We recently traveled to Miami, Florida for a State of the Science Summit™ on Gastrointestinal Malignancies. At the meeting, faculty from the Florida Society of Clinical Oncology discussed the novel agents that are generating excitement in advanced hepatocellular carcinoma and cholangiocarcinoma and the novel therapies and strategies that are propelling progress in gastric cancer. Moreover, panelists shed light on the use of molecular testing in colorectal cancer and the current and investigational treatment strategies in the relapsed/refractory setting. Other key topics included remaining challenges with staging in pancreatic cancer, unanswered questions in the localized setting, and the benefits of olaparib in the metastatic setting.