Science (Video)

The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]

This presentation will briefly trace 70,000 years of cultural evolution from the ancient crossing from Sunda to Sahul, via the swift continental colonization during the Ice Age, through the severe impacts on survival during the Last Glacial Maximum, and the socio-territorial reconfigurations during Holocene sea-level rise. The Australian Aboriginal world had become characterized by low environmental impact habitation, complex social organization systems anchored within constructed sacred origin histories, the persistence of relatively simple dwelling types situated within complex settlement sociospatial structures, and a high quality of life for most, with institutional dispute resolution mechanisms to contain conflicts. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40162]

The transition from Neolithic villages to early cities marked the greatest social transformation faced by our species before the Industrial Revolution. Our ancestors had to learn how to live in new settlements that had more people, higher densities, and more activities than had been known previously. The new adaptations to urban life involved changes in society and social processes, not just individual learning. Some changes came about through social interactions in a process called energized crowding; these include innovations in housing and the use of space, and the establishment of neighborhoods in cities. Other changes were driven by powerful new institutions, including formal governments and social classes. Do ancient cities—and they ways they responded to shocks—might hold useful insights for the development of urban adaptations to climate change today? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40165]

Oil and gas are the most traded commodities on the planet; they are also the chief causes of the most grievous harm our species has yet faced, the burgeoning climate crisis. Bill McKibben is the Schumann Distinguished Scholar at Middlebury College and a founder of Third Act, which organizes people over the age of 60 to work on climate and racial justice. He examines how the export of hydrocarbons, in particular, has become an enormous threat to efforts to rein in greenhouse gasses. It explores the role that America – the world’s biggest exporter of gas – plays in this ongoing catastrophe. And it looks at the role that non-tradeable commodities – sunshine and wind – play in easing this crisis. Series: "UC Berkeley Graduate Lectures" [Science] [Show ID: 40220]

Humans construct their physical worlds in part by designing and constructing new tools, habitations, and in due course diverse buildings and, in some cases, towns and cities and construct their symbolic worlds by putting words together to tell stories, articulate plans, tell lies, seek truth, and much more. This talk offers hypotheses that address a key question for anthropogeny: How did biological evolution yield humans with the “construction-ready brains” and bodies that made us capable of the cultural evolution that created the diversity of our mental and physical constructs that we know today? Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40161]

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]

This talk provides a deep time perspective for assessing the behavioural implications of the creation of the earliest known structure and the technologies used in its making. Evidence for the earliest structure appears relatively late, about 500,000 years ago in Zambia, and before the evolution of Homo sapiens. The next oldest structures were made by Neanderthals in Europe, 176,000 years ago. The site in Zambia preserves rare evidence for the shaping and fitting together of two tree trunks to make a stable framework. The process of combining parts to make a whole reflects a conceptually new approach to technology, one which remains central to everything we make as humans, including structures. Did the invention of combinatorial technology require the use of language to discuss and evaluate diverse ways to form new constructs and constructions? This question arises from the extended planning and expertise needed in the making of combinatorial tools.    Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40160]

Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]

At a global level, Homo sapiens have reshaped the planet Earth to such an extent that we now talk of a new geological age, the Anthropocene. But each of us shapes our own worlds, physically, symbolically, and in the worlds of imagination. This symposium focuses especially on one form of construction, the construction of buildings, while stressing that such construction is ever shaped by diverse factors from landscape to culture and the construction of history embodied in it - and more. After a brief look at birds building their nests as an example of variation on a species-specific Bauplan, we sample a broad sweep of cultural evolution and niche construction from the earliest stone tools of Neanderthals and Homo sapiens through the Neolithic and the rise of cities to the formal and informal architecture of the present day. Finally, we explore the ways artificial intelligence may further change how humans construct their mental and physical worlds. Series: "CARTA - Center for Academic Research and Training in Anthropogeny" [Humanities] [Science] [Show ID: 40169]