Welcome to our 61st episode and the beginning of our sixth season! Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recently published clinical trial in The Journal of Clinical Endocrinology & Metabolism that tries to understand the impact of genetics on the benefits of a lifestyle program in reducing the risk of developing type 2 diabetes. Personalized or precision medicine has been a hot topic for several years now, and this podcast has recently reviewed a few studies that fit that description. The authors of this investigation try to answer the question of how we can decide in advance which patients are particularly likely to benefit from a given intervention. Dr. Hendrickson talks with Ashok Balasubramanyam, MD, from Baylor College of Medicine, and guest expert Miriam Udler, MD, PhD, from Massachusetts General Hospital. The article featured this month, by Lankinen et al, was published in the January 2025 issue of JCEM: “Effects of Genetic Risk on Incident Type 2 Diabetes and Glycemia: The T2D-GENE Lifestyle Intervention Trial.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl061 — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent study in The Journal of Clinical Endocrinology & Metabolism that reports on the benefits of older weight-loss medications in a population of women with polycystic ovary syndrome (PCOS). Much of the attention today in obesity medicine focuses on GLP-1 receptor agonists. However, these medications are not treatment options for many of our patients, so we thought this paper asked important questions that we would want to know the answers to. Dr. Hendrickson talks with Na Shen, MD, from the University of California, Los Angeles, and guest expert Stanley G. Korenman, MD, also from UCLA. The article featured this month, by Bandeira Marchesan et al, was first published in JCEM in September 2024: “Topiramate Added to Metformin for Obesity Control in Women With Polycystic Ovary Syndrome.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl060 — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent investigation in The Journal of Clinical Endocrinology & Metabolism that tries to illuminate the relationship between serum testosterone and fractures in men. Ever since the release of the TRAVERSE fracture findings last year, we as endocrinologists have been uncertain in how to think about testosterone and bone health, as that trial made us question what we thought we already knew. So we thought that this article would be an important one to review and are eager to discuss it. Dr. Hendrickson talks with Anna Goldman, MD, from Harvard Medical School and guest expert Peter J. Snyder, MD, from the University of Pennsylvania. The article featured this month, by Grahnemo et al, was first published in JCEM in October 2024: “Associations of Serum Testosterone and SHBG With Incident Fractures in Middle-Aged to Older Men.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl059-testosterone-levels-and-fracture-risk-in-men — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a study in The Journal of Clinical Endocrinology & Metabolism that reports the relationship between body mass index and percent body fat in terms of defining overweight and obesity. He talks with Andrew Kraftson, MD, from the University of Michigan and guest expert Beverly Tchang, MD, from Weill Cornell Medicine in New York City. The article featured this month, by Potter et al, was first published in JCEM in May 2024: “Defining Overweight and Obesity by Percent Body Fat Instead of Body Mass Index.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl058-bmi-vs-percent-body-fat-in-defining-obesity — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a study in The Journal of Clinical Endocrinology & Metabolism that gives insight into how we should wean patients off long-term glucocorticoid use and how successful that typically is. He talks with Salila Kurra, MD, from Columbia University and guest expert Felix Beuschlein, MD, from University Clinic Zurich in Switzerland. The article featured this month, by Arshad et al, was published in the November 2024 issue of JCEM: “A Retrospective Study on Weaning Glucocorticoids and Recovery of the Hypothalamic-Pituitary-Adrenal Axis.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl057-weaning-glucocorticoids-and-hpa-recovery — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in Journal of the Endocrine Society assessing plasma renin in the management of individuals with primary adrenal insufficiency. He talks with Jill Wagoner, MD, from the University of Nebraska and guest expert Irina Bancos, MD, from Mayo Clinic. The article featured this month, by Piazzola et al, was published in the November 2024 issue of JES: “Plasma Renin: A Useful Marker for Mineralocorticoid Adjustment in Patients With Primary Adrenal Insufficiency.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl056-renin-measurements-in-primary-adrenal-insufficiency — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent systematic review and meta-analysis in The Journal of Clinical Endocrinology & Metabolism about the role for T3 replacement in the treatment of people with hypothyroidism. He talks with Andrew Crawford, MD, from Dartmouth-Hitchcock Medical Center and guest expert James Hennessey, MD, from Beth Israel Deaconess Medical Center. The article featured this month, by Esberard de Lima Beltrão et al, was first published online in JCEM in September 2024: “Treatment Preferences in Patients With Hypothyroidism.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl055-t3-replacement-in-the-treatment-of-hypothyroidism — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism providing data in support of metformin being renal protective. He talks with Steven D. Wittlin, MD, from the University of Rochester Medical Center and guest expert Silvio Inzucchi, MD, medical director of the Yale Medicine Diabetes Center. The article featured this month, by Wang et al, was first published online in JCEM in July 2024: “Renal Protective Effect of Metformin in Type 2 Diabetes Patients.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl054-renal-protection-of-metformin — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism about the impact of molecular testing for indeterminate thyroid nodules. He talks with Anupam Kotwal, MD, from the University of Nebraska Medical Center, and guest expert Sarah Mayson, MD, from the University of Colorado School of Medicine. The article featured this month, by Lévesque et al, was first published online in May 2024: “Publicly Funded Molecular Testing of Indeterminate Thyroid Nodules: Canada’s Experience.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl053-the-cost-effectiveness-of-molecular-testing-for-indeterminate-thyroid-nodules — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series

Join host Chase Hendrickson, MD, from Vanderbilt University Medical Center, in a discussion about a recent article in The Journal of Clinical Endocrinology & Metabolism about the benefits of surgical cure of primary hyperparathyroidism in women with osteopenia. He talks with Alyson Myers, MD, from Albert Einsten College of Medicine, and guest expert Natalie Cusano, MD, from the Zucker School of Medicine at Hofstra University and the Lenox Hill Hospital in New York. The article featured this month, by Frey et al, was published in the June 2024 issue of JCEM: “Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia.” Show notes can be found at https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series/efl052-osteopenia-as-a-surgical-indication-in-primary-hyperparathyroidism — podcast home page: https://www.endocrine.org/journals/endocrine-feedback-loop-podcast-series