Nitrogen is a reality of growing plants, and must be supplied to maximize crop yields.  At the same time our atmosphere is >70% nitrogen that is not usable by plants in its atmospheric form.  Humans have devised processes to “fix” nitrogen into plant usable forms, but they require energy and the products need to be transported, both leading to a substantial carbon footprint.  A number of microbes naturally fix nitrogen, yet do not form good associations with all plants.  Joyn Bio is a collaborative effort by a number of companies in chemistry and synthetic biology. Their CEO Dr. Michael Mille talks about efforts to engineer microbes that can form tight associations with crop plants and fix the nitrogen they need.  These strategies seek to lower the carbon footprint of farming, at the same time limiting nitrogen pollution by producing it directly in association with the plant that needs it.

The JoynBio website
Follow Joyn Bio on Twitter at @JoynBio

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The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Dr. David Zaruk has become the foremost authority on the questionable practices within the IARC and their decision-making process.  Over the last several years he has taken a key point position in interpreting the IARC’s 2015 decision and the political landscape around the agricultural chemical glyphosate.  While controversy swirls, he brings it back to reality with deep dissections of the politics involved in the IARC guidance and other regulatory decisions. He has paid a personal and professional price for telling the truth. He is undoubtedly the leader in communicating the facts about the activist assault on science, reason, and a low-toxicity agricultural chemical.

Dr. Zaruk’s website.
Follow Dr. Zaruk on Twitter:  @zaruk

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Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

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Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
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The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

The tiny mosquito is a nuisance in the industrialized world, yet around the world it is a ruthless killer, spreading blood-borne diseases that bring about pain and suffering, particularly in developing nations.  In many regions these are invasive species with little to no ecological role. For years scientists have used “sterile insect technique” to control them, a process that treats sexually compatible insects with radiation, rendering them infertile.  The low-fertility insects are released into the wild and crash problematic populations. The Oxitec company has a genetic solution.  Mosquitoes have been genetically engineered to contain a lethal gene that can be turned off in the laboratory with a simple chemical.  Upon release, these mosquitoes breed against target populations, spreading the lethal gene, and leaving the next generation inviable.  The process creates a reproductive dead end.  While amazingly successful, these trials have suffered from a lack of public acceptance.  This week an article in Scientific Reports from a credible lab introduced language that bred fear, uncertainty and doubt in the Oxitec approach.  This unwarranted speculation was then amplified and exaggerated by the credulous anti-biotech media, further eroding public perception.  In this episode I spoke with Dr. Kelly Matsen, Research and Development and Operations lead at Oxitech.  She described the experiments in question, the actual results, the published paper, and how Oxitech’s technology actually has worked in field releases.

The Oxitec Website
Follow Oxitec on Twitter, @Oxitec
Link to the EPA Public Comment Period on Mosquito Release

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Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Dr. Elisabeth Bik is a hero. Classically trained with plenty of lab-bench expertise, today she patrols the best scientific literature in search for plagiarism and image manipulation.  Her expert eye identifies manipulated images in our best scientific publications, including the revered science weekly journals that present allegedly breakthrough work. Dr. Bik talks about her path to become a publication sleuth, a high-resolution machine with an eye for things that just don’t look right. She talks about her work, its repercussions and how pervasive plagiarism and image manipulation are in contemporary science.

Please follow her on Twitter.  @MicrobiomDigest
And her blog: Microbiome Digest

# COLABRA
Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

While HIV incidence has remained stable in the industrialized world, the virus is still transmitted in the Developing World.  The development of methods of prophylaxis are critical to disease containment, yet moving products into affected areas is not practical or affordable.  Dr. Evangelia Vamvaka was part of a team that placed anti-HIV proteins into rice.  The rice produced a transgenic protein that inhibited the virus, and did so with great efficacy in the presence of other compounds from the plant.  The rice can be ground to a powder and potentially be used as an HIV preventative wherever rice is grown. Co-hosted by Lethbridge Canada high school student Michelle Wu.

