Proactive - Interviews for investors

Imugene Ltd (ASX:IMU OTCMKTS:IUGNF) CEO Leslie Chong sits down with Proactive’s Jonathan Jackson after the company dosed the first patient in the intravenous (IV) infusion combination arm of its Phase 1 onCARlytics trial. The patient, diagnosed with cholangiocarcinoma, received treatment at City of Hope in California.

Imugene’s OASIS trial is the first to combine a CD19-expressing oncolytic virus with a CD19-targeting drug. Chong stated that the enrolment of the first IV combination patient advanced the OASIS trial, which integrated their CD19 oncolytic virus with the CD19 bispecific drug, blinatumomab (Blincyto®), in patients with advanced solid cancers.

The Phase 1 trial aims to evaluate the safety and efficacy of onCARlytics (CF33-CD19) administered via intratumoural (IT) injection or IV infusion. The treatment may be given alone or with blinatumomab. Currently, the trial is being conducted at City of Hope, University of Cincinnati, and MD Anderson Cancer Center, with plans to expand to 10 sites to recruit 40-45 patients with advanced solid cancers.

The primary objective is to assess the safety and efficacy of onCARlytics via IT or IV routes, as monotherapy or in combination with blinatumomab. The trial began dosing its first IV monotherapy patient with bile tract cancer in February, with early combination data expected by Q4 2024.

CD19 is a significant target for blood cancers, representing about 10% of all cancers. However, solid cancers lack a common surface target. onCARlytics aims to convert solid tumours into CD19-expressing tumours, making them treatable with CD19-targeting therapies. If successful, this approach could extend CD19 therapies to 90% of the cancer market, valued at US$532 billion by 2032.

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Cordiant Digital Infrastructure Joint Managing Directors Steven Marshall, Benn Mikula and Chief Financial Officer Mark Tiner joined Steve Darling from Proactive to discuss the company's impressive financial results and strategic initiatives. Steven Marshall announced a total return for the year of 9.3%, increasing NAV per share to 120.1p. The total dividend for the year increased 5.0% to 4.2p, ahead of guidance; 4.4x covered by earnings and 1.6x covered by adjusted funds from operations.

Tiner noted that the 9.3% return could have reached 11% if not for adverse foreign exchange impacts. The portfolio's aggregate EBITDA grew by 7.2% on a like-for-like basis. Benn Mikula elaborated on the company's strategy of providing investors with exposure to diversified digital infrastructure, including fibre optic cables, data centers, and communication towers.

Cordiant's assets span across North America and Europe, providing essential infrastructure for the digital economy. The company's conservative valuation approach offers both diversification and growth. Marshall praised the exceptional management teams overseeing assets in the Czech Republic, Poland, and Ireland. These teams have driven revenue growth and strategic acquisitions, such as expanding cloud services in the Czech Republic and acquiring communication towers in Poland. Cordiant Digital Infrastructure's robust financial performance and strategic initiatives highlight the company's commitment to growth and its pivotal role in the digital infrastructure sector.

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Gold Royalty Corp CEO David Garofalo joined Steve Darling from Proactive to share exciting news about the company's strategic developments. Gold Royalty Corp has completed its previously announced acquisition of a copper stream, operated by a subsidiary of Adriatic Metals plc and located in Bosnia and Herzegovina. The Vares Stream pertains to 100% of the copper production from the mining area over the Rupice deposit. This stream includes ongoing payments equal to 30% of the London Metal Exchange (LME) spot copper price, with the effective payable copper fixed at 24.5%.

Garofalo provided further details, stating that Adriatic has offered production guidance of 240-300 kilotons (kt) of ore to be mined from Vares in 2024, with copper grades ranging from 0.5-0.6%. Adriatic forecasts 750-850 kt and 800-900 kt of ore to be mined in 2025 and 2026, respectively, at grades of 0.5-0.7% copper. The company also mentioned that recent guidance targets a mine life of 18 years with an attractive operating cost profile.

Garofalo highlighted the remarkable growth Gold Royalty Corp is experiencing, expanding from 18 development-stage royalties to 240 royalties, which now include 5 producing projects. In 2024, Gold Royalty Corp expects 160% growth in revenue and anticipates positive free cash flow and earnings for the first time. The company projects a 60% compounded annual growth rate in revenue through the end of the decade, driven by royalties on major gold mines in North America.

