We recently traveled to Tampa, Florida, for a State of the Science Summit on Gastrointestinal Malignancies. At the meeting, faculty from Moffitt Cancer Center and Mayo Clinic reviewed the latest data in gastrointestinal oncology, covering all aspects of current care, from patient selection to the optimal timing of targeted therapy, immunotherapy, and chemotherapy, in neuroendocrine tumors, hepatocellular carcinoma, pancreatic cancer, gastric and gastroesophageal cancer, and colorectal cancer.