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Editor-in-Chief, Robert Amdur, MD, discusses primary radiotherapy for early-stage Non-Hodgkin’s Lymphoma of Early Stage and Indolent Histology. The discussion begins with an explanation of lymphoma classification and then reviews two papers published in PRO:"Prognostic Effect of Systemic Therapy and Radiation Therapy in Stage I Nodal Marginal Zone Lymphoma" (2023, Issue 1, January/February) and "Underutilization of Radiation Therapy in Early-stage Marginal Zone Lymphoma Negatively Impacts Overall Survival" (2016, Issue 4, July/August).