These developments underscore Gold Royalty Corp's strategic focus on expanding its portfolio and enhancing its revenue streams through significant acquisitions and robust growth in its royalty assets.

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EuroPacific Metals CEO Karim Rayani joined Steve Darling from Proactive to announce the expansion of the company's drill program at the Miguel Vacas mine area. The expansion includes an additional drill hole extending down to 350 meters, targeting the high-grade zone below the fourth hole where the company previously intersected a mineralized section. This new hole will also target a section approximately 80 meters north, where the results of the first hole showed 22.8 meters grading 2.76% copper, including 9.0 meters grading 7.49% copper.

Rayani explained that a decision was made to extend the drilling program by adding an undercut inclined 350-meter hole to test the "fresh" mineralization below the oxidized rich material in the same section as hole EBMV004, which revealed a wide mineralized section.

The mineralized system at Miguel Vacas extends at least 2 kilometers along strike and remains open at depth. It includes an 80-meter supergene blanket containing a suite of copper carbonates, phosphates, and oxides, which gradually transitions to a sulphide assemblage primarily composed of chalcopyrite and pyrite. To date, the company has completed 10 holes at the Miguel Vacas copper deposit, totaling 1,060 meters.

This expanded drilling program underscores EuroPacific Metals' commitment to thoroughly exploring and developing the Miguel Vacas mine area, aiming to uncover substantial copper resources and enhance the project's overall value.

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Fathom Nickel CEO Ian Fraser joined Steve Darling from Proactive to announce that the company has secured all necessary permits to advance its exploration activities at the Gochager Lake project. This project, which hosts an historic NI43-101 non-compliant open-pit resource consisting of 4.3 million tons at 0.295% nickel and 0.081% copper, will now see significant development.

The newly acquired permits enable Fathom Nickel to drill up to 60 drill holes and construct an all-season, 25-person camp. Additionally, the company has received permission to use temporary "fly camps" during the summer-fall field season. These camps will support site-specific airborne geophysical anomaly follow-ups, mapping and prospecting, soil geochemistry, and site-specific geophysical surveys. The exploration permit is valid for two years, expiring in 2026.

Fraser also shared that the company mobilized field crews last week to begin a soil geochemical survey. The objective is to define a soil geochemical signature associated with the Gochager Lake deposit and use this signature to locate additional similar deposits. Detailed mapping, prospecting, and soil geochemical sampling will focus on areas of conductivity identified through surface time-domain electromagnetic surveys conducted last season. Moreover, the company plans to conduct a detailed drone-MAG survey over the historic Gochager Lake deposit area, covering approximately 385 line-kilometers.

These advancements mark a pivotal step in Fathom Nickel's exploration strategy, underscoring the company's commitment to expanding its resource base and uncovering new mineral deposits at Gochager Lake.

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IQ-AI subsidiary Imaging Biometrics Medical Oncologist and Emeritus Professor at the Medical College of Wisconsin Dr. Christopher Chitambar joined Steve Darling from Proactive to provide an update on the company's oncology-focused drug, oral gallium maltolate, as it nears the end of its Phase 1 clinical trial. This study is designed to treat groups of patients with relapsed glioblastoma brain tumors using varying doses of oral GaM over a minimum period of two months. The primary goals are to evaluate drug toxicity, assess patient tolerance to the treatment, and establish a recommended dose for a Phase 2 clinical trial.

Historically, patients with relapsed glioblastoma experience disease progression within one to six months following relapse. However, the Phase 1 trial yielded promising results, with some patients remaining on treatment without disease progression for over six months. Remarkably, one patient showed no progression for more than a year. The full results of this Phase 1 study are currently being compiled and are expected to be published by spring 2025.

Dr. Chitambar also discussed the preparations for the Phase 2 trial, which the clinical team has already begun defining. This multi-center trial is expected to span approximately three years and will aim to enroll 50-60 patients. The primary endpoint will be overall survival. The ongoing access to the FDA under Fast Track designation will facilitate the identification of intermediate endpoints, potentially compressing the timeline and expediting the approval process. End-of-phase 1 and phase 2 meetings with the FDA are crucial, and the team anticipates scheduling their end-of-phase 1 meeting as the data analysis from Phase 1 nears completion.

This update highlights the significant progress Imaging Biometrics is making in developing a promising treatment for glioblastoma, offering hope for improved outcomes in this challenging area of oncology.

