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21. Cannabis for Cancer Symptoms: What the Knox Docs Know

What happens when conventional cancer care fails—or patients choose to bypass it altogether? In this illuminating episode of The High Guide, April Pride sits down with Dr. Janice Knox, an anesthesiologist-turned-endocannabinologist who treats cancer through cannabis-based protocols. Dr. Knox shares compelling case studies, including a baby with glioblastoma and a nurse with stage 4 metastatic cancer, both of whom saw remarkable tumor regression without chemotherapy. Through the lens of the endocannabinoid system, she breaks down what a “cannabis for cancer” regimen actually looks like—including terpenes, lifestyle shifts, and the power of personalized protocols. Whether you’re caregiving or just curious, this episode opens a new frontier in healing.

🔵 Key Takeaways

-The endocannabinoid system (ECS) plays a key role in balancing, repairing, and protecting the body—and cannabis can help restore it.

-Dr. Janice Knox shares real patient stories where cannabis-based protocols led to remission without chemo or radiation.

-Cannabis is most effective when integrated into a full lifestyle protocol—nutrition, sleep, gut health, and stress management matter.

-Each cancer type has a cannabinoid and terpene profile that may support better outcomes. For breast cancer: think CBD and CBG.

-Cannabis can complement or replace conventional treatment—but requires collaboration between oncologists and endocannabinologists.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/cannabis-for-cancer-symptoms

Hosted by April Pride

Sign up for April’s newsletter on Substack at https://aprilpride.substack.com/ or at getsetset.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

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BONUS. Behind the CBD Boom: A 360 Marketing Strategy from Two Women Who’ve Done It

What makes a CBD brand stand out in today’s overcrowded market? In this episode, host April Pride talks with Sophia Trunzo and Lior Root, co-founders of Paradigm Media, about what it really takes to grow and sustain a cannabis or CBD company online. With backgrounds in field marketing, paid media, and affiliate strategy, these women understand how to outmaneuver platform bans, make every touch point count, and turn newsletter clicks into long-term customers. Whether you’re building your first brand or scaling an existing one, this episode breaks down their 360 approach to customer acquisition—complete with content campaigns, influencer strategy, and a pre-launch discovery phase that turns marketing guesswork into real growth.

🔵 Key Takeaways

-Paradigm’s 360 strategy includes paid media, affiliates, email, content, and social—all integrated for max impact.

-A successful CBD marketing strategy today requires 10–25+ customer touch points—double that of most industries.

-Email marketing is still queen: up to 60% of CBD brand revenue can come from your list.

-The first 30 days are for testing: a discovery phase helps align your actual audience with your ideal one.

-One-stop shops work: From ads to newsletters to landing pages, Paradigm handles it all so founders can focus on product.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/360-cbd-marketing-strategy

Hosted by April Pride

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20. How Women in Cannabis Are Disrupting the Industry from the Inside Out

What happens when women lead in cannabis? In this episode of The High Guide, April Pride brings together three powerful founders—Raeven Duckett (JOHNNIE), Valerie Sakota (Barbari), and Solonje Burnett (Humble Bloom)—to talk about how they’re shaping the cannabis industry from within. From the legacy market to CBD beauty, these women are redefining what success looks like through collaboration, creativity, and capital. Expect candid conversations on culture, representation, and why “pink and shrink” branding doesn’t work. Whether you’re in the industry or just weed-curious, this one is a blueprint for doing business differently.

🔵 Key Takeaways

-The “legacy market” still dominates cannabis sales

-Female-led brands like Barbari and Frigg are creating low-dose, stress-supportive products that reflect real life—not wellness clichés.

-Capital is still the biggest barrier. Black women are 100x less likely to raise funding than white women in cannabis.

-Collaboration over competition: these founders are modeling a future where shared resources build equity and impact.

-The East Coast is rising, but long-time New York activists risk being pushed out unless we fund them too.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/women-in-cannabis-entrepreneurship

Hosted by April Pride

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19. Is Weed a Psychedelic? Exploring Cannabis’s Trippy Side

Can weed make you trip like acid or mushrooms? In this week’s episode of The High Guide, April Pride unpacks the surprisingly psychedelic effects of cannabis—especially in potent doses. From the science of THC and the default mode network to the mysterious powers of new cannabinoids like THCP, this episode offers a fresh look at how weed can shift your sense of self, time, and the world around you. Plus, hear what happens when you mix cannabis with classic psychedelics like LSD or psilocybin—and why some folks swear it’s euphoric while others spiral into anxiety. If you’ve ever wondered whether weed is a psychedelic or how crossfading really works, this episode delivers clarity, curiosity, and caution.

🔵 Key Takeaways

-THC impacts the same brain receptors as classic psychedelics—just with shorter, subtler effects.

-High doses of potent weed can suppress the default mode network, producing psychedelic-like shifts in perception.

-Combining cannabis with LSD or mushrooms intensifies the trip for some, while others report increased anxiety.

-THCP is a new, hyper-potent cannabinoid that may explain wildly different high experiences.

-Mixing psychedelics should be done mindfully—especially for newer users.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/is-cannabis-a-psychedelic

Hosted by April Pride

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18. Bad Edible Trips & Better Dosing: A Guide for Women Curious About Cannabis

What happens when the edible hits—and you didn’t know it was infused? In this episode of The High Guide, host April Pride brings together three cannabis industry leaders to share their stories and solutions around cannabis edible dosage. Kimberly Dillon recalls a freeway moment gone wrong, Lisa Snyder speaks to ethical sharing, and Devika Maskey reminds us of the importance of clear communication. You’ll walk away with smart, safe approaches to avoid overmedicating, especially in mixed company. This one’s for the women who want to try cannabis edibles again—but better.

