▶ Explore this week’s Tape — live, sortable, drill-down →
A note from the desk: this week’s update is landing a few days late. We hit a technical problem over the weekend that took our production pipeline down. Everything below is as of Friday’s close, August 7. We’re back on the normal cadence next week. ## The Public Market Just Quoted a Price on a Drug Pipeline. The Price Was Zero.
Eighteen billion dollars of biotech changed hands inside seventy-two hours this week, and not one dollar of it was priced by the tape. That is the part worth sitting with. Not the premiums, not the CEO change, not the guidance cut. The fact that when a listed market and a private buyer looked at the same molecules on the same Monday, they came back with numbers that do not live in the same decade.
The cleanest evidence is an instrument almost nobody will look at. Curium is paying a hundred-two-fifty a share in cash for Lantheus at closing, plus up to twelve dollars a share in contingent value rights tied to clinical milestones, with the deal closing in the first half of 2027.¹ Lantheus finished the week around a hundred and one.² Read that as the market does: the cash is money-good, and the twelve dollars of clinical optionality is worth approximately nothing.
Approximately nothing.
That is not a Lantheus fact. It is a quoted, tradeable, sector-wide statement about what the public market will pay for radiopharmaceutical milestones it has not yet seen work, and the answer is that it will not pay. Every discounted-cash-flow argument about pipeline value in this space now has a live market print arguing against it, and the print says zero.
Meanwhile the buyers on the other side of that refusal are underwriting the exact same molecules at a discount rate the tape will not touch. Vertex beat the quarter, raised the year to roughly thirteen billion, and wrote a ten-billion-dollar cash check for Crinetics at eighty-five a share in the same week.³⁴⁵ It can do that because a franchise throwing off close to four billion of trailing free cash flow, marked in the Cash Flow Memo around thirty times, funds a decade-long option without going near the debt line.⁶⁷ Curium is private capital reaching the same conclusion through a different funding stack. Both transacted above where the listed market had the asset marked. The cashflow read is in Marcus’s column below; short version, Lantheus screens like a cash machine and now trades like a legal document.
And then BioNTech, which is the one that ratifies all of it. Seven times trailing free cash flow, a fourteen percent yield, a market that has effectively stopped underwriting a future at all.⁸⁹ Management’s answer was not to argue. It halved the revenue guide, replaced the co-founder in the CEO seat, said it would close manufacturing sites affecting up to eighteen hundred and sixty jobs, and authorized a billion-dollar buyback.¹⁰¹¹¹² That is a management team agreeing, in cash, with the tape’s refusal to fund its own pipeline.
Here is the second-order effect nobody put a number on this week. Every one of these transactions moves the option value of a drug pipeline off a public balance sheet and onto a private or strategic one, at the precise moment the public market has declared that optionality worthless. Public shareholders get the cash and forfeit the decade. That is not a premium — it is a settlement. Crinetics holders get eighty-five dollars today; Vertex gets whatever those molecules are in 2034. Lantheus holders get a hundred-two-fifty and a lottery ticket the market has already voided. The premium is the consolation prize for handing over the part that compounds.
What changes the read. Watch the contingent value right itself. It is a listed instrument that will trade between now and the close in the first half of 2027, and it is the only continuous public quote on radiopharmaceutical milestone risk anyone will get. If it develops a real bid, the public market is re-underwriting clinical optionality and this discount closes. If it sits at nothing through the close, the price-setting has moved permanently off the tape, and the next listed rare-disease or radiopharma name to go strategic or private goes at a premium the screens never marked. The other test is BioNTech’s oncology data, which is the only thing that separates a rational retreat at seven times from a market that got it wrong.
Wall Street’s consensus on biotech M&A: a premium is a win for shareholders. Ten billion in cash and a contingent value right nobody will bid for suggests the premium is what you get paid to stop owning the decade.
The Tape — W2632
Universe of 94 cashflow-memo names, snap dates 2026-07-31 → 2026-08-07. Composite is rank-sum percentile of FCF Yield + NTM Revenue Growth (higher = better balance). Banks and finance-book names shown separately.
