Sage Life & Biomedical Sciences

The authors preprocess each frame of a video sequence, then analyze the sequence frame by frame using a rotating-circle template with a block-matching algorithm, and estimate the rotation rate of the pigmented cells using a pixel-patch correlation.

Cell-based drug absorption assays are an essential component of ADME/Tox testing for lead compounds. In this report, Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound’s absorption characteristics.

Aptamers are oligonucleotides that can bind to various nonnucleic acid molecular targets in a high affinity and specificity. As an emerging class of therapeutic agents, aptamers offer an unparalleled advantage over other classes of therapeutic agents: the possibility to rationally regulate the therapeutic activity of aptamers.

JALA celebrates part two of its two-part special issue on Robotics in Laboratory Automation by discussing one author's historical perspective on the genesis of today's automated laboratory.

The application of a positive pressure based Serial Sample Loading (SSL) system to load the series of sample plugs into the capillary is demonstrated along with the adaptability of the SSL system to generate sample plugs with a variety of volumes in a predictable manner.

An HTS compatible 3D cell culture platform is generated by chemically “welding” polystyrene scaffolds into standard 2D polystyrene 96-well plates. The variability of scaffolds is minimized by introducing automation into the fabrication process.

In this report, Apparent Permeability (Papp) and Efflux data demonstrate how an automated procedure, when compared to manual processing, provides a method that is less variable and is capable of delivering a more accurate assessment of a compound’s absorption characteristics.