Comedian DeAnne Smith (@DeAnne_Smith) joins Matt, Andy and Jesse to talk about DeAnne's new special Chiweenie in a Tank Top, getting Canadian citizenship, advances in pig-human transplantation, the possibility of regrowing human teeth, the game Pizza Party and the Radiolab episode about Alpha Gal.

Comedian Jamel Johnson (@NonProfitComic), host of too many podcasts to count, joins Matt, Jesse and Andy to mourn Paul Reubens, discuss Amazing Larry and his deleted scene, the Cabazon dinosaurs, Sonic & Knuckles, Michael Jackson's Sonic connection, how to help striking film and TV workers, a tick bite that can cause a meat allergy, leprosy on the rise in Florida, Mars spinning (slightly) faster, crushing a design contest for kids and connecting old mice to young mice.

American Gladiator Danny Lee "Nitro" Clark joins Andy, Jesse and Matt to talk about the hit Netflix documentary Muscles & Mayhem, how his "raw meat" tryout ad-lib landed him the role of a lifetime, the analogies between management's treatment of the Gladiators and the current WGA/SAG strikes, the odd experience of seeing yourself as an action figure, nostalgia for the monoculture, Nitro's romance with Ellen Degeneres, the role genes play in determining your endurance ability, introducing height classes into basketball, and Tony Vainuku's other Netflix doc about Manti Te'o.

Comedian/writer/director Bethany Dwyer (@BethanyDwyer) returns to the show to talk with Matt, Jesse and Andy about her horror film Grandpa, self-repairing metal, action movie one-liners, why dolphins and orcas won't be returning to land, the resurrection of 46,000-year-old nematodes and the list of human evolution fossils.

Brooks Wheelan (@brookswheelan) returns to the podcast to celebrate 500 episodes of Probably Science and talk about Probarbenheimer, the demise of Summer Country, a new venomous snake, a solar telescope array that cost half as much as White Chicks, unlocking car doors with tennis balls and creating weather forecasts with AI.

Comedian Karl Hess (@karlhess) of the podcast Yelling About Pâté and the live show Amuse Bouche returns to the show to talk with Jesse, Matt and Andy about urban legends, ancient Chinese secrets, a possible bit of alien technology that crashed into the ocean, a Cuban lung cancer treatment, Kyle Kinane getting his van stuck in Joshua Tree, the poop-filled beaches of Texas, an extremely shiny exoplanet, and the handful of companies that control the world's beer.

Dan Schreiber of the podcasts No Such Thing as a Fish and The Cryptid Factor, as well as the new book The Theory of Everything Else, joins Matt and Jesse to talk about Nobelitis, using insects to turn beer waste into beef, an ancient slasher dolphin with weird teeth, using shopping cart sensors to identify stroke risk and Keith Alberstadt's bat attack.

On a very special guest-less episode, Matt, Jesse and Andy talk about the fate of the OceanGate Titan, extreme undersea pressure, the curse of the Titanic, whether the Kursk could have been saved, the slightly dubious age-defying claims of a man who lived underwater for several months, the approval of lab-grown meat, Jesse and Andy's latest video game forays, what kangaroos did before they hopped, the problematic platform of RFK Jr. and Matt and Andy's wallaby encounter.

Comedian John Conroy (@ConroyFTW) joins Jesse, Andy and Matt to talk about Grimace's birthday, driving Ronald McDonald around, finding the building blocks of life on Enceladus, federal capital offenses, frog pants, how many people haven't tried ChatGPT and nanotattoos that don't need batteries or wires.

Comedian Anna Valenzuela (@annavisfunny) joins Matt, Jesse and Andy to talk about her myriad jobs including trolley operator and karate instructor, China's space monkey sex plans, why race car drivers blink at the same point on the track and why Michael Caine never blinks at all.