Telltales Yield — Top 10
From the Cashflow Desk — Marcus Graham
Lantheus ranks in the table above on cash flows that stopped setting its price this week. The composite reads it as a balanced cash generator, 8.2% FCF yield, top-five in the universe, and none of that is what clears the stock now. It is a legal document trading against $102.50 of cash at closing plus up to $12 a share in contingent value rights, and the tape is marking that $12 at approximately nothing. That is not laziness. Radiopharmaceutical milestones are clinical, not commercial, and the public market has never priced that risk well in either direction. The test between now and the first-half-2027 close is whether the CVR develops a real bid. A bid means someone is re-underwriting milestones the seller could not prove standing on its own.
Telltales Yield — Bottom 10
This Week’s Reporters
Sector Medians
Debt / FCF Watch (highest leverage on TTM FCF)
Weekly Price Movement
Top 5 (week-over-week price)
Bottom 5 (week-over-week price)
Banks (shown separately — FCF metric not meaningful)
Finance-book — FCF not comparable
Customer-float / captive-finance / reserve businesses (IBKR broker float, KMX CarMax Auto Finance, PYPL customer funds, CRCL stablecoin reserves). The memo’s operating-FCF method overstates their FCF, so they are held off the ranked leaderboard pending the P&L-waterfall rebuild.
Data Gaps
85 of 92 ranked-eligible names ranked. 7 dropped for missing FCF yield or NTM revenue growth; 7 shown separately (banks + finance-book, FCF not comparable).
Source: cashflow-memo master_2026-08-07.csv. NTM growth from analyst-estimates consensus. Composite is a percentile rank, not a recommendation.
The Issue — This Week's Brief
The Cashflow Memo
Weekend Update - W2632
Why a Q2 beat bought nothing this week, and $18 billion of biotech changed hands
The Telltales Weekend Update. Ava Cabot and analyst Marcus Graham walk through what happened this week — and what’s coming next — across the companies in the Cash Flow Memo. About 14 minutes. No filler.
Download the memo at telltales.us. Hunt, Jason, and Mike are back Wednesday on episode E2633.
Chapter markers
* Time | Segment
* 0:00 | Cold open — a good quarter bought nothing
* 0:45 | Theme — the quarter is a receipt (AMD, CVS, Celsius)
* 4:45 | Deep dive — page 15: Vertex, Lantheus, BioNTech
* 8:45 | Rapid fire — ConocoPhillips, Harrow, and the forward calendar
* 11:45 | Close, Consensus Watch, and the Wednesday tease
* 12:40 | Closing disclaimer
Full transcript
Cold open
Ava: A good quarter bought you nothing this week. The companies that beat got sold. The one that missed got an activist who wants the CEO’s job. And the biggest checks anyone wrote were for assets that don’t pay off until the 2030s — $18 billion of biotech changed hands inside 72 hours[^news-vrtx-crinetics-20260804][^news-lnth-curium-20260803]. Nobody was paying for the quarter. They were paying for the next five years. So today: two beats that got punished, one miss that turned into a proxy fight, and three companies on the same page of the memo making three incompatible bets on the same decade.
Ava: Telltales Weekend Update. I’m Ava Cabot, with Marcus Graham at the cashflow desk.
Theme — the quarter is a receipt
Ava: AMD delivered about as clean a print as semis produced this quarter, and the market took 7% out of the stock for it. Revenue $11.5 billion, up 52% year-over-year. Gross margin 54%. Net income $2.3 billion, EPS $1.30[^news-amd-q2-20260805]. Then the Q3 guide landed at $13.0 billion at the midpoint, above consensus[^news-amd-q3guide-20260805]. Beat, beat, and beat. Down 7%[^news-amd-stockdrop-20260805]. Marcus — what did they actually get punished for?
Marcus: Not the quarter. The price of admission. The memo had AMD at 88x trailing free cash flow going into this print, Q1 10-Q confirmed[^memo-amd-evfcf-20260807], on $8.7 billion of trailing free cash flow[^memo-amd-fcf-20260807]. We re-anchor when the Q2 10-Q files. At 88x you are not buying a beat, you are buying years of uninterrupted acceleration — and Jean Hu just told you the data center step-up is second-half weighted[^news-amd-datacenter-20260805]. Second-half weighted means the proof shows up after the multiple already has to hold. That’s the part that got sold.
