Contributor: Nick Tsipis, MD

Educational Pearls:

• Observational study in Israel evaluated cohort of vaccinated pregnant women receiving the initial Pfizer-BioNTech COVID-19 mRNA vaccine
• Looked at 24,288 newborns with about 16,697 exposed to maternal vaccination in utero
• Longitudinal follow up showed no significant difference in preterm births, neonatal hospitalizations, post-natal hospitalizations, congenital abnormalities, or mortality
• While this is not a randomized-controlled trial, this observational trial has a very large population that was studied supporting the safety profile of birth outcomes relating to receiving COVID mRNA vaccines during pregnancy

References

Goldshtein I, Steinberg DM, Kuint J, et al. Association of BNT162b2 COVID-19 Vaccination During Pregnancy With Neonatal and Early Infant Outcomes [published online ahead of print, 2022 Feb 10]. JAMA Pediatr. 2022;e220001. doi:10.1001/jamapediatrics.2022.0001

Summarized by John Spartz, MS4 | Edited by Erik Verzemnieks, MD

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