Enjoy this Curbsiders classic and stay tuned this Wednesday, August 25, 2021 for a brand new CBC Abnormalities Triple Distilled episode.

Take a deep dive into common CBC abnormalities. We recorded LIVE at joint grand rounds between Walter Reed NMMC and Uniformed Services University with hematologist, Dr. Mary Kwok MD. Topics include: which parts of the complete blood count (CBC) are most important, interpreting the differential, when to order flow cytometry, who needs a hematology consult and simplified approaches to patients with leukocytosis, leukopenia, erythrocytosis and thrombocytopenia.

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Time Stamps*

Time Stamps refer to ad-free version

00:00 Intro; Paul shame’s the audience; Guest bio

03:17 Guest one-liner, book recommendation* –Emperor of All Maladies (book) by Siddhartha Mukherjee, When Breath Becomes Air (book) by Paul Kalanithi; Career advice -set goals for whatever you’re learning.

08:43 Picks of the week: John Wick 3 (film); The Movies That Made Me (podcast) by Joe Dante; The Tim Ferriss Podcast with Julie Rice of Soul Cycle; Infinity Chamber (film) by Travis Milloy

11:50 A case of asymptomatic leukocytosis; Red flags; Repeat the CBC until it’s normal

17:30 The peripheral smear; Leukemoid reaction

20:00 The physical exam; When to send flow cytometry?

22:18 A case of lymphopenia; benign ethnic neutropenia; What to look for in the history

27:10 A case of erythrocytosis; Checking EPO levels; JAK2 mutation; Differential Diagnosis; Therapeutic Phlebotomy; Physical findings of Polycythemia Vera

36:53 A case of thrombocytopenia; Lab workup; Differential diagnosis; Pathophysiology; Culprit meds

45:35 Advice for internists

46:36 Take Home Points

47:46 Dr. Kwok’s disclaimer

48:10 Outro and post credit scene