Ava: And in the same week they went shopping. AMD agreed to buy Taalas, a Canadian startup, to add another category of AI silicon for the data center[^news-amd-taalas-20260806]. Marcus, is that a company that thinks it’s ahead?
Marcus: It’s a company hedging its own roadmap, which is the correct thing to do and an uncomfortable thing to watch. Going into this print the memo had AMD running $1.2 billion of capex trailing twelve[^memo-amd-capex-20260807] against under $1 billion of buybacks[^memo-amd-buyback-20260807], Q1 10-Q confirmed — and that was before Taalas. Lisa Su spent the week praising Elon Musk after SpaceX committed to Nvidia exclusively[^news-amd-musk-20260805]. Buying a second accelerator architecture says management does not believe one roadmap wins this market outright. That is honest, and it is the opposite of what a multiple in the high 80s is underwriting. The test is whether the Taalas silicon shows up in a customer deployment before that multiple has to be defended again.
Ava: Gracious in public, hedging in the checkbook. CVS beat the quarter, raised the year, then said one thing about 2027 and gave it all back. Adjusted EPS guidance up to $7.90–$8.10, from $7.30–$7.50[^news-cvs-q2guide-20260805]. $2 billion of costs already out the door, stores closed, leadership reshuffled[^news-cvs-costs-20260805]. And then a preliminary look at 2027 profit that disappointed, plus a warning about the pharmacy benefit business next year. Shares fell[^news-cvs-2027-20260805]. Marcus — twelve months of execution against one sentence about a year that hasn’t started.
Marcus: On this balance sheet, the sentence should win. The memo had CVS at 16x trailing free cash flow going in, Q1 10-Q confirmed[^memo-cvs-evfcf-20260807], carrying 7.5 turns of debt to free cash flow[^memo-cvs-debtfcf-20260807]. That leverage is what makes a 2027 comment expensive — a levered turnaround gets paid for the trajectory, not for the print. What would change my view is the pharmacy benefit line holding through next year’s renewal cycle. If it doesn’t, the deleveraging slides a year to the right, and the multiple is the thing doing the waiting.
Ava: And then Celsius, where a missed quarter turned into a job application. Q2 revenue $817.9 million against consensus of $870 million[^news-celh-revenue-20260806]. GAAP EPS down to $0.14 from $0.33 a year ago[^news-celh-eps-20260805]. The core Celsius brand shrank about 12%[^news-celh-brand-20260806]; Alani Nu retail sales grew 56%[^news-celh-alani-20260806]. So the growth is real. It’s just not the name on the can, and it’s not the name on the building. Adjusted EPS came in at $0.36, so the operating business is not broken[^news-celh-adjeps-20260805] — what’s broken is the story that Celsius, the brand, is the growth engine. Then Friday. Russ Savage, the man who founded Rockstar Energy, disclosed a 4.7% stake, more than 12 million shares, and said the board should replace CEO John Fieldly[^news-celh-savage-20260807]. With himself. Nobody buys 12 million shares of a company to relitigate last quarter. He’s buying the next five years of a portfolio he thinks is being run by the wrong person — and he built a competitor in this exact category before he bought a share of this one[^news-celh-savage-20260807].
Deep dive — page 15: Vertex, Lantheus, BioNTech
Ava: Page 15 of the Cash Flow Memo is pharma and biotech, and this week three names on that one page made three completely different bets on the same decade. Vertex is buying. Lantheus is being bought. BioNTech is shrinking.
Ava: Vertex beat, with Q2 revenue of $3.33 billion, up 12%[^news-vrtx-q2rev-20260803], raised full-year guidance to $13.1–$13.2 billion[^news-vrtx-guidance-20260804], and agreed to pay $10 billion in cash for Crinetics at $85 a share[^news-vrtx-crinetics-20260804]. Lantheus agreed to sell itself to Curium for up to $8 billion — $102.50 a share in cash at closing, plus up to $12 a share in contingent value rights, closing in the first half of 2027[^news-lnth-curium-20260803]. And BioNTech cut full-year revenue guidance from €2.5–€3.1 billion down to €1.6–€1.9 billion[^news-bntx-guidance-20260804], named Guido Oelkers to replace co-founder Ugur Sahin as CEO[^news-bntx-ceo-20260803], and said it will close manufacturing sites affecting up to 1,860 jobs while authorizing a $1 billion buyback[^news-bntx-layoffs-20260805]. Marcus — three answers to the same question. Which one is the market getting wrong?