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HeLIX Exploration PLC chairman David Minchin joined Proactive's Stephen gunnion with details of the company's acquisition of the Rudyard project in Hill Country, Montana.

Minchin shared details of this major helium project, highlighting that the acquisition cost was $250,000, with 60% paid in shares.

"This is an acquisition of a proven discovery with helium in its flowed helium gas to the surface, 1.3% helium with good flow rates. It has contingent resources of about half a billion cubic feet," said Minchin. He emphasized the project's potential, stating the in-situ value of the helium is approximately $250 million.

Minchin also discussed Helix's diversification strategy, aiming to establish two production hubs by 2025, which would enhance their leverage in negotiating debt finance and ensure a consistent supply for end users. He noted the company's fully funded drilling and appraisal plans, supported by an oversubscribed IPO, which ensures sufficient cash flow for ongoing and future operations.

He said Helix is optimistic about the complementary nature of this acquisition to its existing Ingomar Dome project and looks forward to advancing its drilling plans in the newly acquired area. The existing infrastructure, including three-phase electrics and easy access to the southern edge of the property, will facilitate a low-cost development for the company.

For more updates, visit Proactive's YouTube channel, like the video, subscribe to the channel, and enable notifications for future content.

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Magnetite Mines Ltd CEO Tim Dobson talked with Proactive about the company’s recent announcement of a $5 million rights issue. The funds will be used for working capital and advancing the Razorback project to the next stage. Eligible shareholders can purchase shares at $0.31 each, a 16.1% discount on the recent average price.

Dobson highlighted the participation of the company's senior management in the offer, reflecting their confidence in the project's trajectory. He also detailed the use of previously raised funds to clear debt and progress government approvals and metallurgical test work. Significant progress has been made in optimizing the project, with a focus on producing high-quality magnetite concentrates and exploring cost-saving innovations like saline water processing.

Moreover, Dobson shared that Magnetite Mines is in advanced negotiations with two strategic partners for substantial funding towards the final investment decision. He emphasized the alignment with both state and federal government initiatives to develop a green iron industry by 2030.

In conclusion, Dobson underscored the company's commitment to moving forward with project approvals, positioning Magnetite Mines as a key player in the emerging green iron industry in Australia. "We have one of the best quality and largest deposits to feed this industry in Australia," said Dobson.

Visit Proactive's YouTube channel for more videos. Don't forget to give the video a like, subscribe to the channel, and enable notifications for future content.

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Electric Guitar PLC (AIM:ELEG) CEO John Regan talked with Proactive's Stephen Gunnion about the company's new collaboration with Digital Alchemy to enhance client acquisition and engagement.

Digital Alchemy provides a comprehensive data platform that optimises advertising campaigns, making it a crucial part of Electric Guitar's strategy.

Regan explained, "By working with businesses like Digital Alchemy, we can engage with prospects at a strategic point, making our clients much more sticky." This partnership is expected to drive significant growth, especially in North America and the Asia-Pacific region, where Digital Alchemy has substantial reach.

Regan also highlighted the immediate impact of this collaboration, noting, "I got my first lead from them last night." This rapid result showcases the potential for quick wins from the partnership.

Additionally, the interview covered the resignation of David Eldridge, a non-executive director, who played a key role during Electric Guitar's cultural shift and 3radical reverse takeover.

For more insights and updates from Electric Guitar PLC, make sure to give this video a like, subscribe to Proactive's YouTube channel, and enable notifications for future content.

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The FTSE 100 opened modestly higher ahead of the Bank of England's rate decision later today.

In early trade, the index was up just under a quarter of a percent at 8,223.

Among the movers, Sainsbury's is top of the leaderboard, up 2% after agreeing a deal to offload its core banking business to NatWest Group, even though it had to pay the lender £125 million to do it.

CMC Markets PLC jumped 9.1% after following the recent deal with Revolut by announcing full-year results well ahead of consensus forecasts.

Alpha Financial Markets Consulting is up another 3% on top of yesterday big jump, with the board formally backing a £626 million takeover by private equity group Bridgepoint.

The fund management consultant said investors will receive 505p a share in cash, with the transaction expected to be completed in the third quarter, subject to a shareholder vote.

On the downside, Tate & Lyle fell close to 7% as investors don't seem to like the sound of its $1.8 billion acquisition of US rival CP Kelco and £215 million share buyback.

And YouGov plunged 41% after issuing a profit warning due to lower sales, mostly in continental Europe.

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