Alnylam Pharmaceuticals has pioneered RNA interference therapeutics, or RNAi. This groundbreaking technology has increased the company’s success rates of bringing medicines through the clinical pipeline—leading to the approval and launch of six new medicines in just six years. Their CEO Dr. Yvonne Greenstreet spoke with Jerry Lee, head of biopharma banking in the global healthcare group, about the applications of Alnylam’s Nobel Prize-winning RNAi technology, her vision for the future of biotech, and the importance of a patient-focused and teamwork-oriented culture. Dr. Greenstreet also discussed her career journey and leadership philosophy —as one of the only women of color leading a major pharmaceutical company.

This episode was recorded on April 23, 2025.

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How can big data reveal the drivers of economic opportunity? Raj Chetty, the William A. Ackman Professor of Economics at Harvard University and director of Opportunity Insights, discusses what can be done to foster upward mobility, the factors that impact a child's chances of success, and the innovative solutions being developed to bridge the opportunity gap. He spoke with Goldman Sachs’ Greg Shell, partner and head of the Inclusive Growth strategy within Asset & Wealth Management, in this Talks at GS. 

This Talks was recorded on March 12, 2025.

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From being the first non-founding employee of Skype to co-founding international money transfer platform Wise, Taavet Hinrikus has been at the center of Europe’s technology ecosystem. Today at early-stage VC Plural, he focuses on funding European tech startups and supporting the next generation of founders. He spoke about the impacts of early exits, the importance of backing mission-driven entrepreneurs, and his optimism for Europe’s tech landscape with Clif Marriott, Goldman Sachs co-head of the Technology, Media and Telecommunications Group in EMEA. The conversation was filmed at Goldman Sachs’ Disruptive Technology Symposium in London on March 5, 2025.

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Adena Friedman, Chair and CEO of Nasdaq, has expanded Nasdaq from an exchange operator to a global technology and insights platform. She spoke with Goldman Sachs COO and President John Waldron about how Nasdaq is utilizing AI and cloud technology to drive financial innovation, as well as the company’s vision for making public markets more attractive to companies.

This episode was recorded on April 7, 2025.

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OpenAI is at the forefront of the generative AI revolution.

How did it get there, and what is the company doing to stay ahead of its

competitors? Sarah Friar, chief financial officer of OpenAI and former head of

technology equity research at Goldman Sachs, discusses the path to artificial

general intelligence and the importance of capital in the AI race with Dan

Dees, Goldman Sachs Global Banking & Markets co-head. The conversation was

filmed at Goldman Sachs’ Disruptive Tech Summit in London on March 5, 2025.

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Yasmin Green is the CEO of Jigsaw, the unit at Google that builds technology aimed at protecting open societies. She joined Goldman Sachs’ Sharmin Mossavar-Rahmani, head of the Investment Strategy Group and chief investment officer of Wealth Management, to share Jigsaw’s mission and the innovative tools they are building to harness AI for constructive communication.

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Richard Buery is the CEO of Robin Hood, New York City’s largest poverty-fighting philanthropy. Since its founding in 1988, Robin Hood has invested more than $3 billion dollars in the fight against poverty. In this Talks at GS with Tony Pasquariello, global head of hedge fund coverage for Global Banking & Markets, co-head of One Goldman Sachs, and Robin Hood board member, Buery discusses the critical role of early childhood education, mental health, and public-private partnerships in creating lasting change, and how innovative approaches, including AI, are reshaping anti-poverty efforts.

This episode was recorded on February 26, 2025.

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Carl Nassib spent seven years in the NFL as a linebacker for the Cleveland Browns, Tampa Bay Buccaneers, and Las Vegas Raiders. In this Talks conversation with Susie Scher, senior advisor in the Financing Group within Goldman Sachs Global Banking & Markets, Nassib discusses his journey from Penn State walk-on to captain of the Buccs. After leaving the NFL, Nassib founded Rayze, an app that connects non-profits to volunteers and donors. He explains his vision for modernizing the philanthropy industry, and also discusses the response he received when he made history as the first openly gay active player in the NFL, and his recent work with The Trevor Project, an organization focused on supporting LGBTQ+ youth.

This episode was recorded on November 19, 2024.

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Blackstone is the world’s largest alternative asset manager, with more than $1.1 trillion in assets under management. Blackstone President & COO Jonathan Gray says recognizing patterns and having a contrarian view are key to excess returns, and the reason why Blackstone has been able to grow so rapidly. In this Goldman Sachs Talks, Gray sat down with John Waldron, President & COO of Goldman Sachs, to discuss positive signs in the real estate market, why company culture is important, and lessons from his over 30 years at Blackstone. This episode was recorded on October 28, 2024.

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In this episode of Talks at GS, John F. Crowley, chairman and CEO of Amicus Therapeutics discusses his leadership at Amicus Therapeutics, his efforts to develop cutting-edge treatments for rare diseases and disorders, and his perspective as a biotech innovator on the global response to the pandemic.

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