Tranexamic acid, which frustrates clot dissolution, has been shown to reduce death from intracranial bleeding in a large international placebo-controlled trial — “CRASH-3.”

Ali Raja and Joe Elia host a lively chat with Ian Roberts, the co-chair of the trial’s writing committee, who, in addition to chastising the hosts’ seeming fascination with P-values, recounts a story from early in his training that first stirred his devotion to preventing bleeding-related death after trauma.

NEJM Journal Watch Emergency Medicine summary of CRASH-3

CRASH-3 report in The Lancet

Ian Roberts explains CRASH-3 on YouTube to collaborators in Malaysia

Roberts presents CRASH-3 results at World Congress on Intensive Care on YouTube

Running time: 23 minutes