Comedian Dustin Ybarra (@dustin_ybarra) joins Jesse, Andy and Matt to talk about the recent Formula 1 race in Las Vegas, Erdős–Bacon numbers, the first mammal embryos grown in space, space travel's effect on erectile dysfunction, trying to deter orcas with heavy metal, a message laser-beamed from 10 million miles away, the rise of 6G and the ouster and return of OpenAI's Sam Altman after a rumored AGI breakthrough.

Comedian Jenny Zigrino (@jennyzigrino) joins Jesse, Andy and Matt to talk about skunks, the Vegas F1 race, smelling in stereo, the upside of anger in completing tasks, dominant eyes, Iceland volcanos and the ultra-creepy hamster test or sperm penetration.

Comedian Steve Benaquist (@stevebenaquist) joins Andy, Matt and Jesse to talk about Halloween, Unversal Monsters, neck bolts, Frankenstein's Doug, sandbagging, goldbricking, carpetbagging and teetotaling, a radioactive toy from the 1950s, an unfortunate pig heart update, people who can't feel pain, Frozen Dead Guy Days, physics-defying sperm, a wind-powered car that goes faster than the wind, a tiny particle accelerator and Andy's Airbnb.

Comedian Aparna Nancherla (@aparnapkin) joins Matt, Jesse and Andy to talk about her new book Unreliable Narrator, the ubiquity of impostor syndrome in Hollywood, childhood memories of carob, a new insanely hot pepper, roosters recognizing themselves in mirrors, a drunk dude fighting his reflection, and AI besting humans at Street Fighter.

Comedian, musician and now author Dave Hill (@mrdavehill) joins Jesse, Andy and Matt to talk about his lifelong love of hockey, his new book The Awesome Game, bowling lane oil patterns, figuring out how cats purr, bespectacled chickens, and the first-ever fine issued for space junk.

Andy's away, but Matt and Jesse are joined by Kevin Kataoka and returning guest Brian Malow to talk about pseudolegal grifts! Why you shouldn't talk to the police! Scientists who've grown a human embryo!  Brian May side projects! Hedy Lamarr's inventions! Military subterfuge and ghost armies! And sailing a satellite out of orbit!

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Comedian/biomedical engineer Pallavi Gunalan (@PallaviGunalan) joins Matt, Jesse and Andy to talk about her path from science to comedy, working on open-source ventilators, the oldest living skydiver, the oldest surfer, growing human kidneys in pigs, the surprising intelligence of jellyfish and a misread of one of Newton's laws.

Andy's back from Burning Man to give the gang an update on how not big of a deal the rain was and to talk about Jesse's love of the band Ghost, middle-age music obsessions, the viral sensation "Sitting" by Brian Jordan Alvarez, debunking a Da Vinci tree rule (and figuring out what, exactly, bunk is), the greatest-ever opening line of a textbook, the risks of eating a single super-hot chip and how much you'd have to pay Jesse to do it.

Comedian, Kimmel writer and now author Jesse Joyce joins us to talk about his new book about the killer of Lincoln's killer! Plus live brain worms! The Indian moon landing! Unimpressive household robots! And who should go to Mars!

Click here for a free trial of Scribd and read/listen to Jesse's book.

Comedian, actor and host of The John Fugelsang Podcast and SiriusXM's Tell Me Everything John Fugelsang (@JohnFugelsang) joins Jesse, Andy and Matt to talk about Prince's showstopping Beatles solo, reconciling science and the Bible, Russia crashing a lander into the moon, the steampunk LK lunar module, warnings of the submersible implosion, the 1970s SoCal Hurricane Kathleen, the reason it takes a while for a tan to show up and a view of Hurricane Hilary from the ISS.