Published studies, including 2 large network meta-analyses, support the safety and efficacy of misoprostol (PG E1) when used for cervical ripening and labor induction. Based on cumulative data, misoprostol administered vaginally at doses of 50 μg has the highest probability of achieving vaginal delivery within 24 hours. Prostaglandin E2 also has proven efficacy. Plus, we are all aware of the safety and efficacy of mechanical methods of cervical ripening; yes…we know that these options may be used either individually or concomitantly. But what about sequential use? Can cervical balloon be used after misoprostol? Or should it be the other way around? Is there a “best way” to do sequential cervical ripening? This episode topic comes from one of our podcast family members. It's a really good clinical question, and we will dive into the data in this episode. And STAY TUNED IN UNTIL THE END for the real-world clinical implications of the data.