We visited Clayton, Missouri for a State of the Science Summit on Hematologic Malignancies with faculty from Washington University School of Medicine in St. Louis and Siteman Cancer Center. The meeting covered novel agents and combinations in chronic lymphocytic leukemia, advances in acute myeloid leukemia, management of newly diagnosed and relapsed/refractory multiple myeloma, progress in myeloproliferative neoplasms, patient selection for Hodgkin lymphoma therapy, and current data with chimeric antigen receptor T-cell therapy.