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Practical Radiation Oncology executive editor Sanford Meeks, PhD, hosts a conversation on the use of single-isocenter radiosurgery for multiple metastases. Dr. Meeks is joined by Richard Popple, PhD and John Fiveash, MD from the University of Alabama at Birmingham, as well as Stephen Tenn, PhD from the University of California, Los Angeles and Catherine Mercado, MD, from Orlando Health Cancer Institute. Dr. Meeks and guests discuss the changes in radiosurgery technology, features and differences of different radiosurgery systems, treatment planning procedures, and the clinical considerations when adopting these modalities.