Comedian Tig Notaro, who just released her fifth comedy special, "Hello Again," joins us for a chat about the science of her comedy: telling us how she builds jokes, and of course sharing a bunch of dumb and fabulous jokes. Enjoy! 

Here's our Funniest Joke in the World Episode!! 

Find our transcript here: https://bit.ly/ScienceVsTigNotaro

In this episode, we cover:

(00:00) We're interviewing Tig! 

(01:22) I could be a comedian? 

(02:47) How Tig creates a joke 

(08:59) The element of surprise

(12:27) The world's funniest joke?

(13:55) Tig's favorite jokes

This episode was produced by Wendy Zukerman, with help from Michelle Dang, Rose Rimler and Meryl Horn. We’re edited by Blythe Terrell. Mix and sound design by Bobby Lord. Music written by Bobby Lord and Bumi Hidaka. 

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.

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If you Google "The Funniest Joke in the World," you'll be very disappointed. The internet might serve you something like, "What has many keys but can't open a single lock??” (Answer: A piano). Screw that. That's not funny. Enter Science Vs. We’re going on a romp to find out once and for all: What is the funniest joke in the world. According to science. And for this quest we've interviewed a bunch of amazing comics including Tig Notaro, Adam Conover, Dr Jason Leong, Loni Love, as well as special guest Latif Nasser of Radiolab and, of course, some scientists: Neuroscientist Professor Sophie Scott and Psychologist Professor Richard Wiseman. Which Joke Will Win??? 

Find our transcript here: https://bit.ly/ScienceVsFunniestJoke

In this episode, we cover:

(00:00) The Quest Begins

(08:40) Why laughing matters

(13:13) The scientific search for the world's funniest joke

(17:40) Woof, quack or moo?

(21:33) The comedy K

(26:30) Do different cultures have different senses of humour?

(28:27) The winner!

(32:15) Scientific theories of humour (lol)

(38:28) Why the winning joke isn't funny

(40:26) How do you stop a dog from humping your leg? 

(44:43) Meet the comedy gods

This episode was produced by Wendy Zukerman, with help from Michelle Dang, Joel Werner, Rose Rimler and Meryl Horn. We’re edited by Blythe Terrell. Fact checking by Sarah Baum. Mix and sound design by Bobby Lord. Music written by Peter Leonard, Bumi Hidaka, Emma Munger, So Wylie, and Bobby Lord. Thanks to all the researchers we spoke to including Dr Andrew Farkas, Professor Penny MacDonald, Dr Maggie Prenger and a huge thank you to Professor Chris Westbury for sharing your amazing spreadsheet!! Thanks to all the comedians we interviewed in this episode including Tig Notaro, Adam Conover, Loni Love, Takashi Wakasugi, Urooj Ashfaq, Dr Jason Leong, Penny Greenhalgh and Mohammed Magdi.

Another big thanks to Lindsay Farber, Roland Campos, Lauren LoGiudice, Andrea Jones-Rooy and the other comics at Ha! or Nah!: A Joke Lab; and all the comics that we spoke to and couldn't fit into the episode, we really really appreciate you and your time! Thanks to Ben Milam, the Melbourne International Comedy Festival, Stupid Old Studios, Paige Ransbury, the Zukerman Family and Joseph Lavelle Wilson.

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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[Video available on Spotify] Wendy and emma chamberlain of the Anything Goes podcast sit down for a chat and get deep about “the guru effect,” science garbage on the internet, accusations Wendy’s faced of being a pyromaniac, orgasms and much more.

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Tons of us are feeling run-down and crummy and are wondering: What can we do about it? Well, lots of influencers have an answer: balancing our hormones. These influencers, including some doctors, recommend special supplements, diets, exercises, and prescriptions to tame our cortisol, boost our testosterone, and tackle our estrogen. Are they on to something? We get to the bottom of it with endocrinologists Dr. Deena Adimoolam and Prof. Anne Cappola; and urologist Prof. Mohit Khera. 

