At the time it was published in the New England Journal of Medicine in 2002, ECOG 1594 was the first study to compare whether any of the three chemotherapy regimens used at the time was superior to cisplatin and paclitaxel in patients with advanced non–small-cell lung cancer. In this episode of Lung Cancer Considered, hosts Dr. Stephen Liu and Dr. Narjust Florez interview the ECOG 1594 clinical trial investigators (Dr. Frances Shepherd, Dr. Alan Sandler, Dr. Chandra Belani, Dr. Corey Langer and Dr. Joan Schiller) to learn just how important, and controversial, this study was.