LessWrong (30+ Karma)

“That’s Not How Epigenetic Modifications Work” by johnswentworth


Listen Later

Ask an epigenetics researcher what they study, and the standard story you'll hear goes something like this...

"Sometimes a little methyl group (i.e. -CH3) gets stuck on the side of a strand of DNA. Turns out these guys are pretty important! They're copied over when cells replicate, so they stick around long-term, and they can activate or repress (usually repress) nearby genes on the DNA strand. In particular, different types of cells all have the same DNA code, but something has to be different in order for the cells to "remember" what type they are and behave differently. And sure enough, those methyl modifications differ across cell types! They're like an extra information storage mechanism, on top of the DNA, which can encode things like cell type and make different cell types behave differently, among other forms of memory."

That story is wrong. Many of the details are correct [...]

---

First published:

May 24th, 2025

Source:

https://www.lesswrong.com/posts/wzkK9kxaZmmXGi6ZP/that-s-not-how-epigenetic-modifications-work

---

Narrated by TYPE III AUDIO.

...more
View all episodesView all episodes
Download on the App Store

LessWrong (30+ Karma)By LessWrong


More shows like LessWrong (30+ Karma)

View all
Making Sense with Sam Harris by Sam Harris

Making Sense with Sam Harris

26,365 Listeners

Conversations with Tyler by Mercatus Center at George Mason University

Conversations with Tyler

2,436 Listeners

The Peter Attia Drive by Peter Attia, MD

The Peter Attia Drive

8,971 Listeners

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas by Sean Carroll | Wondery

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

4,148 Listeners

ManifoldOne by Steve Hsu

ManifoldOne

92 Listeners

Your Undivided Attention by The Center for Humane Technology, Tristan Harris, Daniel Barcay and Aza Raskin

Your Undivided Attention

1,595 Listeners

All-In with Chamath, Jason, Sacks & Friedberg by All-In Podcast, LLC

All-In with Chamath, Jason, Sacks & Friedberg

9,913 Listeners

Machine Learning Street Talk (MLST) by Machine Learning Street Talk (MLST)

Machine Learning Street Talk (MLST)

90 Listeners

Dwarkesh Podcast by Dwarkesh Patel

Dwarkesh Podcast

72 Listeners

Hard Fork by The New York Times

Hard Fork

5,475 Listeners

The Ezra Klein Show by New York Times Opinion

The Ezra Klein Show

16,076 Listeners

Moonshots with Peter Diamandis by PHD Ventures

Moonshots with Peter Diamandis

536 Listeners

No Priors: Artificial Intelligence | Technology | Startups by Conviction

No Priors: Artificial Intelligence | Technology | Startups

131 Listeners

Latent Space: The AI Engineer Podcast by swyx + Alessio

Latent Space: The AI Engineer Podcast

95 Listeners

BG2Pod with Brad Gerstner and Bill Gurley by BG2Pod

BG2Pod with Brad Gerstner and Bill Gurley

515 Listeners