Sage Life & Biomedical Sciences

JALA 19.4 August 2014

A miniaturized array device called Vertical-I with its membrane oriented vertically in reference to the table surface finds a protein synthesis yield 144% higher than that of a horizontal device. Plus, β-glucuronidase reaches the synthesis yield plateau after 2 h versus 4 h. When clogging of membrane pores is confirmed, the Vertical-II is designed to fit into a standard 96-well plate holder, increasing protein expression 406% over the horizontal device and consuming 5 times fewer reagents than a commercial device.

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This podcast features Dr. J. Philip Kaiser discussing his recent paper Putative Mechanisms of Environmental Chemical-Induced Steatosis, published in vol. 31(6) of International Journal of Toxicology.

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TIRS Statistics Editor Richard Zink and fellow Editorial Board member Rick Turner discuss January’s Special Issue on Statistics, and the future of statistics in drug development.

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A discussion with Dr. Anne Rowzee of the Center for Drug Evaluation and Research, US FDA about patient input into the design of studies of medicines for multiple sclerosis.

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From part one of the two-part JALA Special Issue on Advancements in Biomedical Micro/Nano Tools and Technology: three authors talk about metastatic dissemination and spread of malignant circulating tumor cells (CTCs) and how physical enrichment technologies may enable analysis of rare CTC phenotypes that may not be otherwise obtained.

A conversation with Dr. Lode Dewulf and Editor-in-Chief, Dr. Stephen P. Spielberg about Dr. Dewulf's article in Therapeutic Innovation & Regulatory Science, the official journal of the Drug Information Association, addressing therapeutics during pregnancy.

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This review highlights recent advances in multiplexed bioanalyses benefitting from microfluidic integration.

The series of manuscripts in the MMB4 DMS supplemental issue of Int J Toxicol provides a synopsis of the drug development strategy employed for the characterization of MMB4 DMS ranging from the actual manufacture of the test article to preclinical safety and efficacy studies.

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Experiments with holographic polymer-dispersed liquid crystal (H-PDLC) gratings driven by surface acoustic waves (SAWs) exhibit switchable properties: the diffraction of the H-PDLC grating decreases and the transmission increases.

The extraction of specific analytes from biological samples is a ubiquitous process spanning many areas within the life sciences.