Proactive - Interviews for investors

Race Oncology Ltd (ASX:RAC) chief medical officer Dr Michelle Rashford joins Proactive’s Meagan Evans to discuss the appointment of global contract research organisation George Clinical International to support the clinical development of its RC220 bisantrene as a cardioprotective and anticancer treatment in solid tumour patients. This decision followed an extensive selection process by Race Oncology's clinical team.

Dr Rashford expressed enthusiasm for the partnership, highlighting George Clinical's responsiveness and clinical insight. The Phase 1a/1b trial will target advanced solid tumour patients in Australia, Hong Kong and South Korea, focusing on those indicated for doxorubicin treatment. The study aims to deliver human safety and pharmacokinetic data, determine optimal dosing with doxorubicin and gather initial human results on the cardioprotective, anti-cancer and m6A RNA activity of RC220 bisantrene.

George Clinical was chosen for its extensive trial experience and successful track record in oncology trials across multiple regions. The trial will be conducted in two stages across multiple sites, employing a Bayesian design for flexibility and speed. The Phase 1a stage will assess safety, tolerability, pharmacokinetics, m6A RNA effects and the maximum tolerated dose. The Phase 1b stage will evaluate the optimal dosage of RC220 bisantrene in combination with doxorubicin.

The trial's final protocol and commencement are pending human ethics and institutional approvals. Race Oncology has begun engagement with George Clinical under a Start-Up Agreement (SUA) valued at A$1,071,067, with further payments under a master service agreement (MSA) as key milestones are achieved. The estimated total cost of the Phase 1 trial is A$6 million.

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Australian Gold and Copper Ltd (ASX:AGC) managing director Glen Diemar joins Meagan Evans in the Proactive studio to discuss the discovery of the widest zone of high-grade mineralisation reported to date at its Achilles site in the southern Cobar Basin, NSW. Recent drilling results from six of nine holes showed significant findings, including 16 metres at 18.5% lead+zinc, 0.4 g/t gold, 31 g/t silver and 0.8% copper from 91 metres. The highest grades were 47.1% lead+zinc, 761 g/t silver, 4.1 g/t gold and 2.5% copper in various intervals of hole A3RC038, the most northern hole drilled.

The discovery, now defined by 12 drill holes over half a kilometre, remains open in multiple directions. All 12 holes exhibited varying mineralisation levels, indicating substantial near-surface and depth potential. Notably, hole A3RC038 contained a 16-metre high-grade zone within a broader 24-metre mineralised section, highlighting the Achilles deposit's potential for significant volumes of high-grade mineralisation.

Permits for an additional 30 drill holes have been obtained, with drilling set to commence shortly. The new program will include up to 20 reverse circulation holes and 10 diamond core holes aimed at extending the deposit's strike length and depth, as well as exploring nearby targets. A follow-up IP survey will begin next month to map the Achilles Shear Zone.

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Standard Uranium Vice President of Exploration Sean Hillacre joined Steve Darling from Proactive to provide a detailed summary of the analytical results from the inaugural winter 2024 drill program at the Atlantic Project in Saskatchewan. The results highlight significant uranium mineralization across multiple drill holes, marking a promising development for the project.

The Atlantic Project, currently under option to ATCO Mining, which funded the 2024 drill program, has confirmed highly anomalous uranium in drill holes ATL-24-002, ATL-24-004A, and ATL-24-005A. These findings align with prospective structural zones and favorable alterations, including dravite-rich clays. Multiple zones of elevated uranium were intersected, linked to the sub-Athabasca unconformity and basement structural zones, indicating the presence of a uranium-fertile system.

Hillacre expressed optimism about the significant discovery potential along the untested portions of the east-west conductor system within the Atlantic Project. The company is planning supplementary geophysical surveys over the central claim blocks, which will provide additional target areas for phases II and III of the drilling program. These surveys aim to explore further the untested gravity low anomalies on the western block, potentially unveiling more high-value uranium zones.

Standard Uranium's continued exploration efforts at the Atlantic Project highlight the substantial upside for new discoveries and reinforce the project's strategic importance in the company's portfolio. The positive results from the winter 2024 drill program lay a strong foundation for future exploration and development activities in this highly prospective region.

