We recently traveled to Philadelphia, Pennsylvania for a State of the Science Summit™ on Hematologic Malignancies. At the meeting, faculty from The University of Pennsylvania discussed updates in multiple myeloma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia, mantle cell lymphoma, and non-Hodgkin lymphoma. Additionally, we heard about emerging treatment options for benign hematologic disorders including severe aplastic anemia, paroxysmal nocturnal hemoglobinuria, and immune thrombocytopenic purpura.