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Practical Radiation Oncology deputy editor James B. Yu, MD, Columbia University Irvine Center hosts a conversation on ASTRO clinical practice guideline on radiation therapy for Brain Metastases. Eric Chang MD of the Keck School of Medicine of USC and Veronica Chiang, MD, of Yale University School of Medicine discuss the recommendations in the four key areas: what are the indications for radiosurgery alone for brain metastases, what should be done before or after surgical resection of brain metastases, when and how should we do whole brain radiation, and what are the risks of radionecrosis. Two of the guideline authors, Jona A. Hattangadi‐Gluth, MD of the University of California, San Diego and Vinai Gondi, MD of Northwestern Medicine Cancer Center and Proton Center discuss the development process of the guideline and the evidence for the recommendations.