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Arrow Exploration CEO Marshall Abbott joined Steve Darling from Proactive to share significant updates on the company's operational activities, focusing on the multi-horizon Carrizales Norte field in the Tapir Block, located in the Llanos Basin of Colombia. Arrow has successfully commenced production from the first of four planned Ubaque horizontal wells for 2024. This inaugural horizontal well on the Carrizales Norte "B" pad has exceeded expectations, achieving a restricted flow rate of 3,150 barrels of oil per day (BOPD) gross, with less than 1% water cut while still recovering load fluid.

Abbott detailed that this well was drilled to a total measured depth of 11,680 feet, featuring a horizontal section of approximately 2,042 feet. The pay zone is composed of clean sandstone, exhibiting consistent 28% porosity and high resistivity, characteristics similar to those observed in previous wells.

The drilling rig has now been relocated to the second cellar on the Carrizales Norte B Pad. The company plans to drill a dedicated water disposal well (CNB-2) next. Following this, Arrow Exploration intends to drill three additional horizontal wells on the B pad, with longer horizontal sections expected to enhance production rates and ultimate recovery. Additionally, the company will drill the Baquiano-1 exploration well, which aligns with the trend of the Carrizales Norte field.

These developments underscore Arrow Exploration's strategic efforts to optimize production and enhance recovery rates at the Carrizales Norte field, reinforcing the company's commitment to expanding its operational footprint and maximizing resource extraction in the Llanos Basin.

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G Mining Ventures Corp CEO Louis-Pierre Gignac joined Steve Darling from Proactive to share an encouraging update on the commissioning progress of the Tocantinzinho Gold Project in Brazil. This ambitious project is designed to produce approximately 175,000 ounces of gold annually over its initial 10.5-year mine life and remains on track and within budget for commercial production in the second half of this year.

Gignac informed Proactive that ore was introduced into the grinding circuit on June 10, following the receipt of the hot commissioning permit from the Pará State Environmental Agency (SEMAS). These permits allow for the mining and processing of ore, disposal of tailings, as well as the selling and exporting of gold. Once the project reaches a steady state, the Tocantinzinho Gold Project (TZ) is set to become Brazil’s third-largest primary gold mine.

To date, approximately 2.0 million tonnes of ore have been stockpiled. This includes 1.5 million tonnes grading 0.77 g/t Au in the low-grade stockpile and 0.5 million tonnes grading 1.29 g/t Au in the high-grade stockpile. The initial phase of hot commissioning will utilize the low-grade stockpiled ore, with plans to progressively feed higher-grade ore as production ramps up. The goal is to achieve a planned throughput of 4.7 million tonnes per year, advancing towards the higher-grade hard rock as mining operations progress.

Additionally, Gignac highlighted a merger with Reunion Gold, involving their Oko West project in Guyana. This merger aims to create a larger company and achieve gold production of at least 500,000 ounces annually from the combined assets. The transaction is pending shareholder approval, with a meeting scheduled for July 9th.

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AgEagle Aerial Systems CEO Bill Irby joined Steve Darling from Proactive to announce a significant new contract for the company. AgEagle has secured a purchase order to deliver 20 eBee VISION full-stack systems, including control systems, batteries, backpacks, and limited spares, to a leading distributor in the United Arab Emirates. This contract is valued at approximately $2 million for the fiscal year 2024. The company operates three centres of excellence concentrating on drones, specialty cameras, and control software. The company delivers fully integrated systems combining sensors, aircraft, robotic technologies, and control systems.

Irby emphasized that this contract underscores the global need for enhanced public safety and security. The deal supports a government customer with best-in-class UAV defense solutions for intelligence, surveillance, and reconnaissance missions.

This announcement follows closely on the heels of another milestone for AgEagle: the U.S. Army Corps of Engineers (USACE) recently completed training for National Guardsmen using AgEagle's eBee TAC drone. This drone, which is NDAA-compliant, is the first fixed-wing UAV to be added to the Defense Innovation Unit (DIU) Blue UAS list and cleared to fly over humans.

Looking forward, AgEagle aims to maintain its growth in the military domain while continuing to support its legacy customers in agriculture and other civil sectors. The primary goal for the remainder of the year and into 2025 is to fulfil customer commitments and further develop their strategic plans.

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Robin Abeyesinhe, managing director of TCAT, a subsidiary of One Media iP Group PLC (AIM:OMIP), tells Proactive's Stephen Gunnion the company has extended the free trial period for its new TCAT Protect app to 14 days, followed by six months of free access to the Bronze plan.