Find our transcript here: https://bit.ly/ScienceVsHormoneBalancing

(00:00) Hormones are hot right now 

(02:57) A tale of cortisol and supplements

(14:25) Are we in a testosterone crisis?!

(20:42) Should you boost your T?

(27:35) Is estrogen the enemy?

This episode was produced by Rose Rimler, with help from Wendy Zukerman, Michelle Dang,  and Meryl Horn. We’re edited by Blythe Terrell. Fact checking by Erica Akiko Howard. Mix and sound design by Bobby Lord. Music written by Bobby Lord, Bumi Hidaka, and Peter Leonard. Research help from O. Rose Broderick. Recording help from Alex Stuckey. Thanks to all the researchers we spoke to including Dr. Amit Raval, Dr. Andrea Sansone, Prof. Bob Spencer, Dr. Daniel Rippon, Dr. Emma Adam, Dr. Hannah Troxel, Dr. John Hough, Dr. Jonathan Little, Prof. Paul Cooke, and Prof. Paula Hillard. Special thanks to Joel Werner, the Zukerman Family and Joseph Lavelle Wilson. 

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.

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It’s 1849, and a gruesome murder has just happened at Harvard. As body parts turn up, the science of the day is put to the ultimate test to find out: who committed this brutal killing? Prof. Paul Collins tells us how this morbid mystery unfolds.  

Find our transcript here: https://bit.ly/ScienceVsMurderInTheIvoryTower

In this episode, we cover:

(00:00) The murder that shocked Harvard

(02:35) A very rich man disappears

(06:08) The tea chest of horrors

(07:34) The professor

(09:33) The janitor

(12:00) The case against the professor 

(14:25) The trial

(17:48) 1800s forensics enter the picture

(25:29) The verdict

This episode was produced by Kaitlyn Sawrey with help from Wendy Zukerman, Rose Rimler, Meryl Horn and Odelia Rubin. Editing by Blythe Terrell, with help from Caitlin Kenney. Fact checking by Michelle Harris. Mix and sound design by Emma Munger. Music by Emma Munger and Bobby Lord. A huge thanks to Jessica Murphy and the team at the Harvard University Archives, plus Lars Trembly and Matthew Nelson, Frank Lopez, Joseph Lavelle Wilson and the Zukerman Family.

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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Weed has gone mainstream, and it's been rebranded as a wellness drug that you can customize to fit your needs. Want to feel relaxed? Well, you'll need a kind of pot called Indica. Want to get pepped up? Go for Sativa. But what can weed really do for us? We’re going to pack a bowl full of science facts, sit back, put our feet up and find out: Can cannabis really improve your mental health? Does it matter what strain you take? And how safe is it – can it mess with your memory? To find out, we talk to agricultural scientist Dr. Sean Myles, psychopharmacologist Dr. Amir Englund, and psychologist Dr. Carrie Cuttler. 

Find our transcript here: https://bit.ly/ScienceVsCannabisTranscript 

In this episode, we cover:

(00:00) A New World of Weed

(05:32) Can Different Strains of Weed Do Different Things for You?

(13:18) Can CBD Give You a More Mellow High?

(22:46) Can Weed Help with Anxiety or Depression?

(24:55) What Are The Risks of Using Cannabis?

(35:30) What’s the Safest Way to Use Cannabis?

(38:25) Can Weed Boost Your Creativity?

This episode was produced by Meryl Horn, with help from Wendy Zukerman, Rose Rimler, Michelle Dang, and Joel Werner. We’re edited by Blythe Terrell. Fact checking by Eva Dasher. Mix and sound design by Bobby Lord. Music written by Bobby Lord, Bumi Hidaka and Peter Leonard. Thanks to all the researchers we spoke to including Professor Ryan Vandrey, Professor Christopher Barnes, Dr. Siqi Xue, Professor Susan Tapert, Dr. Michael Dunn, Dr. Linda Parker, Professor Deepak D'Souza, Professor Vikaas Sohal, Professor Loren Frank, and Dr. Ethan Russo. Also thanks to Jill Conforti, the Zukerman Family, Joseph Lavelle Wilson, Bernadette Sciandra, and Chris Suter. 