🔵 Key Takeaways

-Bad edible experiences usually stem from poor labeling or confusion around THC dosage.

-Start low: 2–5mg is plenty if you’re new to cannabis.

-Always ask if an edible is infused—especially at events or social gatherings.

-Clear labeling and ethical sharing practices help prevent accidental overconsumption.

-Even a “bad trip” can offer insight, if you know how to reflect on it.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/cannabis-edible-dosage-tips-women

Hosted by April Pride

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17. What it Means to Be Cali Sober: Psilocybin Microdosing Dosage

How much is too much? How little is too little? In this episode of The High Guide, April Pride and guest Michelle Lhooq dig deep into the elusive art of psilocybin microdosing—why it matters, how to do it, and what not to do. Drawing from personal experience and global conversations, they cover everything from LSD tinctures to Beyoncé-induced weeping, offering science-backed insight and real-world wisdom for those navigating the Cali Sober lifestyle. Whether you're curious about your first 0.2g dose or recalibrating after a 3.5g hero’s journey, this one’s for you.

🔵 Key Takeaways

-A microdose is typically between 0.1–0.5g of psilocybin—well below a “heroic” 3.5g dose.

-Always start slow, especially in social settings. You can always take more—but not less.

-Set (mindset) and setting (environment) are just as important as dose for a smooth experience.

-Tinctures offer more accurate, fast-acting dosing than chocolates or capsules.

-Guidance from experienced peers or a sober trip-sitter can transform your first experience.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/psilocybin-microdosing-dosage-tips

Hosted by April Pride

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16. What It Means to Be Cali Sober: Michelle Lhooq on Redefining Sobriety

What happens when you quit everything except cannabis and psychedelics? In this episode of The High Guide, April Pride speaks with journalist Michelle Lhooq, who coined the now-mainstream term “Cali sober.” Together, they unpack how cannabis and psychedelics became Michelle’s tools for recovery, self-regulation, and creative reconnection. From New York party girl burnout to desert mushroom ceremonies, Michelle shares how this drug diet reset her body, mind, and spirit—and why this lifestyle resonates especially with high-functioning, high-strung women navigating modern sobriety. Tune in to explore why sobriety isn’t a one-size-fits-all journey, and how women are rewriting the rules.

🔵 Key Takeaways

-“Cali sober” means abstaining from alcohol and hard drugs while using cannabis and psychedelics intentionally.

-Michelle Lhooq coined the term after her personal shift from NYC nightlife to a slower California pace.

-The viral Vice essay that introduced the world to this new sobriety sparked wide media interest and brand adoption.

-Cali sober isn’t a rigid protocol—it’s a flexible framework for redefining wellness and substance use.

-BIPOC women, especially Asian women, often face stigma around drug use; Michelle’s story challenges that narrative

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/cali-sober-lifestyle-explained

Hosted by April Pride

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15. Can You Fly with Weed? Real Talk on Traveling with Cannabis

Whether you're road-tripping to Oregon or flying back from Hawaii, traveling with cannabis is a high-stakes dance between freedom and federal law. This week on The High Guide, April Pride gathers three cannabis-savvy women—Jackie Bryant, Veronica Castillo, and Amanda Reiman—for an unfiltered conversation on what it really means to pack weed, privilege, and risk into your travel plans. Expect raw insights, hilarious hacks (hello, sex toy stash), and reminders that not all travelers carry the same risks. You’ll learn what tools to pack, how to mask the smell, and why a chillum might just be your best friend on the go.

🔵 Key Takeaways

-TSA isn’t actively looking for cannabis—but if they find it, they will confiscate it.

-A smell-proof stash bag is a must. So is repackaging your weed to avoid obvious THC branding.

-Risk tolerance depends on your identity: BIPOC travelers face higher legal stakes.

-Pre-rolls, mini joints, and chillums are ideal for discreet and efficient on-the-go use.

-Clean your pipe or pack it with your dirty laundry—it’s all about plausible deniability.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/tips-for-traveling-with-cannabis

Hosted by April Pride

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14. Inside Cannabis Tourism in California: A Guide to the Emerald Triangle

What happens when you pair Northern California's cannabis heritage with immersive travel? In this episode of The High Guide, host April Pride uncovers the heart of cannabis tourism in California through firsthand experiences in the Emerald Triangle—Humboldt, Mendocino, and Trinity counties. Guests Jackie Bryant, Amanda Reiman, and Veronica Castillo reveal how weed retreats, glamping stays, and DIY adventures are rewriting what it means to “get high.” From the legendary terroir of NorCal bud to honoring the farmers behind the movement, this episode is part travelogue, part pilgrimage. You’ll hear what makes visiting the source of your flower not just novel—but transformative.

🔵 Key Takeaways

-Amsterdam may be out, but California’s cannabis tourism scene is in—and thriving across NorCal.

-The Emerald Triangle offers immersive “weed and…” experiences: hiking, kayaking, history tours, and more.

-Cannabis terroir—like wine—is real. The soil, culture, and climate of the Triangle create distinctive flower.

-Small farms like Sol Spirit Retreats and Booney Acres welcome visitors for glamping and grow education.

-Cannabis travel is also cultural travel: honoring the pioneers and resistance that made legal weed possible.

Learn more about this episode, including guests and resources on substack:https://aprilpride.substack.com/p/cannabis-tourism-in-californias-emerald-triangle

Hosted by April Pride

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