CortexCast - A Neuroscience Podcast

Season 3 Episode 3 | Between Order and Chaos: Exploring the Entropic Brain


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Why do psychedelics, dreams, and mental illnesses feel so different from everyday awareness? We unpack the Entropic Brain Hypothesis and what it tells us about flexibility, rigidity, and the architecture of conscious experience. Consciousness may not be a stable state, but a delicate balance between structure and freedom. In this episode, we explore the Entropic Brain Hypothesis - a framework proposing that the richness of conscious experience depends on how flexible and unpredictable brain activity becomes. Drawing on research into psychedelics, altered states, and psychiatric disorders, we discuss how shifts in brain entropy may underlie creativity, rigidity of thought, and therapeutic change, offering a new lens on the dynamics of the mind.
Reference: Carhart-Harris, R.L. (2018) The entropic brain – revisited, Neuropharmacology, 142, pp. 167–178. https://doi.org/10.1016/j.neuropharm.2018.03.010
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