Marcus: Lantheus, and the spread tells you where. The stock closed the week around $101[^memo-lnth-price-20260807] against $102.50 of cash at closing[^news-lnth-curium-20260803]. That’s a market saying the deal closes, and pricing the $12 of contingent value rights at approximately nothing. In radiopharmaceuticals the milestones are clinical, not commercial. A CVR with no bid is the market’s statement about what the buyer thinks it’s getting, and what the seller could never prove standing on its own.
Ava: Free option, no bid. And Vertex is standing on the other side of that trade.
Marcus: Vertex is paying cash for a pipeline it can’t sell for years, and it can afford to. The memo had Vertex at 30x trailing free cash flow going into the print, Q1 10-Q confirmed[^memo-vrtx-evfcf-20260807], on $3.7 billion of trailing free cash flow[^memo-vrtx-fcf-20260807]. $10 billion out the door against that clears without touching the debt line. We re-anchor when the Q2 10-Q files. What I’d watch is whether the raised guide survives the integration year, because a company that raises the year and writes the biggest check in its history in the same week is telling you the core franchise is funding the option, not the other way around.
Marcus: BioNTech is the one nobody wants to look at, and it’s the most honest of the three. Going into this print the memo had them at 7x trailing free cash flow[^memo-bntx-evfcf-20260807] at a 14% yield[^memo-bntx-fcfyield-20260807], Q1 10-Q confirmed, and those are euros, translated in the memo at today’s rate. That is a market that has stopped underwriting a future at all. Halving the guide, closing plants, and authorizing a buyback is management agreeing with that price. I’d weight it as a rational retreat rather than a value trap — but the two look identical until the oncology pipeline delivers data.
Ava: So what does page 15 actually say this week?
Marcus: That the discount rate on a biotech pipeline is being set by somebody other than the public market. Vertex at 30x trailing free cash flow and BioNTech at 7x sit on that same page[^memo-vrtx-evfcf-20260807][^memo-bntx-evfcf-20260807], applied to the same underlying activity — finding molecules that work. Curium is private capital, Vertex is a strategic, and both transacted above where the tape had the asset marked. When the price-setters on a page are a private buyer and a strategic buyer, the listed multiple stops being the opinion that matters. What would flip that is the Lantheus CVR trading with a real bid before the close.
Ava: Same page, same week, same disease franchises. One company spent $10 billion buying a decade. One took $102.50 a share to hand its decade to somebody else. One said out loud that it doesn’t have one to sell. Three managements priced their own optionality in public inside 72 hours. The earnings reactions were the small part.
Rapid fire
Ava: Rapid fire. ConocoPhillips posted its best profit since 2022 and used the same press cycle to change CEOs[^news-cop-profit-20260806]. Q2 earnings of $3.23 a share[^news-cop-q2eps-20260806]. Ryan Lance is out after 14 years into a transitional executive chair role; CFO Andy O’Brien becomes president and CEO September 1, with Konnie Haynes-Welsh moving up to CFO[^news-cop-succession-20260806]. Going into the print, the memo had Conoco at 9x trailing free cash flow[^memo-cop-evfcf-20260807] at a 10.8% yield[^memo-cop-fcfyield-20260807], on $18.5 billion of trailing free cash flow[^memo-cop-fcf-20260807]. That trailing twelve carried $4.0 billion of dividends and $4.5 billion of buybacks[^memo-cop-dividend-20260807][^memo-cop-buyback-20260807]. Handing a franchise returning that much capital to the finance seat at the top of the cycle is a choice. The thing to watch is whether the return pace survives the handoff, because a new CEO who came up through the CFO’s chair has every incentive to build a war chest in his first year.
Ava: Harrow bought a product four days before it has to explain itself. Definitive agreement for the global rights to Tyrvaya from Viatris — $30 million up front, up to $70 million more in milestones tied to net sales[^news-hrow-tyrvaya-20260806]. Tyrvaya is the only FDA-approved nasal spray for dry eye disease[^news-hrow-tyrvaya-fda-20260806]. On page 20 of the memo, Harrow sits at 46x trailing free cash flow[^memo-hrow-evfcf-20260807] with 8 turns of debt to free cash flow[^memo-hrow-debtfcf-20260807], Q1 10-Q confirmed. And Harrow reports Monday, consensus at a $0.23 loss on $70.4 million of revenue[^earn-hrow]. A levered specialty pharma company buying a commercial asset the week of its own print is either conviction or timing. Monday says which.
