NEJM Journal Watch Podcasts: Clinical Conversations

Podcast 293: HER2-“low” breast cancer and its reponse to an antibody-drug conjugate


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Patients with metastatic breast cancer whose tumors express low levels of HER2 are generally classified and treated as having HER2-negative disease. However, Dr. Shanu Modi of the Memorial Sloan Kettering Cancer Center and a group of international collaborators explored the use of a monoclonal antibody–drug conjugate (trastuzumab–deruxtecan) in patients with disease they classify as HER2-“low.” Compared […]
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