In this Alzheimer's Solution Revolution episode #4, I’ll give an overview of episode #3, and I’ll provide several key insights about a protein that is associated with the pathology of Alzheimer’s disease—beta-amyloid protein, which forms the proverbial amyloid plaque that is often cited as a principal lesion of the disease process.

Additionally, in this Think Ahead podcast, I pick up where we left off on the last episode (#3) with regard to the genesis of Alzheimer’s, disease in the brain, and the role of beta-amyloid protein aggregates in the progression of Alzheimer’s disease in aging. I illustrate how the disease process can progress from the preclinical stage (asymptomatic) to a mild cognitive impairment stage, and eventually a diagnosis of a dementia associated with Alzheimer's disease,

Please listen in to continue learning how amyloid precursor protein is processed to produce beta-amyloid protein particles and aggregates, which underlies the earliest stage (preclinical) of the Alzheimer’s disease continuum that can span decades before an eventual diagnosis of dementia.

Lastly, we touch on the role of the APOE gene and the ApoE4 variant—the most validated late-onset Alzheimer’s disease genetic risk variant— with regard to beta-amyloid accumulation in the brain, and how research has significantly progressed over the years to illuminate how we can leverage these new findings to reduce the risk for late-onset Alzheimer’s disease.

We end with what to anticipate in an additional podcast coming soon in the Think Ahead series—the role of tau protein and neurofibrillary tangles in Alzheimer’s disease.

Ralph Sanchez, MTCM, CNS, D.Hom

www.TheAlzheimersSolution.com

https://www.facebook.com/TheAlzheimersSolution

https://www.linkedin.com/in/ralph-sanchez

https://www.instagram.com/alzheimers_solution

In this 3rd episode of The Alzheimer’s Solutions Revolution Podcast, I, Ralph Sanchez, talk with my good friend and co-host Susan Brender, as we begin this special podcast series designated as the Think Ahead podcast series.

In the Think Ahead series, which will be published here over the coming weeks, I'll provide an extensive overview on the numerous risk factors associated with late-onset Alzheimer’s disease (LOAD), and I expand on the research that sheds light on how you can modify and reduce your risk for LOAD and dementia as you age.

In the first Think Ahead episode, I lay down the foundation for understanding the genesis and difference between early onset Alzheimer’s disease (EOAD) and LOAD, and the science-based findings that illuminates the association between many risk factors—including genes and genetic variants, that are linked to Alzheimer’s disease.

Additionally, I'll begin the overview on the hallmark protein-based lesions (amyloid plaques and neurofibrillary tangles) that are associated with Alzheimer’s is discussed. More on that topic to come in subsequent Think Ahead podcasts here at The Alzheimer's Solution Revolution podcast channel.

Please, listen and empower yourself with a basic understanding of the early stages of EOAD and LOAD that includes the genetic determinants and genetic risk factors for each, and the stages of the disease process that leads to cognitive impairment and dementia in aging.

Should you supplement with a basic MVM to sustain a healthy brain in aging? Has any physician or practitioner emphasized just how important a MVM supplement might be for your brain and heart as you get older?

Well, as promised on my welcome episode last week, I'll be expanding on a study and recent research with regard to the supplementation with vitamins, minerals and certain nutrients found in foods, and it's role in the heart-brain axis in this episode of The Alzheimer's Solution Revolution Podcast.

The study that I will be referring to today looked at the potential benefits of a cocoa extract and a multivitamin-mineral supplement (MVM) together, and separately vs. combinations of the two and a vs placebo on Global Cognitive Function which was measured by a composite global functioning score—cognitive assessments that are commonly used in trials and clinical settings to assess cognitive function.

The outcome?

"Taking a daily multivitamin (MVM) for 3 years is associated with a 60% slowing of cognitive aging, with the effects especially pronounced in patients with cardiovascular (CVD) disease,."

The MVM benefit on cognition peaked at 2 years and remained stable over time and included significant improvement measures of memory composite score and executive function.

Surprisingly o beneficial effect was linked to the intake of cocoa flavanols—a plant chemical which part of the larger polyphenol phytochemical family— over the 3 year study period.

However, there is much more to the story regarding the potential role of flavanols and many other polyphenols and I cover that in detail in this episode that includes how vitamins, minerals and polyphenols benefit and optimize cognitive function and protect it against the onset of dementia in aging.

Listen in as I dive into all the juicy details!

Ralph Sanchez, MTCM, CNS, D.Hom

www.TheAlzheimersSolution.com

https://www.facebook.com/TheAlzheimersSolution

https://www.linkedin.com/in/ralph-sanchez

https://www.instagram.com/alzheimers_solution

Welcome!

Indeed, this is the inaugural episode of the The Alzheimer's Solution Revolution Podcast!

This is your host. Ralph Sanchez, and I am grateful that you are reading and/or listening in to what this podcast will bringing to you on a weekly basis.

The purpose of this welcome edition is to share a little about me and my experience and background in health care and medicine that emphasized a progressive paradigm and model of healthcare termed functional medicine. 

Essentially, the overall scope of this podcast will to bring you cutting edge information on how you can enhance your wellness, your brain health, and your wellness longevity—your healthspan.

Now, the inspiration as well as for the inclusion of word "Revolution" in my podcast title stems from the fact that over the the past 20 plus years, proposed solutions to the Alzheimer’s pandemic have gone from none to many studies and experts in the field now advocating prevention measures for dementia and late-onset Alzheimer's disease that must begin earlier in life.

I’ll be expanding on all of this over the next few weeks in order to lay a foundation for this podcast and the type of information I will be sharing and talking about, and then I’ll have guests that on the show that bring a unique set of skills, resources, and experience for you to benefit from.

So please, look for me wherever you enjoy looking for and listening to your favorite podcasts, and you can learn more about me and my mission in my book, and my brain health program—BrainDefend, at my website—www.TheAlzheimersSolution.com or at www.BrainDefend.com

Lastly a review at Apple or Google podcasts or wherever you go to search for podcast would be very much appreciated and if you subscribe to this podcast, you’ll be sure to be automatically alerted about the newest edition of the podcast when it's released.

Thank you for stopping by and listening and I can’t wait to be back next week to continue this Alzheimer's Solution Revolution podcast journey with you!

God bless...Ralph Sanchez, MTCM, CNS, D.Hom

www.TheAlzheimersSolution.com

https://www.facebook.com/TheAlzheimersSolution

https://www.linkedin.com/in/ralph-sanchez

https://www.instagram.com/alzheimers_solution