Ava: Also on page 20. Uber grew gross bookings 22%[^news-uber-bookings-20260804] and non-GAAP operating income 40%[^news-uber-opinc-20260804], then guided Q3 light and dropped 5%[^news-uber-guidance-20260805] — the same week it committed more than $10 billion to a robotaxi aggregator strategy[^news-uber-robotaxi-20260806]. And Airbnb beat and raised full-year revenue guidance to at least mid-teens growth[^news-abnb-guidance-20260807], with the stock up 15%[^news-abnb-surge-20260807] on a World Cup travel surge[^news-abnb-worldcup-20260807]. Brian Chesky says the company will spend a lot more on AI this year because inference came in cheaper than he budgeted for[^news-abnb-ceoai-20260807]. Which is a CEO announcing his own forecast was wrong, in the happiest available way.
Ava: Two more. Palantir grew US commercial revenue 149% to $764 million[^news-pltr-commercial-20260804], total revenue 93%[^news-pltr-total-20260804], raised the year to 82% growth[^news-pltr-fyguide-20260804], and put up 29% in a single session[^news-pltr-surge-20260804]. The memo had it at 102x trailing free cash flow before any of that, Q1 10-Q confirmed[^memo-pltr-evfcf-20260807]. 102x. Alex Karp’s line on the call was that his customers have, quote, declined to become vassal states of the language labs[^news-pltr-karp-20260804]. Nobody has ever sold sovereignty harder, and at 102x, nobody has ever needed to. And Disney beat on fiscal Q3[^news-dis-q3-20260805], sold its 50% stake in A+E Global Media to Hearst for $1.2 billion[^news-dis-ae-20260805], and signed a global short-form content deal with TikTok[^news-dis-tiktok-20260806] — three storylines, one week. Disney is selling the cable asset and renting the attention.
Ava: Forward calendar. Harrow Monday[^earn-hrow]. Venture Global Tuesday[^earn-vg]. Then the consumer block the week after — Home Depot Tuesday[^earn-hd], Lowe’s and Target Wednesday[^earn-low][^earn-tgt], Walmart and Deere Thursday[^earn-wmt][^earn-de]. Five names, three days, and the whole picture on household spending.
Close
Ava: That’s the show. A good quarter bought nothing this week. Wall Street’s consensus on earnings season: a beat gets bought. AMD beat on revenue, profit, and the guide and lost 7%. CVS beat and raised and gave it back on one sentence about 2027. Consensus is still grading last quarter’s tape.
Ava: What actually got paid for this week was the 2030s — $10 billion for Crinetics, up to $8 billion for Lantheus, $100 million for a single nasal spray. The prints were the receipts.
Ava: On Wednesday’s episode 2632, Hunt, Jason, and Mike took Harrow through the AI-in-healthcare segment and landed on it as a commercialization business, one where AI isn’t the deciding factor[^ep-e2632]. Four days later Harrow went out and bought something to commercialize. Hunt, Jason, and Mike are back Wednesday on episode 2633.
Ava: Download the memo at telltales.us. Twenty pages, every week. And send us feedback through the Substack. Every note gets seen.
Ava: The show is produced entirely with AI tools, and both voices you’re hearing are AI-generated.
Closing disclaimer
Ava: The following conversation is intended for informational purposes only. You should always do your own work to determine if an investment is suitable for you. The views expressed on this podcast are the host alone and do not constitute an offer to sell or a recommendation to purchase, or a solicitation of an offer to buy any security, nor a recommendation for any investment product or service. While certain information contained herein has been obtained from sources believed to be reliable, neither the host nor any of their employers or their affiliates have independently verified this information, and its accuracy and completeness cannot be guaranteed. Accordingly, no representation or warranty, express or implied, is made as to, and no reliance should be placed on, the fairness, accuracy, timeliness, or completeness of this information. The host and all employers and their affiliated persons assume no liability for this information and no obligation to update the information or analysis contained herein in the future, and may or may not hold positions in the securities mentioned.
