Author: Jared Scott, M.D.

Educational Pearls:

• Recent study compared Compazine with Benadryl vs. Dilaudid for acute migraine management in the ED.

• Compazine + Benadryl demonstrated migraine relief in 60% of patients compared to the 31% of patients who were relieved with Dilaudid.

• Compazine + Benadryl is a superior migraine treatment than Dilaudid.

References:

Friedman BW, et. al. (2017). Randomized study of IV prochlorperazine plus diphenhydramine vs IV hydromorphone for migraine. Neurology. 89(20):2075-2082