Sue Yom, our Editor in Chief, leads a discussion of Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials, a critical review from AAPM and NRG Oncology. Guests are first author Dr. Heng Li, Associate Professor in the Department of Radiation Oncology and Molecular Radiation Sciences at Johns Hopkins University and Chief Proton Physicist of the Johns Hopkins National Proton Center, supervising author Dr. Stanley Benedict, Professor and Vice Chair of Clinical Physics in the Department of Radiation Oncology at the University of California Davis, and co-author Dr. Nina Mayr, Professor in the College of Human Medicine at Michigan State University.