pulmonary embolism in children.

Ryan Morgan is a pediatric intensivist and Associate Professor at the Children’s Hospital of Philadelphia, where he is the Associate Director of the CHOP Resuscitation Science Center and the Associate Division Chief for Faculty Affairs. He was a writing group member for the 2025 AHA/AAP PALS Guidelines and currently serves on the International Liaison Committee on Resuscitation’s Pediatric Life Support Task Force. Ryan's research focuses on intra-arrest physiology and on using physiology to guide resuscitation therapies. He is currently leading PEDICA, an NHLBI-funded study underway across 22 hospitals in the pediRES-Q network examining the physiologic effects of epinephrine during pediatric cardiac arrest.

Selected References: 

1. Cardiac Arrest Pharmacopeia, Critical Care Clinics, 2025
2. Peri-arrest bolus epinephrine practices amongst pediatric resuscitation experts - PMC Resusc Plus. 2022 
3. Physiologic response to pre-arrest bolus dilute epinephrine in the pediatric intensive care unit - PMC Resuscitation. 2018 
4. The physiologic response to epinephrine and pediatric cardiopulmonary resuscitation outcomes - PubMed Crit Care. 2023 
5. Comparison of vasopressin to epinephrine during pediatric in-hospital cardiac arrest: survival and physiologic responsiveness - PubMed Pediatric Research. 2025
6. Epinephrine Dosing Intervals Are Associated With Pediatric In-Hospital Cardiac Arrest Outcomes: A Multicenter Study - PubMed. Crit Care Med. 2024

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Dr. Merritt Tuttle is both a Pediatric Intensivist and Medical Toxicologist at Brenner Children's Hospital in North Carolina associated with Atrium Health and Wake Forest Baptist Health. She completed her Pediatric Critical Care and Medical Toxicology training at the Medical College of Wisconsin.

Learning Objective: By the end of this podcast, listeners should be able to discuss an evidence based and expert guided approach to the evaluation and management of the critically ill child with calcium channel blocker toxicity.

References:

St-Onge M, Anseeuw K, Cantrell FL et al, Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults. Crit Care Med. 2017 Mar;45(3):e306-e315.

2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care

Levine M, Curry SC, Padilla-Jones A, Ruha AM. Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center. Ann Emerg Med. 2013 Sep;62(3):252-8. doi: 10.1016/j.annemergmed.2013.03.018. 

Cole JB, Arens AM, Laes JR, Klein LR, Bangh SA, Olives TD. High dose insulin for beta-blocker and calcium channel-blocker poisoning. Am J Emerg Med. 2018 Oct;36(10):1817-1824. doi: 10.1016/j.ajem.2018.02.004. Epub 2018 Feb 6.

Slamowitz A, Sweberg T, Labgold K, Nickerson T. Extracorporeal Membrane Oxygenation for Calcium Channel Blocker Intoxication: A Multicenter Retrospective Registry Review. ASAIO J. 2025 Oct 31.

 
Poison Control: (800) 222-1222

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!

Ayesha Zia, MD, is a Professor of Pediatrics at UT Southwestern Medical Center and a nationally recognized expert in pediatric thrombosis, with particular emphasis on the diagnosis, management, and long-term outcomes of pulmonary embolism in children and adolescents. She serves as Director of the Pediatric Hemostasis and Thrombosis Program at Children’s Health Dallas. She has led the development of a collaborative multidisciplinary approach to pediatric PE care, including pulmonary embolism response teams. Her October 2025 publication in Blood “How I treat pediatric pulmonary embolism” is the topic of today’s discussion

Learning Objective: By the end of this podcast, listeners should be able to describe an evidence-based and expert-guided approach to the diagnosis, risk stratification and management of pulmonary embolism in children.

References:

Zia A, Goldenberg NA, Rajpurkar M. How I treat pediatric pulmonary embolism. Blood. 2025 Oct 2;146(14):1643-1653. doi: 10.1182/blood.2024026599. 

Dang MP, Cheng A, Garcia J, Lee Y, Parikh M, McMichael ABV, Han BL, Pimpalwar S, Rinzler ES, Hoffman OL, Baltagi SA, Bowens C, Divekar AA, Davis Volk AP, Huang CJ, Veeram Reddy SR, Arar Y, Zia A. Bringing PERT to Pediatrics: Initial Experience and Outcomes of a Pediatric Multidisciplinary Pulmonary Embolism Response Team (PERT). Chest. 2025 Mar;167(3):851-862.

Mercurio L, Corwin D, Kaplan R, Ellison AM, Casper TC, Kuppermann N, Kline JA. Bedside exclusion of pulmonary embolism in children without radiation (BEEPER): a national study of the Pediatric Emergency Care Applied Research Network-Study protocol. Res Pract Thromb Haemost. 2023 Jan 14;7(2):100046. 

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Support the show

How to support PedsCrit:
Please complete our Listener Feedback Survey
Please rate and review on Spotify and Apple Podcasts!
Donations are appreciated @PedsCrit on Venmo , you can also support us by becoming a patron on Patreon. 100% of funds go to supporting the show.

Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at [email protected].  You can also check out our website at http://www.pedscrit.com. Thank you for listening to this episode of PedsCrit!