The original paper in PNAS
Follow Dr. Vamvaka on Twitter: @VamvakaEv

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Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Australia has welcomed the use of genetically engineered crops, and farmers have found particular benefit from broad acre canola and cotton cultivation. However, the benefits were not realized by some states because of local moratoriums imposed by state governments. Farmers in South Australia grow wheat, canola and pulses, along with wine grapes, olives and other horticultural crops.  They would like the option to grow GE canola, as it may offer some benefits. More importantly, new technologies in gene editing may permit rapid response to new threats as well as tackle current issues in drought, frost, and pathogens. Fortunately, a science-minded change in government has led to discussion of removing the ban.  I speak with four agricultural leaders from the Grain Producers SA, a non-profit organization coordinating grower advocacy and communications. With Tanya Morgan, Adrian McCabe (@AdrianMcCabe6), Wade Dabinette and Dion Woolford (@rudigermaxpower).

Twitter:  @GrainProducerSA
Website:  Grain Producers SA

# COLABRA
Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Genetically engineered microbes commonly manufacture our vitamins and amino acid supplements, but can they be supplements themselves?  Zbiotics has developed genetically engineered bacteria that may help to metabolize the residues of alcohol consumption, altering the accumulation of the compounds that lead to next-day malaise. These microbes are consumed as a pro-biotic, fortifying the digestive system with a means to break down deleterious metabolites.  Today’s podcast covers the technology with Dr. Zack Abbott from Zbiotics, including a discussion of how a “proudly GMO” product resonates with consumers.

Zbiotics LInks:
https://www.instagram.com/zbiotics/
https://www.facebook.com/ZBiotics/
https://twitter.com/ZBioticsCompany

# COLABRA
Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

Robert Saik is an agronomist and entrepreneur with a lifetime of experience in farming.   For years he has been a leading advocate for farmers, and a passionate voice promoting the newest technologies, whether they are genetic or engineering marvels on the farm.  The 200th episode of the Talking Biotech Podcast aptly hosts Rob and the introduction of is new book, Farming 5.0, How We Feed the Future.  Rob discusses the five waves of agricultural history and speaks to their convergence in the modern farm. It is an accessible and important text that helps everyone understand the modern tenor of food and farming.
 
Food 5.0 on Amazon
Follow Rob on Twitter   @RSaik

Thanks to Sci Babe Yvette D’Entremont and Vern Blazek for flexing their thespian muscles in the voice over! 

# COLABRA
Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.

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Sickle cell disease is an inherited condition that predominantly affects people of African descent. The disease results in chronic pain and early death, and is caused by a misfolding of oxygen-toting hemoglobin, a central protein in red blood cells.  Vertex Pharmaceuticals and the CRISPR Therapeutics companies have combined to test a potential therapy.  A patients stem cells are gene edited using CRISPR/Cas9 so that they stop producing adult mutant hemoglobin, and produce a fetal version instead.  The engineered stem cells are returned to the patient, who then manufactures fetal hemoglobin in their own blood cells, potentially curing the disease. Clinical trials have just begun.  Dr. Brenda Eustace, Director of Discovery Research, takes us through the problem, its effects and the Vertex solution that could bring needed relief to millions worldwide.
Website:  VRTX.com
Twitter:  @VertexPharma

Products move from producer to consumer through complicated networks called supply chains.  These routes of custody involve many people and organizations, and oftentimes cross international borders.  All of these product touch-points are opportunity for contamination or willful adulteration of the product.  High value products like authentic high-end wine, honey or olive oil can be diluted with lesser value amendments, which misleads the consumer and can introduce food safety issues.  Carverr Inc has a solution.  Today’s podcast speaks with Dr. Ellen Jorgensen and Vishall Bhuyan, the co-founders of the company. They use a signature blend of probiotics in the products that can be detected with a simple assay.  This specific signature beacons the presence of adulteration and ensures fidelity and transparency throughout the supply chain, ensuring customers are receiving exactly what they purchased.

Follow Carverr on Twitter:  @CarverLabs
Carverr Inc Website:  www.carverr.com

# COLABRA
Talking Biotech is brought to you by Colabra – an R&D platform that brings your lab’s world-changing research together in one shared space. Learn more at https://www.colabra.app/

# TALKING BIOTECH
Twitter: https://twitter.com/talkingbiotech
Website: https://www.colabra.app/podcasts/talking-biotech/
Instagram: https://www.instagram.com/colabrahq

The Talking Biotech podcast is distinct from Dr. Kevin Folta's teaching and research roles at the University of Florida. The views expressed on the show are those of Dr. Folta and his guests, and do not reflect the opinions of the university or Colabra.