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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Fasting diets are going bonkers right now — some tech bros are down to one meal a day! And health-fluencers claim that intermittent fasting can help you lose weight, live longer and even fight cancer. But meanwhile, recent headlines are screaming that these diets might actually be dangerous — and linked to death from heart disease. Can science sort this all out?? We speak to nutrition researchers Dr. Krista Varady and Dr. Courtney Peterson, as well as cancer researcher Professor Valter Longo. 

Mental health and disordered eating resources are here: spotify.com/resources 

Find our transcript here: https://bit.ly/ScienceVsFasting

In this episode, we cover:

(00:00) Fasting: the fad and the fears

(03:07) Does fasting help you burn fat?

(07:40) How much weight do people lose with intermittent fasting?

(08:47) Is this just calorie restriction?

(13:17) Can fasting help you live longer?

(19:50) Can fasting fight cancer?

This episode was produced by Kaitlyn Sawrey, Nick DelRose and Wendy Zukerman with help from Michelle Dang, Rose  Rimler, Joel Werner and Meryl Horn. We’re edited by Blythe Terrell, with extra editing help from Caitlin Kenney and Annie-Rose Strasser. Fact checking by Eva Dasher and Michelle Dang. Mix and sound design by Peter Leonard and Bobby Lord. Music by Peter Leonard, Emma Munger, Bumi Hidaka and Bobby Lord. A huge thanks to all the researchers we got in touch with for this episode, including Dr Peter Chisnell, Dr Mikkel Holm Vendelbo, Dr Jiahong Lu, Dr Dorothy Sears, Prof. Mark Mattson, Dr James D Dvorak, Dr Calloway Scott, Professor Richard Billows, Professor Nancy Worman, Dr  Barbara Kowalzig  and the University of Alabama, Birmingham. Also thanks to Kimmie Regler, Helen Zaltman, Frank Lopez, the Zukerman Family, and Joseph Lavelle Wilson. 

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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Dreaming might be the weirdest thing that our brains do. Out of thin air we may see ourselves battling a triceratops, or stressing for an exam that we don't have … so why do we do this?? What is going on in our brains to create these bonkers images? For years, the land of dreams was a place for mystics and philosophers, but with groundbreaking technology, we're getting closer to understanding the science of dreams than ever before. Comedians Toni and Ryan join us for a romp through the bizarre science of dreaming, along with neuroscientist Professor Francesca Siclari and dream/sleep researcher Professor Bob Stickgold.

Find our transcript here: https://bit.ly/ScienceVsDreams

In this episode, we cover:

(00:00) Welcome to the Nodcast

(05:11) How our dreams change all night

(08:50) The myth of REM dreams

(14:30) Why do dreams feel so real? 

(22:02) What are we really dreaming about? 

(30:45) Why do we dream? 

(34:46) Could dreams help us process emotions?

This episode was produced by Wendy Zukerman, with help from Joel Werner, Rose Rimler, Meryl Horn, and Michelle Dang. We’re edited by Blythe Terrell. Fact checking by Erica Akiko Howard. Mix and sound design by Bobby Lord. Music written by Bobby Lord, Bumi Hidaka and Peter Leonard. Thanks to all the researchers we spoke to including Dr Dylan Selterman, Dr Nirit Soffer, Professor Caroline Watt, Pr Pilleriin Sikka, Professor Drew Dawson, Dr Başak Türker, Dr Katja Valli, Dr Delphine Oudiette, Dr Sarah Schoch and Dr Dan Rubin. Also thanks to Lauren Silverman, Stupid Old Studios, Andrew Paquette, the Zukerman Family and Joseph Lavelle Wilson.

