In this episode of SurgOnc Today, we will discuss a few of the practice changing trials presented at the American Society of Clinical Oncology annual meeting this past June. The episode is moderated by Dr. Kelly Hewitt and offers insightful discussion by leaders in medical oncology, including Dr. Jo Chien, Dr. Laura Kennedy and Dr. William Gradishar. Highlights include discussion of results from COMPASS Her2, SERENA-6 and the current state and utility of circulating tumor DNA in patients with early-stage breast cancer.