Ryan and Amy Green were facing the unfaceable: their youngest son, Joel was diagnosed with terminal cancer after his first birthday. Producer Sruthi Pinnamaneni tells the story of how Ryan and Amy stumble onto an unlikely way of processing their experience fighting alongside Joel: they decide to turn it into a video game. In the end, they find themselves facing what might be, for a game designer or a parent, the hardest design problem ever.

Correction: In the original audio we stated that the survival rate of childhood AT/RT cancer is 50% over five years. But studies suggest the survival rate is 50% over two years. The audio has been updated to reflect this change.

For an extended version of this story and a bunch more incredible stories, go check out Reply All.

Special thanks to Eilis O’ Neill, Jon Hillman, and Josh Larson. This episode included audio from “Thank You For Playing,” a documentary film about the creation of That Dragon, Cancer by David Osit & Malika Zouhali-Worrall. You can learn more about the film and where you can see it, at thankyouforplayingfilm.com. For more, we suggest reading Wired's "Playing For Time."

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This episode we take a sober look at the throbbing, aching, craving desire states that return people (again and again) to the object of their addiction … and the pills that just might set them free.

Reporter Amy O’Leary was fed up with her ex-boyfriend’s hard-drinking, when she discovered a French doctor’s memoir titled The End of My Addiction.  The fix that he proposed seemed too good to be true.  But her phone call with the doctor left her, and us, even more intrigued. Could this malady – so often seen as moral and spiritual - really be beaten back with a pill?

We talk to addiction researcher Dr. Anna Rose Childress, addiction psychologist Dr. Mark Willenbring, journalist Gabrielle Glaser, The National Institute of Health’s Dr. Nora Volkow, and scores of people dealing with substance abuse as we try to figure out whether we're in the midst of a sea change in how we think about addiction.

Produced by Andy Mills with Simon Adler

If you are someone looking for help with a substance abuse problem and want to find health care services in your area, check out this map from the Substance Abuse and Mental Health Administration.

For more on Dr. Mark Willenbring and the Alltyr Clinic visit their website.

If you’d like to hear more from Nora Volkow you can watch her speech from this summer’s American Psychiatric Association’s annual meeting.

Or watch her and other top addiction researchers at last year’s World Science Fair 

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What happens when you combine an axe-wielding microbiologist and a disease-obsessed historian? A strange brew that's hard to resist, even for a modern day microbe.

In the war on devilish microbes, our weapons are starting to fail us.  The antibiotics we once wielded like miraculous flaming swords seem more like lukewarm butter knives.

But today we follow an odd couple to a storied land of elves and dragons. There, they uncover a 1000-year-old secret that makes us reconsider our most basic assumptions about human progress and wonder: What if the only way forward is backward?

Reported by Latif Nasser. Produced by Matt Kielty and Soren Wheeler.

Special thanks to Steve Diggle, Professor Roberta Frank, Alexandra Reider and Justin Park (our Old English readers), Gene Murrow from Gotham Early Music Scene, Marcia Young for her performance on the medieval harp and Collin Monro of Tadcaster and the rest of the Barony of Iron Bog.

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An update: Peacenik baboons, a man in a dress and cuddly tame foxes. Stories of adaptation, and reframing ideas about normalcy. 3 stories where choice challenges destiny. 

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It would seem that hackers today can do just about anything they want - from turning on the cellphone in your pocket to holding your life's work hostage. Cyber criminals today have more sophisticated tools, have learned to work collaboratively around the world and have found innovative ways to remain deep undercover in the internet's shadows. This episode, we shine a light into those shadows to see the world from the perspectives of both cybercrime victims and perpetrators.

First we meet mother-daughter duo Alina and Inna Simone, who tell us about being held hostage by criminals who have burrowed into their lives from half a world away. Along the way we learn about the legally sticky spot that unwitting accomplices like Will Wheeler find themselves in.

Then reporter and author Joseph Menn tells us about the surprisingly lucrative professional hacker structure in places throughout the former Soviet Union. Finally, the co-creator of one of the most notorious online marketplaces to ever exist speaks to us and NPR cyber-crime expert Dina Temple-Raston about how a young suburban Boy Scout can turn into a world renowned black hat hacker.

Produced by Kelsey Padgett and Andy Mills. 

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In memory of one of our dear friends, a re-release of our last conversation with Dr. Oliver Sacks.  

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As we're busy working on our next episode, with stories inspired by the Periodic Table of Elements, we thought we'd bring you one of its chief inspirations.  As a young boy, neurologist, author and Radiolab favorite Oliver Sacks pored over the pages of the Handbook of Physics and Chemistry, fantasizing about the day that he, like the shy gas Xenon, would find a companion with whom to connect and share. That companion turned out to be the Periodic Table of the Elements itself, a relationship he's never outgrown. He introduces us to the elements that he's known and loved. 

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The definition of life is in flux, complexity is overrated, and humans are shrinking.

Viruses are supposed to be sleek, pared-down, dead-eyed machines. But when one microbiologist stumbled upon a GIANT virus, hundreds of times bigger than any seen before, all that went out the window.  The discovery opened the door not only to a new cast of microscopic characters with names like Mimivirus, Mamavirus, and Megavirus, but also to basic questions: How did we miss these until now? Have they been around since the beginning? What if evolution could go … backwards?

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A donation leads Sarah and Ross Gray to places we rarely get a chance to see. In this surprising journey, they gain a view of science that is redemptive, fussy facts that are tender, and parts of a loved one that add up to something unexpected.

Before he was even born, Sarah and Ross knew that their son Thomas wouldn’t live long. But as they let go of him, they made a decision that reverberated through a world that they never bothered to think about. Years later, after a couple awkward phone calls and an unexpected family road trip, they managed to meet the people and places for whom Thomas’ short life was an altogether different kind of gift.

Since we first aired this segment, some exciting things have happened in the Gray's world. Our producer Tracie Hunte sat down with Sarah Gray to get the low-down on what's new. Check it out here: 

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This is the story of a few documents that tumbled out of the secret archives of the biggest empire the world has ever known, offering a glimpse of histories waiting to be rewritten.

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