In this episode, hosts Drs. Peter Lu and Jason Silverman talk to Dr. Rima Fawaz about the role of GLP-1 receptor agonists in the treatment of children and adolescents with metabolic dysfunction-associated steatotic liver disease or MASLD (the artist formerly known as non-alcoholic fatty liver disease or NAFLD). We discuss what these medications do, what we know about their positive and negative effects, and how we should be using them based on the current literature. Dr. Fawaz is Medical Director of Pediatric Hepatology and Liver Transplantation at Yale New Haven Children's Hospital and Associate Professor at Yale School of Medicine.

Learning Objectives:

1. Understand the therapeutic and potential adverse effects of GLP-1 receptor agonists.
2. Recognize that the foundation of obesity and MASLD treatment remains lifestyle changes focused on diet and exercise.
3. Recognize the role that GLP-1 receptor agonists will play in our care for children and adolescents with obesity and MASLD.

Links:

Abou Jaoudeh RAR, et al. Pharmacological management of pediatric metabolic dysfunction-associated liver disaese. J Pediatr Gastroenterol Nutr. 2025.

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