Pituitary World News has undertaken an initiative to understand and share the complicated issues related to medication access so patients can join us in advocating for a better system. In that tangle, we find insurance companies, orphan drug manufacturers, specialty pharmacies, pharmacy benefit managers (PBMs), prescribers, and others that add to the costs and complicate access. The issues get even murkier when considering patients on Medicare and Medicaid, their pricing models, and copay requirements. We are committed to understanding the issues from all angles, how they affect pituitary patients' care, and the advocacy effort needed to make it better, lower out-of-pocket costs, and, more significantly, simplify access. Additionally, we aim to understand how prescription drug regulations affect patients and physicians. This is the first in a series of podcasts and articles on the subject.