In this episode of SurgOnc Today, Dr. Miral Grandhi of Rutgers University and Dr. Neha Lad of Mount Sinai Medical Center—both members of the HPB Disease Site Working Group—provide a curated summary of the most impactful hepato-pancreato-biliary malignancy papers presented at the Society of Surgical Oncology's 2025 Annual Meeting in Tampa, Florida. The discussion is moderated by Dr. Patricio Polanco of UT Southwestern Medical Center, who also serves as Vice Chair of the HPB Disease Site Working Group.