In this episode of SurgOnc Today, SSO Peritoneal Surface Malignancy Disease Site Working Group members Dr. Alissa Greenbaum and Dr. Omar Llaguna moderate a discussion with Dr. Maheswari Senthil of UC Irvine and Dr. Richard Alexander of the Rutgers Cancer Institute of New Jersey to dive deep into the history of the development of regional therapies such as HIPEC and PIPAC in the United States. The expert discussants answer tough questions regarding the ethical considerations of modern clinical trials and the implementation of experimental therapies into practice.