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* Palantir Technologies. (2026, August 4). Q2 2026 press release [Exhibit 99.1]. U.S. Securities and Exchange Commission EDGAR. https://www.sec.gov/Archives/edgar/data/1321655/000132165526000039/a2026q2ex991pressrelease.htm
* Reuters. (2026, August 3). Palantir lifts annual revenue forecast on steady demand. Reuters. https://reuters.com/technology/palantir-raises-annual-revenue-forecast-strong-demand-us-government-commercial-2026-08-03
* Reuters. (2026, August 5). BioNTech SE company page: manufacturing site closures and $1.0 billion buyback authorization. Reuters. https://www.reuters.com/company/biontech-se/
* StockAnalysis. (2026, August 6). Celsius Holdings (CELH) stock price & overview. StockAnalysis. https://stockanalysis.com/stocks/celh/
* StockTitan. (2026, August 4). Crinetics (Nasdaq: CRNX) agrees to $85 cash-per-share sale to Vertex [8-K material event]. StockTitan. https://www.stocktitan.net/sec-filings/CRNX/8-k-crinetics-pharmaceuticals-inc-reports-material-event-3bad8e8db9de.html
* The Walt Disney Company. (2026, August 6). The Walt Disney Company and TikTok announce a first-of-its-kind global short-form content-sharing deal [Press release]. https://thewaltdisneycompany.com/news/tiktok-content-sharing-deal/
* TradingKey. (2026, August 5). AMD beat on revenue, profit, and guidance — So why did the stock drop 7%? TradingKey. https://www.tradingkey.com/analysis/stocks/us-stocks/262074451-amd-q2-2026-earnings-double-beat-stock-falls-tradingkey
* Uber Technologies. (2026, August 4). Uber announces results for second quarter 2026 [Press release]. https://investor.uber.com/news-events/news/press-release-details/2026/Uber-Announces-Results-for-Second-Quarter-2026/default.aspx
* Vertex Pharmaceuticals. (2026, August 3). Vertex reports second quarter 2026 financial results [Press release]. https://news.vrtx.com/news-releases/news-release-details/vertex-reports-second-quarter-2026-financial-results
* Yahoo Finance. (2026, August 4). Vertex Pharmaceuticals Inc (VRTX) (Q2 2026) earnings call highlights: Revenue surges 12%. Yahoo Finance. https://finance.yahoo.com/healthcare/articles/vertex-pharmaceuticals-inc-vrtx-q2-050826035.html
* Yahoo Finance. (2026, August 6). Celsius Q2 earnings call highlights. Yahoo Finance. https://finance.yahoo.com/markets/stocks/articles/celsius-q2-earnings-call-highlights-130400635.html
* Yahoo Finance UK. (2026, August 6). Celsius Holdings Inc (CELH) (Q2 2026) earnings call highlights: Portfolio growth drives 11%. Yahoo Finance UK. https://uk.finance.yahoo.com/news/celsius-holdings-inc-celh-q2-190423226.html
Note: reference 2 (AP News) is retained from the dryrun source pool and is not cited in the shipped script. All other entries map to at least one footnote in the canonical.
Internal data
Internal data is provided on a best efforts basis.
Earnings slate
Forward earnings dates are sourced from the W2632 earnings slate, pulled 2026-08-07. See 04. Publishing/shows/weekend-update/W2632/dryrun/earnings_slate.md.
* DE - Deere & Company, 2026-08-20 (Thursday), consensus EPS 4.71, consensus revenue $10.8B
* HD - Home Depot, 2026-08-18 (Tuesday), consensus EPS 4.73, consensus revenue $47.3B
* HROW - Harrow Inc, 2026-08-10 (Monday), consensus EPS -0.23, consensus revenue $70.4M
* LOW - Lowe’s, 2026-08-19 (Wednesday), consensus EPS 4.25, consensus revenue $26.2B
* TGT - Target, 2026-08-19 (Wednesday), consensus EPS 2.30, consensus revenue $26.1B
* VG - Venture Global, 2026-08-11 (Tuesday), consensus EPS 0.48, consensus revenue $4.7B
* WMT - Walmart, 2026-08-20 (Thursday), consensus EPS 0.74, consensus revenue $186.8B
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