Scientists in the field of artificial intelligence (AI) are urging for the responsible and ethical use of protein design tools to prevent misuse as bioweapons. To address these concerns and avoid excessive government regulation, researchers have launched an initiative to promote responsible protein design. The initiative has gained support from scientists who utilize AI in biological design. However, some experts believe that government action and regulations should accompany the voluntary guidance. Reports have highlighted the potential for AI tools to aid in the development of biological weapons, raising fears of creating dangerous toxins or highly contagious viruses. The newly launched initiative calls for self-regulation within the biodesign community and emphasizes the need for enhanced DNA synthesis screening. Governments are also considering biosecurity risks associated with AI, including the possibility of introducing screening for federally funded research. While some hope to avoid government regulation for continued advancement, others believe a combination of self-regulation and government oversight is necessary.