The TCAT Protect app helps users manage their content and identify potentially infringing material across digital service providers (DSPs) worldwide. As Abeyesinhe explained, "it's a tool for effectively managing your content and seeing where it is available online." The extension aims to attract a broader audience, including solo artists, bands, and indie labels, through a parallel social media and PR campaign.

The Bronze plan, which follows the initial 14-day trial, allows users to upload up to ten tracks and provides substantial functionality without requiring credit card information. Abeyesinhe emphasised that this initiative helps demonstrate TCAT's value, encouraging users to eventually upgrade to the Silver and Gold plans.

The discussion also highlighted TCAT's unique fingerprinting technology, which identifies where tracks are available and flags potentially infringing content. This information helps rights holders take necessary actions to protect their work.

You can view a full demo of TCAT Protect by following this link: https://youtu.be/KHhZ03CsKtg

Visit Proactive's YouTube channel for more videos. Don't forget to like this video, subscribe to our channel, and enable notifications for future updates.

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Rainbow Rare Earths Ltd (LSE:RBW, OTC:RBWRF) CEO George Bennett joined Proactive's Stephen Gunnion with details of the positive results of a 70-day pilot test at the Phalaborwa rare earths project, highlighting key optimisations that have led to significant operational improvements.

"During the piloting, we recognised some key optimisation opportunities and with that we ran the pilot plant far longer but those optimisation opportunities have delivered very, very good results," he stated.

These optimisations include a 50% reduction in heating requirements and leaching tanks, as well as the use of lower-grade, more cost-effective materials. An interim report, expected later this year, will reflect these improvements and support the company's low-cost production goals.

Bennett also mentioned plans to proceed with project financing ahead of the final DFS next year, with ongoing optimisations in reagent use and material purity targets.

"We have achieved 95% purity on the first pass, moving towards our 99.5% target," Bennett noted.

For more details on Rainbow Rare Earths' progress, watch the full interview.

Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel, and enable notifications for future content."

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Hemogenyx Pharmaceuticals PLC (LSE:HEMO, OTC:HOPHF) CEO Dr Vladislav Sandler talked with Proactive about the company's recent operations update. In the interview, Sandler detailed three key areas of focus: the HEMO-CAR-T program, the CBR platform, and CDX bispecific antibodies.

Starting with the HEMO-CAR-T program, Hemogenyx has added an additional clinical trial site at a prestigious US medical center. Sandler emphasised that this expansion will enhance the trial's scope and speed up the timeline. He also revealed plans to include pediatric indications, potentially transforming treatment options for children with acute myeloid leukemia and acute lymphoblastic leukaemia.

Sandler provided insights into the CBR (Chimeric Bait Receptor) platform, describing it as an advanced immunotherapy aimed at reprogramming innate immune cells to combat infections and certain cancers. The platform is in the development and testing phase, with promising results so far.

Lastly, Dr Sandler discussed progress with KD bispecific antibodies, developed initially for treating relapsed refractory acute myeloid leukemia. Hemogenyx is advancing this candidate through INDe-enabling studies, highlighting its potential in bone marrow transplant conditioning and pediatric indications.

"We have a chance to make a real difference in the lives of these kids and their families," said Dr Sandler, underlining the company's commitment to pioneering new treatments.

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Quantum Blockchain Technologies PLC chairman and CEO Francesco Gardin speaks to Proactive's Stephen Gunnion about subsidiary Clear Leisure 2017's legal victory in the Venice Court of Appeal.

Gardin provided an overview of the case involving CL17's lawsuit against former directors and auditors of CPM.

While the main defendant is liable for €6.2 million, Gardin said other defendants are liable for various amounts, allowing CL17 to collect from multiple sources if necessary. He also discussed the next steps, including negotiations with the defendants and ongoing efforts to recover the awarded amounts.

In addition to the legal update, Gardin highlighted the progress of Quantum Blockchain's research and development activities.

"Our team of over 20 researchers is making significant strides every day," he stated. "before we release information about the product, we will really want to be 100% sure that it will perform in an operational situation."

For more detailed insights and updates from Quantum Blockchain Technologies, watch the full interview. Don't forget to give this video a like, subscribe to the Proactive channel, and enable notifications for future content.

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