Editor-in-Chief Sue Yom hosts Dr. Ralph Ermoian, Associate Professor from the University of Washington and Dr. Kilian Salerno, Associate Research Physician from the National Cancer Institute, our two successive Pediatric/Sarcoma Section Editors who supervised the PEdiatric Normal Tissue Effects in the Clinic (PENTEC) peer review process for our journal. We also welcome two representatives from the PENTEC group, Dr. Louis Constine, Professor of Radiation Oncology and Pediatrics and Vice Chair in Radiation Oncology from the University of Rochester and Dr. Soren Bentzen, Professor and Division Director of Biostatistics and Bioinformatics in Epidemiology and Public Health at the University of Maryland. We discuss several papers from this landmark 12-year effort, including Comparison of Risks of Late Effects from Radiotherapy in Children versus Adults: Insights from the QUANTEC, HyTEC and PENTEC Efforts; Neurocognitive Effects and Necrosis in Childhood Cancer Survivors Treated with Radiotherapy: A PENTEC Comprehensive Review; Risks of Spinal Abnormalities and Growth Impairment After Radiation to the Spine in Childhood Cancer Survivors: A PENTEC Comprehensive Review; and Risk of Subsequent Neoplasms in Childhood Cancer Survivors after Radiation Therapy: A Comprehensive PENTEC Review.