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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We looked at this class of weight loss drugs a year ago, and they've only gotten more popular — and more controversial. We’re hearing that these kinds of drugs can be tough on your stomach, and that the weight loss comes with worrisome loss of muscle. We’ve also heard claims that they might increase your risk of suicide. So — should we be freaking out here?? We talk to endocrinologist Dr. Vibha Singhal, neuroscientist Dr. Nora Volkow, and gastroenterologist Dr. Michael Camilleri.  

This episode does deal with depression and suicidal thoughts. Here are some crisis hotlines: 

United States: US National Suicide Prevention Lifeline Dial 988 (Online chat available); US Crisis Text Line Text “HOME” to 741741

Australia: Lifeline 13 11 14 (Online chat available)

Canada: Canadian Association for Suicide Prevention (See link for phone numbers listed by province)

United Kingdom: Samaritans 116 123 (UK and ROI)

Full list of international hotlines here 

Find our transcript here: https://bit.ly/ScienceVsOzempic2Scarier 

Chapters:

In this episode, we cover:

(00:00) What are the fears around these weight loss drugs? 

(04:46) Do these drugs melt your muscles?

(11:49) Do these drugs increase the risk of suicidal thoughts? 

(16:15) Can they really paralyze your stomach?

(30:25) Some good news!

(33:36) How Did You Find the Bezoar?

CREDITS

This episode was produced by Rose Rimler, with help from Wendy Zukerman, Meryl Horn, Michelle Dang, and Joel Werner. We’re edited by Blythe Terrell. Fact checking by Erica Akiko Howard. Recording assistance from Selena Seay-Reynolds. Mix and sound design by Bobby Lord and Peter Leonard. Music written by Bumi Hidaka, Emma Munger, Peter Leonard, So Wylie and Bobby Lord. Thanks to all of the researchers we spoke to for this episode, including Dr. Kristen Beavers, Dr. Ellen Fallows, Dr. Joseph Henson, Dr. Dimitrios Papamargaritis, Prof. Roger McIntyre, Prof. Russ Waitman, Dr. Sahib Khalsa,, Dr. Travis Masterson, and Dr. Etienne Wang. Thanks also to Bryant Smith and Lori Segal. And special thanks to the listeners on these medications who checked back in with us.   

A special thanks to the Zukerman Family and Joseph Lavelle Wilson.

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications.

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We’ve been hunting for the fountain of youth for millennia, but if you go online, it looks like the search is over! So we’re looking at some of the buzziest anti-aging hacks out there: the potential powers of young blood, the latest supplements, and a drug that has some scientists really pumped. We talk to researchers Dr. Jim White, Dr. Melanie McReynolds and Prof. Nir Barzilai. 

Find our transcript here: https://bit.ly/ScienceVsAnti-Aging

In this episode, we cover:

(00:00) The Hunt for the Fountain of Youth

(03:07) Can Young Blood Keep Us Sprightly?

(13:05) Do NAD Boosters Work? 

(21:25) Is Metformin a Game-Changer?

(27:50) How the Nerds Stay Young

This episode was produced by Michelle Dang and Wendy Zukerman, with help from Meryl Horn, Rose Rimler, and Joel Werner. We’re edited by Blythe Terrell. Research help from O. Rose Broderick. Fact checking by Eva Dasher. Mix and sound design by Bobby Lord. Music written by Bumi Hidaka, Emma Munger, Peter Leonard, So Wylie and Bobby Lord. A special thanks to all of the researchers we spoke to for this episode, including Dr. Janet Choi, Dr. Gideon Meyerowitz-Katz, and Dr. Xue Li. A special thanks to the Zukerman Family and Joseph Lavelle Wilson.

Science Vs is a Spotify Studios Original. Listen for free on Spotify or wherever you get your podcasts. Follow us and tap the bell for episode notifications. 

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